UniProt P41180
Extracellular calcium-sensing receptor (P41180)
Extracellular calcium-sensing receptor (UniProt P41180): 35 experimental structures and 1 predicted model on GenesisL1, 24 ligands bound, 261 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- P41180
- Protein
- Extracellular calcium-sensing receptor
- Experimental structures
- 35
- Predicted models
- 1
- Ligands
- 24
- Pockets
- 261 · 16 records with a druggable one
Structures
36 records of P41180 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5FBH | Crystal structure of the extracellular domain of human calcium sensing receptor with bound Gd3+ | x-ray diffraction | B, A | GD3, MG, BCT, CL, NAG | — |
| 5FBH | Crystal structure of the extracellular domain of human calcium sensing receptor with bound GD3+ | x-ray diffraction | B, A | — | — |
| 5FBK | Crystal structure of the extracellular domain of human calcium sensing receptor | x-ray diffraction | A, B | NAG, CL, BCT, MG | — |
| 5FBK | Crystal structure of the extracellular domain of human calcium sensing receptor | x-ray diffraction | A, B | — | — |
| 5K5S | Crystal structure of the active form of human calcium-sensing receptor extracellular domain | x-ray diffraction | A, B | TRP, PO4, CA, NAG | 12 (best 0.89) |
| 5K5S | Crystal structure of the active form of human calcium-sensing receptor extracellular domain | x-ray diffraction | A, B | PO4, CA, NAG | — |
| 5K5T | Crystal structure of the inactive form of human calcium-sensing receptor extracellular domain | x-ray diffraction | A | CA, SO4, NAG | 5 (best 0.64) |
| 5K5T | Crystal structure of the inactive form of human calcium-sensing receptor extracellular domain | x-ray diffraction | A | CA, SO4, NAG | — |
| 7DTT | Human calcium-sensing receptor bound with calcium ions | electron microscopy | A, B | NAG, CA | — |
| 7DTU | Human calcium-sensing receptor bound with L-TRP | electron microscopy | A, B | NAG | — |
| 7DTV | Human calcium-sensing receptor bound with L-TRP and calcium ions | electron microscopy | A, B | NAG, CA | — |
| 7DTW | Human calcium-sensing receptor in the inactive close-close conformation | electron microscopy | A, B | NAG | — |
| 7E6T | Structural insights into the activation of human calcium-sensing receptor | electron microscopy | B, A | PO4, CA, NAG | — |
| 7E6U | the complex of inactive CaSR and NB2D11 | electron microscopy | A, C | — | 20 (best 0.86) |
| 7E6U | The complex of inactive casr and NB2D11 | electron microscopy | A, C | — | — |
| 7M3E | Asymmetric Activation of the Calcium Sensing Receptor Homodimer | electron microscopy | A, B | NAG, YP1, TRP, CA, PO4 | 20 (best 0.89) |
| 7M3E | Asymmetric activation of the calcium sensing receptor homodimer | electron microscopy | A, B | NAG, YP1, CA, PO4 | — |
| 7M3F | Asymmetric activation of the calcium sensing receptor homodimer | electron microscopy | A, B | NAG, YP4, CA, PO4 | — |
| 7M3G | Asymmetric Activation of the Calcium Sensing Receptor Homodimer | electron microscopy | A, B | NAG, H43, TRP, CA, PO4 | 20 (best 0.89) |
| 7M3G | Asymmetric activation of the calcium sensing receptor homodimer | electron microscopy | A, B | ACE, NH2, NAG, H43, CA, PO4 | — |
| 7M3J | Asymmetric Activation of the Calcium Sensing Receptor Homodimer | electron microscopy | A, B | NAG, YP1, PO4 | 20 (best 0.84) |
| 7M3J | Asymmetric activation of the calcium sensing receptor homodimer | electron microscopy | A, B | NAG, YP1, PO4 | — |
| 7SIL | Structure of positive allosteric modulator-bound active human calcium- sensing receptor | electron microscopy | — | — | |
| 7SIM | Structure of positive allosteric modulator-free active human calcium- sensing receptor | electron microscopy | — | — | |
| 7SIN | Structure of negative allosteric modulator-bound inactive human calcium-sensing receptor | electron microscopy | — | — | |
| 8SZF | Cryo-EM structure of cinacalcet-bound active-state human calcium-sensing receptor CaSR in lipid… | electron microscopy | A, B | NAG, TRP, CA, PO4, YP4, SPM | 17 (best 0.89) |
| 8SZG | Cryo-EM structure of cinacalcet-bound human calcium-sensing receptor CaSR-Gq complex in lipid… | electron microscopy | A, B | NAG, YP4, PCW, SPM, CA, TRP | 15 (best 0.89) |
| 8SZH | Cryo-EM structure of cinacalcet-bound human calcium-sensing receptor CaSR-Gi complex in lipid… | electron microscopy | A, B | NAG, YP4, PCW, CA, TRP, PO4 | 17 (best 0.86) |
| 8WPU | Human calcium-sensing receptor(CaSR) bound to cinacalcet in complex with Gq protein | electron microscopy | B, A | NAG, YP4, TRP, CA, PO4, CLR | 15 (best 0.86) |
| 9ASB | Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in… | electron microscopy | Q, R | NAG, TCR, PO4, CA, 9IG, Y01 | 17 (best 0.89) |
| 9AVG | Structure of human calcium-sensing receptor in complex with chimeric Gs (miniGis) protein in… | electron microscopy | Q, R | NAG, TCR, PO4, CA, 9IG, Y01 | 17 (best 0.89) |
| 9AVL | Structure of human calcium-sensing receptor in complex with Gi3 protein in nanodiscs | electron microscopy | Q, R | NAG, TCR, PO4, CA, 9IG, Y01 | 17 (best 0.86) |
| 9AYF | Structure of human calcium-sensing receptor in complex with Gi1 (miniGi1) protein in detergent | electron microscopy | Q, R | NAG, TCR, PO4, CA, 9IG, AV0 | 16 (best 0.89) |
| 9C1P | Structure of Calcium-Sensing Receptor in complex with positive allosteric modulator '6218 | electron microscopy | A, B | NAG, CA, TRP, PO4, A1ATP | 16 (best 0.87) |
| 9C2F | Structure of Calcium-Sensing Receptor in complex with positive allosteric modulator '54149 | electron microscopy | A, B | NAG, CA, TRP, PO4, A1ATX | 17 (best 0.86) |
| P41180 | AlphaFold monomer V2.0 prediction for extracellular calcium-sensing receptor (P41180) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 28 records
- CA · Calcium ion · in 22 records
- PO4 · Phosphate ion · in 20 records
- TRP · Tryptophan · in 9 records
- YP4 · N-[(1R)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine · in 5 records
- 9IG · 3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl) ethyl]propan-1-amine · in 4 records
- TCR · Cyclomethyltryptophan · in 4 records
- YP1 · 2-chloro-6-[(2R)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino}propoxy]benzonitrile · in 4 records
- A1AF7 · (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate · in 3 records
- CLR · Cholesterol · in 3 records
- SPM · Spermine · in 3 records
- Y01 · Cholesterol hemisuccinate · in 3 records
- BCT · Bicarbonate ion · in 2 records
- CL · Chloride ion · in 2 records
- H43 · 2-[4-[(3S)-3-[[(1R)-1-naphthalen-1-ylethyl]amino]pyrrolidin-1-yl]phenyl]ethanoic acid · in 2 records
- MG · Magnesium ion · in 2 records
- PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · in 2 records
- SO4 · Sulfate ion · in 2 records
- A1ATP · (5R)-N-[2-(1,2-benzothiazol-3-yl)ethyl]-1-methyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-amine · in 1 record
- A1ATX · (1R)-1-(2H-1,3-benzodioxol-4-yl)-N-[2-(1,2-benzothiazol-3-yl)ethyl]ethan-1-amine · in 1 record
- ACE · Acetyl group · in 1 record
- AV0 · 2-decyl-2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}dodecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside · in 1 record
- GD3 · Gadolinium ion · in 1 record
- NH2 · Amino group · in 1 record
Experiment against prediction
- 5FBK chain B against the predicted model P41180: TM-score 0.98, RMSD 1.11 Å
- 5FBK chain B against the predicted model P41180: TM-score 0.98, RMSD 1.11 Å
- 5FBH chain A against the predicted model P41180: TM-score 0.98, RMSD 1.14 Å
- 5FBH chain A against the predicted model P41180: TM-score 0.98, RMSD 1.14 Å
- 5FBH chain B against the predicted model P41180: TM-score 0.98, RMSD 1.25 Å
- 5FBH chain B against the predicted model P41180: TM-score 0.98, RMSD 1.25 Å
- 5K5S chain A against the predicted model P41180: TM-score 0.97, RMSD 1.36 Å
- 5K5S chain B against the predicted model P41180: TM-score 0.97, RMSD 1.49 Å
- 5K5S chain A against the predicted model P41180: TM-score 0.97, RMSD 1.36 Å
- 5K5S chain B against the predicted model P41180: TM-score 0.97, RMSD 1.49 Å
Elsewhere
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