MolNFT v1 · #177079 · protein
Structural insights into the activation of human calcium-sensing receptor
7E6T · Extracellular calcium-sensing receptor: “Structural insights into the activation of human calcium-sensing receptor”. Electron microscopy, 4 ligands (TCR, NAG, CA), 20 pockets (best druggability 0.88). MolNFT v1 #177079 on GenesisL1…
- PDB
- 7E6T
- Type
- protein
- Length
- 1,589 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Extracellular calcium-sensing receptor
- UniProt
- P41180
- Ligands
- TCR, NAG, CA, PO4
- Pockets
- 20 · best druggability 0.88
Structure
electron microscopy · 2 distinct chains · 38% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Extracellular calcium-sensing receptor | protein | 793 | 39% helix, 15% strand | P41180 |
| A | Extracellular calcium-sensing receptor | protein | 796 | 38% helix, 15% strand | P41180 |
Ligands and binding sites
- TCR · Cyclomethyltryptophan · ligand · 2 copies · chains B, A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains B, A
- CA · Calcium ion · metal · 6 copies · chains B, A
- PO4 · Phosphate ion · ion · 2 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1070 | 0.88 | 0.90 | 151 | TCR, PO4, CA |
| 2 | 289 | 0.81 | 0.92 | 34 | empty |
| 3 | 997 | 0.79 | 0.81 | 97 | NAG |
| 4 | 363 | 0.78 | 0.87 | 62 | empty |
| 5 | 107 | 0.71 | 0.92 | 26 | empty |
Interfaces
1 interface between chains.
- B–A · 3097 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 11 disulfide, 4 glycan (disulfide, N-glycosylation).
Compared structures
- 7E6T · Structural insights into the activation of human calcium-sensing receptor · the same entry in another collection · chain B against B, TM-score 1.00
- P41180 · AlphaFold monomer V2.0 prediction for extracellular calcium-sensing receptor (P41180) · a predicted model of the same protein · chain A against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P41180
- Elsewhere: RCSB PDB 7E6T · PDBe 7E6T · UniProt P41180
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.