MolNFT v1 · #176662 · protein
Human calcium-sensing receptor in the inactive close-close conformation
7DTW · Extracellular calcium-sensing receptor: “Human calcium-sensing receptor in the inactive close-close conformation”. Electron microscopy, 1 ligand (NAG), 18 pockets (best druggability 0.82). MolNFT v1 #176662 on GenesisL1: 3D…
- PDB
- 7DTW
- Type
- protein
- Length
- 1,556 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Extracellular calcium-sensing receptor
- UniProt
- P41180
- Ligands
- NAG
- Pockets
- 18 · best druggability 0.82
Structure
electron microscopy · 1 distinct chain · 40% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Extracellular calcium-sensing receptor | protein | 778 | 40% helix, 10% strand | P41180 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 14 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
18 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 223 | 0.82 | 0.95 | 39 | empty |
| 2 | 232 | 0.82 | 0.94 | 44 | empty |
| 3 | 290 | 0.82 | 0.92 | 59 | empty |
| 4 | 304 | 0.81 | 0.92 | 62 | empty |
| 5 | 1065 | 0.81 | 0.83 | 101 | empty |
Interfaces
1 interface between chains.
- A–B · 1229 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 disulfide, 10 glycan (disulfide, N-glycosylation).
Compared structures
- 7DTW · Human Calcium-Sensing Receptor in the inactive close-close conformation · the same entry in another collection · chain A against A, TM-score 1.00
- P41180 · AlphaFold monomer V2.0 prediction for extracellular calcium-sensing receptor (P41180) · a predicted model of the same protein · chain B against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P41180
- Elsewhere: RCSB PDB 7DTW · PDBe 7DTW · UniProt P41180
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.