UniProt P32523
Pre-mRNA-processing factor 19 (P32523)
Pre-mRNA-processing factor 19 (UniProt P32523), EC 2.3.2.27, 6.3.2.-: 31 experimental structures and 1 predicted model on GenesisL1, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P32523
- Protein
- Pre-mRNA-processing factor 19
- EC
- 2.3.2.27, 6.3.2.-
- Experimental structures
- 31
- Predicted models
- 1
- Pockets
- 17 · 7 records with a druggable one
Structures
32 records of P32523 in the MolNFT archive: 31 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1N87 | Solution structure of the U-box of Prp19 | solution nmr | A | — | — |
| 1N87 | Solution structure of the U-box of PRP19 | solution nmr | A | — | — |
| 2BAY | Crystal structure of the Prp19 U-box dimer | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2BAY | Crystal structure of the PRP19 U-box dimer | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3LRV | The Prp19 WD40 Domain Contains a Conserved Protein Interaction Region Essential for its Function. | x-ray diffraction | A | — | — |
| 3LRV | The PRP19 WD40 domain contains a conserved protein interaction region essential for its function. | x-ray diffraction | A | — | — |
| 4ZB4 | Spliceosome component | x-ray diffraction | A, B | — | 9 (best 0.77) |
| 4ZB4 | Spliceosome component | x-ray diffraction | A, B | — | — |
| 5GM6 | Cryo-EM structure of the activated spliceosome (Bact complex) at 3.5 angstrom resolution | electron microscopy | o, p, q, r | — | 1 (best 0.82) |
| 5GMK | Cryo-EM structure of the catalytic step I spliceosome (C complex) at 3.4 ångström resolution | electron microscopy | o, p, q, r | — | — |
| 5LJ5 | Overall structure of the yeast spliceosome immediately after branching. | electron microscopy | t, u, v, w | — | — |
| 5M8C | Spliceosome component | x-ray diffraction | A, B | — | — |
| 5M8C | Spliceosome component | x-ray diffraction | A, B | — | — |
| 5MQ0 | Structure of a spliceosome remodeled for exon ligation | electron microscopy | t, u, v, w | — | — |
| 5MQ0 | Structure of a spliceosome remodeled for exon ligation | electron microscopy | t, u, v, w | — | — |
| 5WSG | Cryo-EM structure of the Catalytic Step II spliceosome (C* complex) at 4.0 angstrom resolution | electron microscopy | o, p, q, r | — | — |
| 5WSG | Cryo-EM structure of the catalytic step II spliceosome (C* complex) at 4.0 ångström resolution | electron microscopy | o, p, q, r | — | — |
| 5Y88 | Cryo-EM structure of the intron-lariat spliceosome ready for disassembly from S.CEREVISIAE at 3.5… | electron microscopy | q, r, s, t | — | — |
| 5YLZ | Cryo-EM Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae at 3.6 angstrom | electron microscopy | q, r, s, t | — | — |
| 5YLZ | Cryo-EM structure of the post-catalytic spliceosome from saccharomyces cerevisiae at 3.6 ångström | electron microscopy | q, r, s, t | — | — |
| 6BK8 | S. cerevisiae spliceosomal post-catalytic P complex | electron microscopy | u, v, w, x | — | — |
| 6EXN | Post-catalytic P complex spliceosome with 3' splice site docked | electron microscopy | t, u, v, w | — | — |
| 6EXN | Post-catalytic P complex spliceosome with 3' splice site docked | electron microscopy | t, u, v, w | — | — |
| 6J6G | Cryo-EM structure of the yeast B*-a2 complex at an average resolution of 3.2 angstrom | electron microscopy | r, p, q, o | — | 1 (best 0.83) |
| 6J6G | Cryo-EM structure of the yeast B*-A2 complex at an average resolution of 3.2 ångström | electron microscopy | r, p, q, o | — | — |
| 6J6H | Cryo-EM structure of the yeast B*-a1 complex at an average resolution of 3.6 angstrom | electron microscopy | r, p, q, o | — | 1 (best 0.83) |
| 6J6H | Cryo-EM structure of the yeast B*-A1 complex at an average resolution of 3.6 ångström | electron microscopy | r, p, q, o | — | — |
| 6J6N | Cryo-EM structure of the yeast B*-b1 complex at an average resolution of 3.86 angstrom | electron microscopy | r, p, q, o | — | 1 (best 0.83) |
| 6J6N | Cryo-EM structure of the yeast B*-B1 complex at an average resolution of 3.86 ångström | electron microscopy | r, p, q, o | — | — |
| 6J6Q | Cryo-EM structure of the yeast B*-b2 complex at an average resolution of 3.7 angstrom | electron microscopy | r, p, q, o | — | 1 (best 0.83) |
| 6J6Q | Cryo-EM structure of the yeast B*-B2 complex at an average resolution of 3.7 ångström | electron microscopy | r, p, q, o | — | — |
| P32523 | AlphaFold monomer V2.0 prediction for pre-mRNA-processing factor 19 (P32523) | predicted | A | — | 3 (best 0.74) |
Experiment against prediction
- 5M8C chain B against the predicted model P32523: TM-score 0.99, RMSD 0.60 Å
- 5M8C chain B against the predicted model P32523: TM-score 0.99, RMSD 0.60 Å
- 4ZB4 chain B against the predicted model P32523: TM-score 0.99, RMSD 0.61 Å
- 4ZB4 chain B against the predicted model P32523: TM-score 0.99, RMSD 0.61 Å
- 4ZB4 chain A against the predicted model P32523: TM-score 0.99, RMSD 0.78 Å
- 4ZB4 chain A against the predicted model P32523: TM-score 0.99, RMSD 0.78 Å
- 5M8C chain A against the predicted model P32523: TM-score 0.99, RMSD 0.79 Å
- 5M8C chain A against the predicted model P32523: TM-score 0.99, RMSD 0.79 Å
- 3LRV chain A against the predicted model P32523: TM-score 0.98, RMSD 1.03 Å
- 3LRV chain A against the predicted model P32523: TM-score 0.98, RMSD 1.03 Å
Elsewhere
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