MolNFT v1 · #126622 · protein

Spliceosome component

5M8C · Pre-mRNA-processing factor 19: “Spliceosome component”. X-ray diffraction, 7 pockets (best druggability 0.76). MolNFT v1 #126622 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5M8C
Type: protein
Length: 694 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pre-mRNA-processing factor 19
EC: 2.3.2.27
UniProt: P32523
Pockets: 7 · best druggability 0.76

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pre-mRNA-processing factor 19 (EC 2.3.2.27)	protein	353	5% helix, 47% strand	P32523
B	Pre-mRNA-processing factor 19 (EC 2.3.2.27)	protein	341	5% helix, 47% strand	P32523

Pockets

7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	453	0.76	0.84	58	empty
2	83	0.75	0.97	28	empty
3	357	0.71	0.83	53	empty
4	195	0.59	0.81	26	empty
5	141	0.50	0.79	31	empty

Interfaces

1 interface between chains.

A–B · 975 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

5M8C · Spliceosome component · the same entry in another collection · chain A against A, TM-score 1.00
P32523 · AlphaFold monomer V2.0 prediction for pre-mRNA-processing factor 19 (P32523) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P32523
Elsewhere: RCSB PDB 5M8C · PDBe 5M8C · UniProt P32523

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