MolNFT v1 · #112108 · protein

Spliceosome component

4ZB4 · Pre-mRNA-processing factor 19: “Spliceosome component”. X-ray diffraction, 9 pockets (best druggability 0.77). MolNFT v1 #112108 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4ZB4
Type: protein
Length: 696 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pre-mRNA-processing factor 19
EC: 6.3.2.-
UniProt: P32523
Pockets: 9 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pre-mRNA-processing factor 19 (EC 6.3.2.-)	protein	354	5% helix, 47% strand	P32523
B	Pre-mRNA-processing factor 19 (EC 6.3.2.-)	protein	342	6% helix, 47% strand	P32523

Pockets

9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	502	0.77	0.84	63	empty
2	87	0.76	0.97	30	empty
3	408	0.74	0.84	46	empty
4	168	0.62	0.84	28	empty
5	155	0.59	0.84	25	empty

Interfaces

1 interface between chains.

A–B · 986 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

4ZB4 · Spliceosome component · the same entry in another collection · chain A against A, TM-score 1.00
P32523 · AlphaFold monomer V2.0 prediction for pre-mRNA-processing factor 19 (P32523) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P32523
Elsewhere: RCSB PDB 4ZB4 · PDBe 4ZB4 · UniProt P32523

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