UniProt P28845
Corticosteroid 11-beta-dehydrogenase isozyme 1 (P28845)
Corticosteroid 11-beta-dehydrogenase isozyme 1 (UniProt P28845), EC 1.1.1.146: 76 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 18 pockets. Binding sites, druggability and experiment against…
- UniProt
- P28845
- Protein
- Corticosteroid 11-beta-dehydrogenase isozyme 1
- EC
- 1.1.1.146
- Experimental structures
- 76
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 18 · 2 records with a druggable one
Structures
77 records of P28845 in the MolNFT archive: 76 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1XU7 | Crystal Structure of the Interface Open Conformation of Tetrameric 11b-HSD1 | x-ray diffraction | A, B, C, D | — | — |
| 1XU7 | Crystal structure of the interface open conformation of tetrameric 11B-HSD1 | x-ray diffraction | A, B, C, D | — | — |
| 1XU9 | Crystal Structure of the Interface Closed Conformation of 11b-hydroxysteroid dehydrogenase isozyme 1 | x-ray diffraction | A, B, C, D | — | — |
| 1XU9 | Crystal structure of the interface closed conformation of 11B- hydroxysteroid dehydrogenase isozyme… | x-ray diffraction | A, B, C, D | — | — |
| 2BEL | Structure of human 11-beta-hydroxysteroid dehydrogenase in complex with NADP and carbenoxolone | x-ray diffraction | A, B, C, D | — | — |
| 2BEL | Structure of human 11-beta-hydroxysteroid dehydrogenase in complex with NADP and carbenoxolone | x-ray diffraction | A, B, C, D | — | — |
| 2ILT | Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Sulfone Inhibitor | x-ray diffraction | A | — | — |
| 2ILT | Human 11-beta-hydroxysteroid dehydrogenase (HSD1) with NADP and adamantane sulfone inhibitor | x-ray diffraction | A | — | — |
| 2IRW | Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Ether Inhibitor | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2IRW | Human 11-beta-hydroxysteroid dehydrogenase (HSD1) with NADP and adamantane ether inhibitor | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2RBE | The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 2RBE | The discovery of 2-anilinothiazolones as 11BETA-HSD1 inhibitors | x-ray diffraction | A, B, C, D | — | — |
| 3BYZ | 2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11-Hydroxysteroid Dehydrogenase Type 1… | x-ray diffraction | A, B, C, D | — | — |
| 3BYZ | 2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11- hydroxysteroid dehydrogenase type 1… | x-ray diffraction | A, B, C, D | — | — |
| 3BZU | Crystal structure of human 11-beta-hydroxysteroid dehydrogenase(HSD1) in complex with NADP and… | x-ray diffraction | A, B, C, D | — | — |
| 3BZU | Crystal structure of human 11-beta-hydroxysteroid DEHYDROGENASE(HSD1) in complex with NADP and… | x-ray diffraction | A, B, C, D | — | — |
| 3CH6 | Crystal Structure of 11beta-HSD1 Double Mutant (L262R, F278E) Complexed with… | x-ray diffraction | A, B, D, E | — | — |
| 3CH6 | Crystal structure of 11BETA-HSD1 double mutant (L262R, F278E) complexed with… | x-ray diffraction | A, B, D, E | — | — |
| 3CZR | Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) in Complex with… | x-ray diffraction | A, B | — | — |
| 3CZR | Crystal structure of human 11-beta-hydroxysteroid dehydrogenase (HSD1) in complex with… | x-ray diffraction | A, B | — | — |
| 3D3E | Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) in Complex with Benzamide… | x-ray diffraction | A, B, C, D | — | — |
| 3D3E | Crystal structure of human 11-beta-hydroxysteroid dehydrogenase (HSD1) in complex with benzamide… | x-ray diffraction | A, B, C, D | — | — |
| 3D4N | Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) in Complex with Sulfonamide… | x-ray diffraction | A, B, C, D | — | — |
| 3D4N | Crystal structure of human 11-beta-hydroxysteroid dehydrogenase (HSD1) in complex with sulfonamide… | x-ray diffraction | A, B, C, D | — | — |
| 3D5Q | Crystal Structure of 11b-HSD1 in Complex with Triazole Inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 3D5Q | Crystal structure of 11B-HSD1 in complex with triazole inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 3EY4 | Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11-hydroxysteroid dehydrogenase… | x-ray diffraction | A, B, C, D | — | — |
| 3EY4 | Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11- hydroxysteroid dehydrogenase… | x-ray diffraction | A, B, C, D | — | — |
| 3FCO | Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with Benzamide… | x-ray diffraction | A, B | — | — |
| 3FCO | Crystal structure of 11BETA-hydroxysteroid dehydrogenase 1 (11B-HSD1) in complex with benzamide… | x-ray diffraction | A, B | — | — |
| 3FRJ | Crystal Structure of 11b-Hydroxysteroid Dehydrogenase-1 (11b-HSD1) in Complex with Piperidyl… | x-ray diffraction | A, B | — | — |
| 3FRJ | Crystal structure of 11B-hydroxysteroid dehydrogenase-1 (11B-HSD1) in complex with piperidyl… | x-ray diffraction | A, B | — | — |
| 3H6K | Crystal Structure of Human 11-beta-hydroxysteroid-dehydrogenase Bound to an… | x-ray diffraction | A, B, C, D | — | — |
| 3H6K | Crystal structure of human 11-beta-hydroxysteroid-dehydrogenase bound to an… | x-ray diffraction | A, B, C, D | — | — |
| 3HFG | Crystal Structure of Human 11-beta-hydroxysteroid-dehydrogenase Bound to an Sulfonyl-piperazine… | x-ray diffraction | A, B, C, D | — | — |
| 3HFG | Crystal structure of human 11-beta-hydroxysteroid-dehydrogenase bound to an sulfonyl-piperazine… | x-ray diffraction | A, B, C, D | — | — |
| 3OQ1 | Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase-1 (11b-HSD1) in Complex with Diarylsulfone… | x-ray diffraction | A, B, C, D | — | — |
| 3OQ1 | Crystal structure of 11BETA-hydroxysteroid dehydrogenase-1 (11B-HSD1) in complex with diarylsulfone… | x-ray diffraction | A, B, C, D | — | — |
| 3PDJ | Crystal Structure of Human 11-beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with… | x-ray diffraction | A, B | — | — |
| 3PDJ | Crystal structure of human 11-beta-hydroxysteroid dehydrogenase 1 (11B-HSD1) in complex with… | x-ray diffraction | A, B | — | — |
| 3QQP | Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with Urea Inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 3QQP | Crystal structure of 11BETA-hydroxysteroid dehydrogenase 1 (11B-HSD1) in complex with urea inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 3TFQ | Crystal structure of 11b-hsd1 double mutant (l262r, f278e) complexed with… | x-ray diffraction | A, B, D, E | — | — |
| 3TFQ | Crystal structure of 11B-HSD1 double mutant (L262R, F278E) complexed with… | x-ray diffraction | A, B, D, E | — | — |
| 4BB5 | Free-Wilson and Structural Approaches to Co-optimising Human and Rodent Isoform Potency for… | x-ray diffraction | A, B, C, D | — | — |
| 4BB5 | Free-wilson and structural approaches to co-optimising human and rodent isoform potency for… | x-ray diffraction | A, B, C, D | — | — |
| 4BB6 | Free-Wilson and Structural Approaches to Co-optimising Human and Rodent Isoform Potency for… | x-ray diffraction | A, B | — | — |
| 4BB6 | Free-wilson and structural approaches to co-optimising human and rodent isoform potency for… | x-ray diffraction | A, B | — | — |
| 4C7J | 11b-Hydroxysteroid Dehydrogenase Type I in complex with inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4C7J | 11B-hydroxysteroid dehydrogenase type I in complex with inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4C7K | 11b-Hydroxysteroid Dehydrogenase Type I in complex with inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4C7K | 11B-hydroxysteroid dehydrogenase type I in complex with inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4HFR | Human 11beta-Hydroxysteroid Dehydrogenase Type 1 in complex with an orally bioavailable acidic… | x-ray diffraction | A, B | — | — |
| 4HFR | Human 11BETA-hydroxysteroid dehydrogenase type 1 in complex with an orally bioavailable acidic… | x-ray diffraction | A, B | — | — |
| 4HX5 | Crystal structure of 11 beta-HSD1 in complex with SAR184841 | x-ray diffraction | A, B, C, D | — | — |
| 4HX5 | Crystal structure of 11 beta-HSD1 in complex with SAR184841 | x-ray diffraction | A, B, C, D | — | — |
| 4IJU | Crystal structure of 11b-HSD1 double mutant (L262R, F278E) in complex with… | x-ray diffraction | A, B, D, E | — | — |
| 4IJU | Crystal structure of 11B-HSD1 double mutant (L262R, F278E) in complex with… | x-ray diffraction | A, B, D, E | — | — |
| 4IJV | Crystal structure of 11b-HSD1 double mutant (L262R, F278E) in complex with… | x-ray diffraction | A, B, D, E | — | — |
| 4IJV | Crystal structure of 11B-HSD1 double mutant (L262R, F278E) in complex with… | x-ray diffraction | A, B, D, E | — | — |
17 records more on the page itself.
Ligands
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 9 records
- 8K7 · 1-(3-hydroxyazetidin-1-yl)-2-[(2S,5R)-2-(4-fluorophenyl)-5-methoxyadamantan-2-yl]ethan-1-one · in 2 records
- 4JX · N-[(1R,2s,3S,5s,7s)-5-hydroxytricyclo[3.3.1.1~3,7~]dec-2-yl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxamide · in 1 record
- 7H6 · (1S,4S,5S,9S)-9-hydroxy-8-methyl-4-(propan-2-yl) spiro[4.5]dec-7-ene-1-carboxylic acid · in 1 record
- 8K4 · 2-[2-(4-fluorophenyl)-2-adamantyl]-1-(3-methoxyazetidin-1-yl)ethanone · in 1 record
- 8KA · 2-[(1R,3S,5R,7S)-2-[4-(4-fluorophenyl)phenyl]-6-hydroxyadamantan-2-yl]-1-(3-hydroxyazetidin-1-yl) ethan-1-one · in 1 record
- 8KD · 2-(2-benzyl-6-hydroxyadamantan-2-yl)-1-(3-hydroxyazetidin-1-yl)ethan-1-one · in 1 record
- 8KG · 2-[(5R,7S)-6-hydroxy-2-phenyladamantan-2-yl]-1-(3-hydroxyazetidin-1-yl)ethan-1-one · in 1 record
- HJG · 2-{3-[1-(4-chlorophenyl)cyclopropyl][1,2,4]triazolo[4, 3-a]pyridin-8-yl}propan-2-ol · in 1 record
Experiment against prediction
- 2IRW chain C against the predicted model P28845: TM-score 1.00, RMSD 0.28 Å
- 2IRW chain C against the predicted model P28845: TM-score 1.00, RMSD 0.28 Å
- 4BB5 chain D against the predicted model P28845: TM-score 1.00, RMSD 0.29 Å
- 4BB5 chain D against the predicted model P28845: TM-score 1.00, RMSD 0.29 Å
- 4BB5 chain C against the predicted model P28845: TM-score 1.00, RMSD 0.29 Å
- 4BB5 chain C against the predicted model P28845: TM-score 1.00, RMSD 0.29 Å
- 2IRW chain E against the predicted model P28845: TM-score 1.00, RMSD 0.31 Å
- 2IRW chain E against the predicted model P28845: TM-score 1.00, RMSD 0.31 Å
- 2IRW chain D against the predicted model P28845: TM-score 1.00, RMSD 0.32 Å
- 2IRW chain D against the predicted model P28845: TM-score 1.00, RMSD 0.32 Å
Elsewhere
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