UniProt P28482
Mitogen-activated protein kinase 1 (P28482)
Mitogen-activated protein kinase 1 (UniProt P28482), EC 2.7.11.24: 231 experimental structures on GenesisL1, 95 ligands bound, 196 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P28482
- Protein
- Mitogen-activated protein kinase 1
- EC
- 2.7.11.24
- Experimental structures
- 231
- Predicted models
- 0
- Ligands
- 95
- Pockets
- 196 · 53 records with a druggable one
Structures
231 records of P28482 in the MolNFT archive: 231 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1PME | Structure of penta mutant human ERK2 MAP kinase complexed with a specific inhibitor of human P38… | x-ray diffraction | A | — | — |
| 1PME | Structure of penta mutant human ERK2 MAP kinase complexed with a specific inhibitor of human P38… | x-ray diffraction | A | — | — |
| 1TVO | The structure of ERK2 in complex with a small molecule inhibitor | x-ray diffraction | A | — | — |
| 1TVO | The structure of ERK2 in complex with a small molecule inhibitor | x-ray diffraction | A | — | — |
| 1WZY | Crystal structure of human ERK2 complexed with a pyrazolopyridazine derivative | x-ray diffraction | A | — | — |
| 1WZY | Crystal structure of human ERK2 complexed with a pyrazolopyridazine derivative | x-ray diffraction | A | — | — |
| 2OJG | Crystal structure of ERK2 in complex with N,N-dimethyl-4-(4-phenyl-1H-pyrazol-3-yl)-1H-pyrrole-2-car… | x-ray diffraction | A | — | — |
| 2OJG | Crystal structure of ERK2 in complex with N,N-dimethyl-4-(4… | x-ray diffraction | A | — | — |
| 2OJI | Crystal structure of ERK2 in complex with N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole… | x-ray diffraction | A | — | — |
| 2OJI | Crystal structure of ERK2 in complex with N-benzyl-4-(4-(3… | x-ray diffraction | A | — | — |
| 2OJJ | Crystal structure of ERK2 in complex with (S)-N-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3… | x-ray diffraction | A | — | — |
| 2OJJ | Crystal structure of ERK2 in complex with (S)-N-(1-(3-chloro-4… | x-ray diffraction | A | — | — |
| 2Y9Q | Crystal structure of human ERK2 complexed with a MAPK docking peptide | x-ray diffraction | A | — | — |
| 2Y9Q | Crystal structure of human ERK2 complexed with a MAPK docking peptide | x-ray diffraction | A | — | — |
| 3D42 | Crystal structure of HePTP in complex with a monophosphorylated Erk2 peptide | x-ray diffraction | B | — | — |
| 3D42 | Crystal structure of heptp in complex with a monophosphorylated ERK2 peptide | x-ray diffraction | B | — | — |
| 3D44 | Crystal structure of HePTP in complex with a dually phosphorylated Erk2 peptide mimetic | x-ray diffraction | B | — | — |
| 3D44 | Crystal structure of heptp in complex with a dually phosphorylated ERK2 peptide mimetic | x-ray diffraction | B | — | — |
| 3I5Z | Crystal structure of ERK2 bound to (S)-N-(2-hydroxy-1-phenylethyl)-4-(5-methyl-2-(phenylamino)pyrimi… | x-ray diffraction | A | — | — |
| 3I5Z | Crystal structure of ERK2 bound to (S)-N-(2-hydroxy-1-phenylethyl)-4… | x-ray diffraction | A | — | — |
| 3I60 | Crystal structure of ERK2 bound to (S)-4-(2-(2-chlorophenylamino)-5-methylpyrimidin-4-yl)-N-(2-hydro… | x-ray diffraction | A | — | — |
| 3I60 | Crystal structure of ERK2 bound to (S)-4-(2-(2-chlorophenylamino)-5… | x-ray diffraction | A | — | — |
| 3SA0 | Complex of ERK2 with norathyriol | x-ray diffraction | A | — | — |
| 3SA0 | Complex of ERK2 with norathyriol | x-ray diffraction | A | — | — |
| 3TEI | Crystal structure of human ERK2 complexed with a MAPK docking peptide | x-ray diffraction | A | — | — |
| 3TEI | Crystal structure of human ERK2 complexed with a MAPK docking peptide | x-ray diffraction | A | — | — |
| 3W55 | The structure of ERK2 in complex with FR148083 | x-ray diffraction | A | — | — |
| 3W55 | The structure of ERK2 in complex with FR148083 | x-ray diffraction | A | — | — |
| 4FMQ | Crystal structure of human ERK2 complexed with a MAPK docking peptide | x-ray diffraction | A | — | — |
| 4FMQ | Crystal structure of human ERK2 complexed with a MAPK docking peptide | x-ray diffraction | A | — | — |
| 4FUX | Crystal Structure of the ERK2 complexed with E75 | x-ray diffraction | A | — | — |
| 4FUX | Crystal structure of the ERK2 complexed with E75 | x-ray diffraction | A | — | — |
| 4FUY | Crystal Structure of the ERK2 complexed with EK2 | x-ray diffraction | A | — | — |
| 4FUY | Crystal structure of the ERK2 complexed with EK2 | x-ray diffraction | A | — | — |
| 4FV0 | Crystal Structure of the ERK2 complexed with EK3 | x-ray diffraction | A | — | — |
| 4FV0 | Crystal structure of the ERK2 complexed with EK3 | x-ray diffraction | A | — | — |
| 4FV1 | Crystal Structure of the ERK2 complexed with EK4 | x-ray diffraction | A | — | — |
| 4FV1 | Crystal structure of the ERK2 complexed with EK4 | x-ray diffraction | A | — | — |
| 4FV2 | Crystal Structure of the ERK2 complexed with EK5 | x-ray diffraction | A | — | — |
| 4FV2 | Crystal structure of the ERK2 complexed with EK5 | x-ray diffraction | A | — | — |
| 4FV3 | Crystal Structure of the ERK2 complexed with EK6 | x-ray diffraction | A | — | — |
| 4FV3 | Crystal structure of the ERK2 complexed with EK6 | x-ray diffraction | A | — | — |
| 4FV4 | Crystal Structure of the ERK2 complexed with EK7 | x-ray diffraction | A | — | — |
| 4FV4 | Crystal structure of the ERK2 complexed with EK7 | x-ray diffraction | A | — | — |
| 4FV5 | Crystal Structure of the ERK2 complexed with EK9 | x-ray diffraction | A | — | — |
| 4FV5 | Crystal structure of the ERK2 complexed with EK9 | x-ray diffraction | A | — | — |
| 4FV6 | Crystal Structure of the ERK2 complexed with E57 | x-ray diffraction | A | — | — |
| 4FV6 | Crystal structure of the ERK2 complexed with E57 | x-ray diffraction | A | — | — |
| 4FV7 | Crystal Structure of the ERK2 complexed with E94 | x-ray diffraction | A | — | — |
| 4FV7 | Crystal structure of the ERK2 complexed with E94 | x-ray diffraction | A | — | — |
| 4FV8 | Crystal Structure of the ERK2 complexed with E63 | x-ray diffraction | A | — | — |
| 4FV8 | Crystal structure of the ERK2 complexed with E63 | x-ray diffraction | A | — | — |
| 4FV9 | Crystal Structure of the ERK2 complexed with E71 | x-ray diffraction | A | — | — |
| 4FV9 | Crystal structure of the ERK2 complexed with E71 | x-ray diffraction | A | — | — |
| 4G6N | Crystal Structure of the ERK2 | x-ray diffraction | A | — | — |
| 4G6N | Crystal structure of the ERK2 | x-ray diffraction | A | — | — |
| 4G6O | Crystal Structure of the ERK2 | x-ray diffraction | A | — | — |
| 4G6O | Crystal structure of the ERK2 | x-ray diffraction | A | — | — |
| 4H3P | Crystal structure of human ERK2 complexed with a MAPK docking peptide | x-ray diffraction | A, D | — | — |
| 4H3P | Crystal structure of human ERK2 complexed with a MAPK docking peptide | x-ray diffraction | A, D | — | — |
171 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 94 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 6 records
- 5ID · (2R,3R,4S,5R)-2-(4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3, 4-diol · in 5 records
- 6QB · 1-[(1~{S})-1-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanyl-ethyl]-4-[2-[(2-methylpyrazol-3-yl) amino]pyrimidin-4-yl]pyridin-2-one · in 3 records
- MG · Magnesium ion · in 3 records
- 6GI · 13-[4-({imidazo[1,2-a]pyridin-2-yl}methoxy)phenyl]-4,8-dioxa-12,14,16,18-tetraazatetracyclo[9.7.0.0^{3, 9}.0^{12,17}]octadeca-1(11),2,9,15,17-pentaen-15-amine · in 2 records
- 6H3 · N-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl) phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide · in 2 records
- 6TS · [(1~{R},4~{Z})-cyclooct-4-en-1-yl] ~{N}-[4-[4-[[5-chloranyl-4-[[2-(propanoylamino) phenyl]amino]pyrimidin-2-yl]amino]pyridin-2-yl]but-3-ynyl]carbamate · in 2 records
- 6TT · ~{N}-[2-[[2-[(5-methoxypyridin-3-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]propanamide · in 2 records
- 8QB · 7-[2-(oxan-4-ylamino)pyrimidin-4-yl]-3,4-dihydro-2~{H}-pyrrolo[1,2-a]pyrazin-1-one · in 2 records
- 8X2 · 2-[2-[[4-(4-methylpiperazin-1-yl) phenyl]amino]pyrimidin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one · in 2 records
- 8X5 · 2-[2-(oxan-4-ylamino)pyrimidin-4-yl]-5-(phenylmethyl)-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one · in 2 records
- 8XB · (6~{R})-5-(2-methoxyethyl)-6-methyl-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one · in 2 records
- 8XE · 5-(2-methoxyethyl)-2-[2-[(2-methylpyrazol-3-yl) amino]pyrimidin-4-yl]-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one · in 2 records
- 8XH · 5-(2-methoxyethyl)-2-[2-(oxan-4-ylamino)pyrimidin-4-yl]-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one · in 2 records
- 8XK · 5-(2-methoxyethyl)-1-methyl-2-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-6,7-dihydropyrrolo[3,2-c]pyridin-4-one · in 2 records
- 8XN · (6~{S})-5-(2-methoxyethyl)-6-methyl-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one · in 2 records
- ACP · Phosphomethylphosphonic acid adenylate ester · in 2 records
- AN2 · Amp phosphoramidate · in 2 records
- CL · Chloride ion · in 2 records
- EQZ · 6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-(2-methoxyethyl)-3~{H}-isoindol-1-one · in 2 records
- ER8 · ~{N}-~{tert}-butyl-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]ethanamide · in 2 records
- ERK · 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{R})-1-phenylethyl]ethanamide · in 2 records
- ERW · ~{N}-~{tert}-butyl-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-methyl-ethanamide · in 2 records
- ESK · 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{S})-2-oxidanyl-1-phenyl-ethyl]ethanamide · in 2 records
- ESW · 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-(2-phenylpropan-2-yl)ethanamide · in 2 records
- EVK · 4-[5-chloranyl-2-(propan-2-ylamino)pyridin-4-yl]-~{N}-[(1~{S})-1-(3-chlorophenyl)-2-oxidanyl-ethyl]-1~{H}-pyrrole-2-carboxamide · in 2 records
- EVQ · 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{R})-1-(3-methoxyphenyl)ethyl]ethanamide · in 2 records
- F0E · cyclooctyl ~{N}-[3-[[4-[5-[[(3~{R})-1-[2-oxidanylidene-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]pyrrolidin-3-yl]carbonylamino]-1~{H}-indazol-3-yl]pyridin-2-yl]carbonylamino]propyl]carbamate · in 2 records
- F0H · [(1~{R},4~{Z})-cyclooct-4-en-1-yl] ~{N}-[4-[4-[[4-[1-[(1~{S})-1-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanyl-ethyl]-2-oxidanylidene-pyridin-4-yl]pyrimidin-2-yl]amino]pyridin-2-yl]but-3-ynyl]carbamate · in 2 records
Elsewhere
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