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Ligand · FRZ

FRZ · 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3, 4-c]pyridazin-3-amine

FRZ, 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3, 4-c]pyridazin-3-amine (C18 H13 N7, 327.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the…

Component
FRZ
Formula
C18 H13 N7
Class
ligand
Structures
2
PDB entries
2

Binding sites

FRZ in 2 structures; the first of them:

  • 5V61 · Phospho-ERK2 bound to bivalent inhibitor SBP2 · FRZ I801 · binds TYR36, VAL39, ALA52, ILE53, LYS54, ILE84, ILE103, GLN105 and 6 more
  • 5V62 · Phospho-ERK2 bound to bivalent inhibitor SBP3 · FRZ A406 · binds VAL39, ALA52, ILE53, LYS54, ILE84, ILE103, GLN105, ASP106 and 5 more

Residues it binds most

ILE 2, ASP 2, LEU 2, ALA 2, ASN 2, GLN 2, LYS 2, MET 2, VAL 2, TYR 1 (residue and the binding sites it lines).

Found with

  • GOL · Glycerol
  • 90A · 2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid
  • AKS · N-(hex-5-yn-1-yl)hexanamide

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