MolNFT v1 · #136860 · protein

Phospho-ERK2 bound to bivalent inhibitor SBP2

5V61: “Phospho-ERK2 bound to bivalent inhibitor SBP2”. X-ray diffraction, 2 ligands (FRZ, 90A). MolNFT v1 #136860 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5V61
Type: protein
Length: 367 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P28482, Q15418, P04608
Ligands: FRZ, 90A

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	350	—	P28482
I	—	protein	17	—	Q15418, P04608

Ligands and binding sites

FRZ · 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3, 4-c]pyridazin-3-amine · ligand · chains A
90A · 2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid · ligand · chains A, I
GOL · Glycerol · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5V61 · Phospho-ERK2 bound to bivalent inhibitor SBP2 · the same entry in another collection · chain A against A, TM-score 1.00
Q15418 · AlphaFold monomer V2.0 prediction for ribosomal protein S6 kinase alpha-1 (Q15418) · a predicted model of the same protein · chain I against A, TM-score 0.38

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P28482
Every structure of UniProt Q15418
Every structure of UniProt P04608
Elsewhere: RCSB PDB 5V61 · PDBe 5V61 · UniProt P28482 · UniProt Q15418 · UniProt P04608

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