UniProt Q15418
Ribosomal protein S6 kinase alpha-1 (Q15418)
Ribosomal protein S6 kinase alpha-1 (UniProt Q15418), EC 2.7.11.1: 35 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q15418
- Protein
- Ribosomal protein S6 kinase alpha-1
- EC
- 2.7.11.1
- Experimental structures
- 35
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 6 · 1 record with a druggable one
Structures
36 records of Q15418 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2WNT | Crystal Structure of the Human Ribosomal protein S6 kinase | x-ray diffraction | A, B | — | — |
| 2WNT | Crystal structure of the human ribosomal protein S6 kinase | x-ray diffraction | A, B | — | — |
| 2Z7Q | Crystal structure of the N-terminal kinase domain of human RSK-1 bound to AMP-PCP | x-ray diffraction | A | — | — |
| 2Z7Q | Crystal structure of the N-terminal kinase domain of human rsk-1 bound to AMP-pcp | x-ray diffraction | A | — | — |
| 2Z7R | Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Staurosporine | x-ray diffraction | A | — | — |
| 2Z7R | Crystal structure of the N-terminal kinase domain of human RSK1 bound to staurosporine | x-ray diffraction | A | — | — |
| 2Z7S | Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Purvalnol A | x-ray diffraction | A | — | — |
| 2Z7S | Crystal structure of the N-terminal kinase domain of human RSK1 bound to purvalnol a | x-ray diffraction | A | — | — |
| 3RNY | Crystal structure of human RSK1 C-terminal kinase domain | x-ray diffraction | A, B | — | — |
| 3RNY | Crystal structure of human RSK1 C-terminal kinase domain | x-ray diffraction | A, B | — | — |
| 3TEI | Crystal structure of human ERK2 complexed with a MAPK docking peptide | x-ray diffraction | B | — | — |
| 3TEI | Crystal structure of human ERK2 complexed with a MAPK docking peptide | x-ray diffraction | B | — | — |
| 4H3P | Crystal structure of human ERK2 complexed with a MAPK docking peptide | x-ray diffraction | B, E | — | — |
| 4H3P | Crystal structure of human ERK2 complexed with a MAPK docking peptide | x-ray diffraction | B, E | — | — |
| 4NIF | Heterodimeric structure of ERK2 and RSK1 | x-ray diffraction | A, D | — | — |
| 4NIF | Heterodimeric structure of ERK2 and RSK1 | x-ray diffraction | A, D | — | — |
| 5CSF | S100B-RSK1 crystal structure A | x-ray diffraction | C | — | 3 (best 0.57) |
| 5CSF | S100B-RSK1 crystal structure a | x-ray diffraction | C | — | — |
| 5CSI | S100B-RSK1 crystal structure a' | x-ray diffraction | C | — | — |
| 5CSJ | S100B-RSK1 crystal structure B | x-ray diffraction | C | — | 2 (best 0.46) |
| 5CSJ | S100B-RSK1 crystal structure B | x-ray diffraction | C | — | — |
| 5CSN | S100B-RSK1 crystal structure C | x-ray diffraction | C | — | — |
| 5CSN | S100B-RSK1 crystal structure C | x-ray diffraction | C | — | — |
| 5N7D | MAGI-1 complexed with a RSK1 peptide | x-ray diffraction | C | — | — |
| 5N7D | Magi-1 complexed with a RSK1 peptide | x-ray diffraction | C | — | — |
| 5N7F | MAGI-1 complexed with a pRSK1 peptide | x-ray diffraction | C | — | — |
| 5N7F | Magi-1 complexed with a PRSK1 peptide | x-ray diffraction | C | — | — |
| 5N7G | MAGI-1 complexed with a synthetic pRSK1 peptide | x-ray diffraction | C | — | 1 (best 0.29) |
| 5N7G | Magi-1 complexed with a synthetic PRSK1 peptide | x-ray diffraction | C | — | — |
| 5V61 | Phospho-ERK2 bound to bivalent inhibitor SBP2 | x-ray diffraction | I | 90A | — |
| 5V62 | Phospho-ERK2 bound to bivalent inhibitor SBP3 | x-ray diffraction | I | — | — |
| 7P74 | The PDZ domain of SYNJ2BP complexed with the phosphorylated PDZ-binding motif of RSK1 | x-ray diffraction | B | — | — |
| 7P74 | The PDZ domain of SYNJ2BP complexed with the phosphorylated PDZ- binding motif of RSK1 | x-ray diffraction | B | — | — |
| 7PC8 | The PDZ domain of SNTG1 complexed with the phosphomimetic mutant PDZ- binding motif of RSK1 | x-ray diffraction | C, D | — | — |
| 7QQL | The PDZ domain of SNTG2 complexed with the phosphorylated PDZ-binding motif of RSK1 | x-ray diffraction | F, D, E | — | — |
| Q15418 | AlphaFold monomer V2.0 prediction for ribosomal protein S6 kinase alpha-1 (Q15418) | predicted | A | — | — |
Ligands
- 90A · 2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid · in 1 record
Experiment against prediction
- 5N7D chain C against the predicted model Q15418: TM-score 0.99, RMSD 0.05 Å
- 5N7D chain C against the predicted model Q15418: TM-score 0.99, RMSD 0.05 Å
- 2Z7S chain A against the predicted model Q15418: TM-score 0.97, RMSD 1.08 Å
- 2Z7S chain A against the predicted model Q15418: TM-score 0.97, RMSD 1.08 Å
- 2Z7Q chain A against the predicted model Q15418: TM-score 0.97, RMSD 1.10 Å
- 2Z7Q chain A against the predicted model Q15418: TM-score 0.97, RMSD 1.10 Å
- 2Z7R chain A against the predicted model Q15418: TM-score 0.96, RMSD 1.55 Å
- 2Z7R chain A against the predicted model Q15418: TM-score 0.96, RMSD 1.55 Å
- 2WNT chain A against the predicted model Q15418: TM-score 0.96, RMSD 1.39 Å
- 2WNT chain A against the predicted model Q15418: TM-score 0.96, RMSD 1.39 Å
Elsewhere
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