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Ligand · 1FM

1FM · (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione

1FM, (3S,5Z,8S,9S,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione (C19 H22 O7, 362.4 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding…

Component
1FM
Formula
C19 H22 O7
Class
ligand
Structures
6
PDB entries
3

Binding sites

1FM in 6 structures; the first of them:

  • 3W55 · The structure of ERK2 in complex with FR148083 · 1FM A401 · binds ILE31, GLU33, TYR36, VAL39, ALA52, LYS54, GLN105, ASP106 and 11 more
  • 3WZU · THE STRUCTURE OF MAP2K7 IN COMPLEX WITH 5Z-7-oxozeaenol · 1FM A600 · binds MET142, GLY143, GLY145, THR146, CYS147, VAL150, ALA163, LYS165 and 11 more
  • 4GS6 · Irreversible Inhibition of TAK1 Kinase by 5Z-7-Oxozeaenol · 1FM A611 · binds VAL42, GLY43, ARG44, GLY45, VAL50, ALA61, VAL90, MET104 and 10 more
  • 3W55 · The structure of ERK2 in complex with FR148083 · 1FM A401 · binds ILE31, GLU33, TYR36, VAL39, ALA52, LYS54, GLN105, ASP106 and 11 more
  • 3WZU · The structure of MAP2K7 in complex with 5Z-7-oxozeaenol · 1FM A600 · binds MET142, GLY143, GLY145, THR146, CYS147, VAL150, ALA163, LYS165 and 11 more
  • 4GS6 · Irreversible inhibition of TAK1 kinase by 5Z-7-oxozeaenol · 1FM A611 · binds VAL42, GLY43, ARG44, GLY45, VAL50, ALA61, VAL90, MET104 and 10 more

Residues it binds most

GLY 4, VAL 6, LEU 6, MET 6, ALA 6, ASP 4, CYS 6, GLU 6, LYS 4, SER 6 (residue and the binding sites it lines).

Found with

  • EDO · 1,2-ethanediol

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