UniProt P21802
Fibroblast growth factor receptor 2 (P21802)
Fibroblast growth factor receptor 2 (UniProt P21802), EC 2.7.10.1: 85 experimental structures and 1 predicted model on GenesisL1, 13 ligands bound, 38 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P21802
- Protein
- Fibroblast growth factor receptor 2
- EC
- 2.7.10.1
- Experimental structures
- 85
- Predicted models
- 1
- Ligands
- 13
- Pockets
- 38 · 6 records with a druggable one
Structures
86 records of P21802 in the MolNFT archive: 85 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DJS | Ligand-binding portion of fibroblast growth factor receptor 2 in complex with FGF1 | x-ray diffraction | A | — | — |
| 1DJS | Ligand-binding portion of fibroblast growth factor receptor 2 in complex with FGF1 | x-ray diffraction | A | — | — |
| 1E0O | Crystal structure of a ternary FGF1-FGFR2-heparin complex | x-ray diffraction | B, D | — | — |
| 1E0O | Crystal structure of a ternary FGF1-FGFR2-heparin complex | x-ray diffraction | B, D | — | — |
| 1EV2 | Crystal structure of FGF2 in complex with the extracellular ligand binding domain of FGF receptor 2… | x-ray diffraction | E, F, G, H | — | — |
| 1EV2 | Crystal structure of FGF2 in complex with the extracellular ligand binding domain of FGF receptor 2… | x-ray diffraction | E, F, G, H | — | — |
| 1GJO | The FGFr2 tyrosine kinase domain | x-ray diffraction | A | — | — |
| 1GJO | The FGFR2 tyrosine kinase domain | x-ray diffraction | A | — | — |
| 1II4 | Crystal structure of SER252TRP apert mutant FGF receptor 2 (FGFR2) in complex with FGF2 | x-ray diffraction | E, F, G, H | — | — |
| 1II4 | Crystal structure of SER252TRP apert mutant FGF receptor 2 (FGFR2) in complex with FGF2 | x-ray diffraction | E, F, G, H | — | — |
| 1IIL | Crystal structure of PRO253ARG apert mutant FGF receptor 2 (FGFR2) in complex with FGF2 | x-ray diffraction | E, F, G, H | — | — |
| 1IIL | Crystal structure of PRO253ARG apert mutant FGF receptor 2 (FGFR2) in complex with FGF2 | x-ray diffraction | E, F, G, H | — | — |
| 1NUN | Crystal Structure Analysis of the FGF10-FGFR2b Complex | x-ray diffraction | B | — | — |
| 1NUN | Crystal structure analysis of the FGF10-FGFR2B complex | x-ray diffraction | B | — | — |
| 1OEC | FGFr2 kinase domain | x-ray diffraction | A | — | — |
| 1OEC | FGFR2 kinase domain | x-ray diffraction | A | — | — |
| 2PSQ | Crystal Structure of Unphosphorylated Unactivated Wild Type FGF Receptor 2 (FGFR2) Kinase Domain | x-ray diffraction | A, B | — | — |
| 2PSQ | Crystal structure of unphosphorylated unactivated wild type FGF receptor 2 (FGFR2) kinase domain | x-ray diffraction | A, B | — | — |
| 2PVF | Crystal Structure of Tyrosine Phosphorylated Activated FGF Receptor 2 (FGFR2) Kinase Domain in… | x-ray diffraction | A, B | — | — |
| 2PVF | Crystal structure of tyrosine phosphorylated activated FGF receptor 2 (FGFR2) kinase domain in… | x-ray diffraction | A, B | — | — |
| 2PVY | Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation… | x-ray diffraction | A, B, C, D | — | — |
| 2PVY | Crystal structure of FGF receptor 2 (FGFR2) kinase domain harboring the pathogenic K659N mutation… | x-ray diffraction | A, B, C, D | — | — |
| 2PWL | Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549H Mutation… | x-ray diffraction | A, B | — | — |
| 2PWL | Crystal structure of FGF receptor 2 (FGFR2) kinase domain harboring the pathogenic N549H mutation… | x-ray diffraction | A, B | — | — |
| 2PY3 | Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565G Mutation… | x-ray diffraction | A, B | — | — |
| 2PY3 | Crystal structure of FGF receptor 2 (FGFR2) kinase domain harboring the pathogenic E565G mutation… | x-ray diffraction | A, B | — | — |
| 2PZ5 | Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation… | x-ray diffraction | A, B | — | — |
| 2PZ5 | Crystal structure of FGF receptor 2 (FGFR2) kinase domain harboring the pathogenic N549T mutation… | x-ray diffraction | A, B | — | — |
| 2PZP | Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation… | x-ray diffraction | A, B | — | — |
| 2PZP | Crystal structure of FGF receptor 2 (FGFR2) kinase domain harboring the pathogenic K526E mutation… | x-ray diffraction | A, B | — | — |
| 2PZR | Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K641R Mutation… | x-ray diffraction | A, B | — | — |
| 2PZR | Crystal structure of FGF receptor 2 (FGFR2) kinase domain harboring the pathogenic K641R mutation… | x-ray diffraction | A, B | — | — |
| 2Q0B | Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565A Mutation… | x-ray diffraction | A, B | — | — |
| 2Q0B | Crystal structure of FGF receptor 2 (FGFR2) kinase domain harboring the pathogenic E565A mutation… | x-ray diffraction | A, B | — | — |
| 3B2T | Structure of phosphotransferase | x-ray diffraction | A, B | — | — |
| 3B2T | Structure of phosphotransferase | x-ray diffraction | A, B | — | — |
| 3CAF | Crystal Structure of hFGFR2 D2 Domain | x-ray diffraction | A | — | — |
| 3CAF | Crystal structure of HFGFR2 D2 domain | x-ray diffraction | A | — | — |
| 3CLY | Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domains Trapped in Trans-Phosphorylation Reaction | x-ray diffraction | A | — | — |
| 3CLY | Crystal structure of FGF receptor 2 (FGFR2) kinase domains trapped in trans-phosphorylation reaction | x-ray diffraction | A | — | — |
| 3CU1 | Crystal Structure of 2:2:2 FGFR2D2:FGF1:SOS complex | x-ray diffraction | A, C | — | — |
| 3CU1 | Crystal structure of 2:2:2 FGFR2D2:FGF1:SOS complex | x-ray diffraction | A, C | — | — |
| 3DAR | Crystal structure of D2 domain from human FGFR2 | x-ray diffraction | A, B | — | — |
| 3DAR | Crystal structure of D2 domain from human FGFR2 | x-ray diffraction | A, B | — | — |
| 3EUU | Crystal structure of the FGFR2 D2 domain | x-ray diffraction | A, B | — | — |
| 3EUU | Crystal structure of the FGFR2 D2 domain | x-ray diffraction | A, B | — | — |
| 3OJ2 | Crystal structure of FGF1 complexed with the ectodomain of FGFR2b harboring the A172F Pfeiffer… | x-ray diffraction | C, D | — | — |
| 3OJ2 | Crystal structure of FGF1 complexed with the ectodomain of FGFR2B harboring the A172F pfeiffer… | x-ray diffraction | C, D | — | — |
| 3OJM | Crystal Structure of FGF1 complexed with the ectodomain of FGFR2b harboring P253R Apert mutation | x-ray diffraction | B | — | — |
| 3OJM | Crystal structure of FGF1 complexed with the ectodomain of FGFR2B harboring P253R apert mutation | x-ray diffraction | B | — | — |
| 3RI1 | Crystal structure of the catalytic domain of FGFR2 kinase in complex with ARQ 069 | x-ray diffraction | A, B | — | — |
| 3RI1 | Crystal structure of the catalytic domain of FGFR2 kinase in complex with arq 069 | x-ray diffraction | A, B | — | — |
| 4J23 | Low resolution crystal structure of the FGFR2D2D3/FGF1/SR128545 complex | x-ray diffraction | A | — | — |
| 4J23 | Low resolution crystal structure of the FGFR2D2D3/FGF1/SR128545 complex | x-ray diffraction | A | — | — |
| 4J95 | Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation… | x-ray diffraction | A, B, C, D | — | — |
| 4J95 | Crystal structure of FGF receptor 2 (FGFR2) kinase domain harboring the pathogenic K659N mutation… | x-ray diffraction | A, B, C, D | — | — |
| 4J96 | Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function… | x-ray diffraction | A, B | — | — |
| 4J96 | Crystal structure of FGF receptor 2 (FGFR2) kinase domain harboring the pathogenic gain-of-function… | x-ray diffraction | A, B | — | — |
| 4J97 | Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function… | x-ray diffraction | A, B, C, D | — | — |
| 4J97 | Crystal structure of FGF receptor 2 (FGFR2) kinase domain harboring the pathogenic gain-of-function… | x-ray diffraction | A, B, C, D | — | — |
26 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 9 records
- ACP · Phosphomethylphosphonic acid adenylate ester · in 6 records
- MG · Magnesium ion · in 5 records
- EVC · N-ethyl-2-[[4-[[4-(4-methylpiperazin-1-yl)-3-(2-morpholin-4-ylethoxy)phenyl]amino]-1,3,5-triazin-2-yl]amino]benzenesulfonamide · in 2 records
- EVL · N-ethyl-2-[[4-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-1,3,5-triazin-2-yl]amino]benzenesulfonamide · in 2 records
- NA · Sodium ion · in 2 records
- WFD · 1-[4-(4-{4-(4-methylpiperazin-1-yl)-6-[(3-methyl-1H-pyrazol-5-yl)amino]pyrimidin-2-yl}phenyl)piperidin-1-yl]prop-2-en-1-one · in 2 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 1 record
- GSH · Glutathione · in 1 record
- U9P · (5M)-N-methyl-5-{(6M,8S)-5-{[(3S)-oxolan-3-yl]amino}-6-[1-(propan-2-yl)-1H-pyrazol-3-yl]pyrazolo[1,5-a]pyrimidin-3-yl}pyridine-3-carboxamide · in 1 record
- WCJ · N-{4-[(5P)-4-amino-5-{3-fluoro-4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl}-2-methylpropanamide · in 1 record
- WF7 · N-{4-[(E)-2-{4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}ethenyl]phenyl}prop-2-enamide · in 1 record
- WXQ · N-{4-[4-amino-5-(4-methoxyphenyl)-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl}prop-2-enamide · in 1 record
Experiment against prediction
- 4J95 chain D against the predicted model P21802: TM-score 0.99, RMSD 0.63 Å
- 4J95 chain D against the predicted model P21802: TM-score 0.99, RMSD 0.63 Å
- 4J99 chain D against the predicted model P21802: TM-score 0.99, RMSD 0.67 Å
- 4J99 chain D against the predicted model P21802: TM-score 0.99, RMSD 0.67 Å
- 4J95 chain B against the predicted model P21802: TM-score 0.99, RMSD 0.73 Å
- 4J95 chain B against the predicted model P21802: TM-score 0.99, RMSD 0.73 Å
- 5UHN chain B against the predicted model P21802: TM-score 0.99, RMSD 0.68 Å
- 5UHN chain B against the predicted model P21802: TM-score 0.99, RMSD 0.68 Å
- 4J95 chain C against the predicted model P21802: TM-score 0.99, RMSD 0.73 Å
- 4J95 chain C against the predicted model P21802: TM-score 0.99, RMSD 0.73 Å
Elsewhere
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