UniProt P15208
Insulin receptor (P15208)
Insulin receptor (UniProt P15208), EC 2.7.10.1: 18 experimental structures and 1 predicted model on GenesisL1, 95 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P15208
- Protein
- Insulin receptor
- EC
- 2.7.10.1
- Experimental structures
- 18
- Predicted models
- 1
- Pockets
- 95 · 6 records with a druggable one
Structures
19 records of P15208 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1LK2 | 1.35A crystal structure of H-2Kb complexed with the GNYSFYAL peptide | x-ray diffraction | P | — | — |
| 1LK2 | 1.35A crystal structure of H-2KB complexed with the gnysfyal peptide | x-ray diffraction | P | — | — |
| 7SL1 | Full-length insulin receptor bound with site 1 binding deficient mutant insulin (a-V3E) | electron microscopy | A, B | — | — |
| 7SL2 | Full-length insulin receptor bound with site 2 binding deficient mutant insulin (a-L13R)… | electron microscopy | A, B | — | — |
| 7SL3 | Full-length insulin receptor bound with site 2 binding deficient mutant insulin (a-L13R)… | electron microscopy | A, B | — | — |
| 7SL4 | Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R)… | electron microscopy | A, B | — | — |
| 7SL6 | Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R)… | electron microscopy | A, B | — | 18 (best 0.76) |
| 7SL6 | Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R)… | electron microscopy | A, B | — | — |
| 7SL7 | Full-length insulin receptor bound with both site 1 binding deficient mutant insulin (A-V3E) and… | electron microscopy | A, B | — | 16 (best 0.77) |
| 7SL7 | Full-length insulin receptor bound with both site 1 binding deficient mutant insulin (a-V3E) and… | electron microscopy | A, B | — | — |
| 7STH | Full-length insulin receptor bound with unsaturated insulin WT (2 insulin bound) symmetric… | electron microscopy | A, B | — | 16 (best 0.76) |
| 7STH | Full-length insulin receptor bound with unsaturated insulin wt (2 insulin bound) symmetric… | electron microscopy | A, B | — | — |
| 7STI | Full-length insulin receptor bound with unsaturated insulin wt (1 insulin bound) asymmetric… | electron microscopy | A, B | — | — |
| 7STJ | Full-length insulin receptor bound with unsaturated insulin wt (2 insulins bound) asymmetric… | electron microscopy | A, B | — | — |
| 7STK | Full-length insulin receptor bound with unsaturated insulin WT (2 insulins bound) asymmetric… | electron microscopy | A, B | — | 19 (best 0.84) |
| 7STK | Full-length insulin receptor bound with unsaturated insulin wt (2 insulins bound) asymmetric… | electron microscopy | A, B | — | — |
| 8DTM | Cryo-EM structure of insulin receptor (IR) bound with S597 component 2 | electron microscopy | A, B | — | 6 (best 0.71) |
| 8EYX | Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha… | electron microscopy | A, B | — | 20 (best 0.81) |
| P15208 | AlphaFold monomer V2.0 prediction for insulin receptor (P15208) | predicted | A | — | — |
Experiment against prediction
- 8DTM chain B against the predicted model P15208: TM-score 0.90, RMSD 1.74 Å
- 8DTM chain A against the predicted model P15208: TM-score 0.89, RMSD 3.05 Å
- 7STK chain A against the predicted model P15208: TM-score 0.81, RMSD 4.29 Å
- 7STK chain A against the predicted model P15208: TM-score 0.81, RMSD 4.29 Å
- 7STJ chain A against the predicted model P15208: TM-score 0.72, RMSD 4.92 Å
- 7SL4 chain A against the predicted model P15208: TM-score 0.71, RMSD 4.96 Å
- 8EYX chain B against the predicted model P15208: TM-score 0.71, RMSD 4.34 Å
- 7STI chain A against the predicted model P15208: TM-score 0.67, RMSD 4.92 Å
- 7SL2 chain A against the predicted model P15208: TM-score 0.66, RMSD 5.18 Å
- 7SL1 chain A against the predicted model P15208: TM-score 0.61, RMSD 4.84 Å
Elsewhere
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