MolNFT v1 · #187724 · protein
Full-length insulin receptor bound with unsaturated insulin wt (1 insulin bound) asymmetric conformation
7STI: “Full-length insulin receptor bound with unsaturated insulin wt (1 insulin bound) asymmetric conformation”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #187724 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7STI
- Type
- protein
- Length
- 1,678 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin receptor; Insulin
- EC
- 2.7.10.1
- UniProt
- P15208, P01308
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 3 distinct chains · 11% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin receptor (EC 2.7.10.1) | protein | 816 | 10% helix, 29% strand | P15208 |
| B | Insulin receptor (EC 2.7.10.1) | protein | 814 | 11% helix, 31% strand | P15208 |
| C | Insulin | protein | 48 | 48% helix, 4% strand | P01308 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 375 | 0.86 | 0.94 | 49 | empty |
| 2 | 188 | 0.83 | 0.96 | 41 | empty |
| 3 | 410 | 0.75 | 0.85 | 44 | empty |
| 4 | 436 | 0.74 | 0.83 | 58 | empty |
| 5 | 56 | 0.72 | 0.97 | 18 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2436 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 745 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 460 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 36 disulfide (disulfide).
Compared structures
- 7STI · Full-length insulin receptor bound with unsaturated insulin WT (1 insulin bound)… · the same entry in another collection · chain A against A, TM-score 1.00
- P15208 · AlphaFold monomer V2.0 prediction for insulin receptor (P15208) · a predicted model of the same protein · chain A against A, TM-score 0.67
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15208
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 7STI · PDBe 7STI · UniProt P15208 · UniProt P01308
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