UniProt P01308
Insulin (P01308)
Insulin (UniProt P01308): 573 experimental structures and 1 predicted model on GenesisL1, 20 ligands bound, 79 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P01308
- Protein
- Insulin
- Experimental structures
- 573
- Predicted models
- 1
- Ligands
- 20
- Pockets
- 79 · 16 records with a druggable one
Structures
574 records of P01308 in the MolNFT archive: 573 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A7F | Insulin mutant B16 glu, B24 gly, des-B30, NMR, 20 structures | solution nmr | A, B | — | — |
| 1A7F | Insulin mutant B16 glu, B24 gly, des-B30, NMR, 20 structures | solution nmr | A, B | — | — |
| 1AI0 | R6 human insulin hexamer (non-symmetric), NMR, 10 structures | solution nmr | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1AI0 | R6 human insulin hexamer (non-symmetric), NMR, 10 structures | solution nmr | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1AIY | R6 human insulin hexamer (symmetric), NMR, 10 structures | solution nmr | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1AIY | R6 human insulin hexamer (symmetric), NMR, 10 structures | solution nmr | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1B9E | Human insulin mutant SERB9GLU | x-ray diffraction | A, B, C, D | — | — |
| 1B9E | Human insulin mutant SERB9GLU | x-ray diffraction | A, B, C, D | — | — |
| 1BEN | Insulin complexed with 4-hydroxybenzamide | x-ray diffraction | A, B, C, D | — | — |
| 1BEN | Insulin complexed with 4-hydroxybenzamide | x-ray diffraction | A, B, C, D | — | — |
| 1EFE | An active mini-proinsulin, M2PI | solution nmr | A | — | — |
| 1EFE | An active mini-proinsulin, M2PI | solution nmr | A | — | — |
| 1EV3 | Structure of the rhombohedral form of the M-cresol/insulin R6 hexamer | x-ray diffraction | A, B, C, D | — | — |
| 1EV3 | Structure of the rhombohedral form of the M-CRESOL/INSULIN R6 hexamer | x-ray diffraction | A, B, C, D | — | — |
| 1EV6 | Structure of the monoclinic form of the M-cresol/insulin R6 hexamer | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1EV6 | Structure of the monoclinic form of the M-CRESOL/INSULIN R6 hexamer | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1EVR | The structure of the resorcinol/insulin R6 hexamer | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1EVR | The structure of the RESORCINOL/INSULIN R6 hexamer | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1FU2 | First protein structure determined from X-ray powder diffraction data | powder diffraction | A, B, C, D, E, F, G, H | — | — |
| 1FU2 | First protein structure determined from X-ray powder diffraction data | powder diffraction | A, B, C, D, E, F, G, H | — | — |
| 1FUB | First protein structure determined from X-ray powder diffraction data | powder diffraction | A, B, C, D | — | — |
| 1FUB | First protein structure determined from X-ray powder diffraction data | powder diffraction | A, B, C, D | — | — |
| 1G7A | 1.2 A structure of T3R3 human insulin at 100 K | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1G7A | 1.2 a structure of T3R3 human insulin at 100 K | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1G7B | 1.3 a structure of T3R3 human insulin at 100 K | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1G7B | 1.3 a structure of T3R3 human insulin at 100 K | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1GUJ | Insulin at pH 2: structural analysis of the conditions promoting insulin fibre formation. | x-ray diffraction | A, B, C, D | — | — |
| 1GUJ | Insulin at pH 2: structural analysis of the conditions promoting insulin fibre formation. | x-ray diffraction | A, B, C, D | — | — |
| 1HIQ | Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus | solution nmr | A, B | — | — |
| 1HIQ | Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus | solution nmr | A, B | — | — |
| 1HIS | Structure and dynamics of des-pentapeptide-insulin in solution: the molten-globule hypothesis. | solution nmr | A, B | — | — |
| 1HIS | Structure and dynamics of des-pentapeptide-insulin in solution: the molten-globule hypothesis. | solution nmr | A, B | — | — |
| 1HIT | Receptor binding redefined by a structural switch in a mutant Human Insulin | solution nmr | A, B | — | — |
| 1HIT | Receptor binding redefined by a structural switch in a mutant human insulin | solution nmr | A, B | — | — |
| 1HLS | NMR structure of the human insulin-HIS(B16) | solution nmr | A, B | — | — |
| 1HLS | NMR structure of the human insulin-HIS(B16) | solution nmr | A, B | — | — |
| 1HTV | Crystal structure of destripeptide (B28-B30) insulin | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1HTV | Crystal structure of destripeptide (B28-B30) insulin | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 1HUI | Insulin mutant (B1, B10, B16, B27)GLU, des-B30, NMR, 25 structures | solution nmr | A, B | — | — |
| 1HUI | Insulin mutant (B1, B10, B16, B27)GLU, des-B30, NMR, 25 structures | solution nmr | A, B | — | — |
| 1IOG | Insulin mutant A3 GLY,(B1, B10, B16, B27)GLU, des-B30, NMR, 19 structures | solution nmr | A, B | — | — |
| 1IOG | Insulin mutant A3 GLY,(B1, B10, B16, B27)GLU, des-B30, NMR, 19 structures | solution nmr | A, B | — | — |
| 1IOH | Insulin mutant A8 HIS,(B1, B10, B16, B27)GLU, des-B30, NMR, 26 structures | solution nmr | A, B | — | — |
| 1IOH | Insulin mutant A8 HIS,(B1, B10, B16, B27)GLU, des-B30, NMR, 26 structures | solution nmr | A, B | — | — |
| 1J73 | Crystal structure of an unstable insulin analog with native activity. | x-ray diffraction | A, B, C, D | — | — |
| 1J73 | Crystal structure of an unstable insulin analog with native activity. | x-ray diffraction | A, B, C, D | — | — |
| 1JCA | Non-standard Design of Unstable Insulin Analogues with Enhanced Activity | x-ray diffraction | A, B, C, D | — | — |
| 1JCA | Non-standard design of unstable insulin analogues with enhanced activity | x-ray diffraction | A, B, C, D | — | — |
| 1JCO | Solution structure of the monomeric [Thr(B27)->Pro,Pro(B28)->Thr] insulin mutant (PT insulin) | solution nmr | A, B | — | — |
| 1JCO | Solution structure of the monomeric [THR(B27)->PRO,PRO(B28)->thr] insulin mutant (pt insulin) | solution nmr | A, B | — | — |
| 1K3M | NMR structure of human insulin mutant ile-A2-ala, his-B10-asp, pro-B28-lys, lys-B29-pro, 15… | solution nmr | A, B | — | — |
| 1K3M | NMR structure of human insulin mutant ile-A2-ala, his-B10-asp, pro- B28-lys, lys-B29-pro, 15… | solution nmr | A, B | — | — |
| 1KMF | NMR structure of human insulin mutant ile-A2-allo-ile, his-B10-asp, pro-B28-lys, lys-B29-pro, 15… | solution nmr | A, B | — | — |
| 1KMF | NMR structure of human insulin mutant ile-A2-allo-ile, his-B10-asp, pro-B28-lys, lys-B29-pro, 15… | solution nmr | A, B | — | — |
| 1LKQ | NMR structure of human insulin mutant ile-A2-gly, val-A3-gly, his-B10-asp, pro-B28-lys… | solution nmr | A, B | — | — |
| 1LKQ | NMR structure of human insulin mutant ile-A2-gly, val-A3-gly, his-B10- asp, pro-B28-lys… | solution nmr | A, B | — | — |
| 1LPH | LYS(B28)PRO(B29)-human insulin | x-ray diffraction | A, B, C, D | — | — |
| 1LPH | LYS(B28)PRO(B29)-human insulin | x-ray diffraction | A, B, C, D | — | — |
| 1MHI | Three-dimensional solution structure of an insulin dimer. a study of the B9(ASP) mutant of human… | solution nmr | A, B | — | — |
| 1MHI | Three-dimensional solution structure of an insulin dimer. a study of the B9(ASP) mutant of human… | solution nmr | A, B | — | — |
514 records more on the page itself.
Ligands
- ZN · Zinc ion · in 32 records
- CL · Chloride ion · in 24 records
- IPH · Phenol · in 16 records
- NA · Sodium ion · in 5 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 5 records
- SRO · Serotonin · in 5 records
- ACN · Acetone · in 3 records
- CRS · M-cresol · in 3 records
- IS8 · isothiocyanate · in 2 records
- KUT · Kut [2-(2-[2-(2-[2-(octadecandioyl-gamma-glu) amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] · in 2 records
- MYR · Myristic acid · in 2 records
- 02A · (2S)-azetidine-2-carboxylic acid · in 1 record
- CO · Cobalt (II) ion · in 1 record
- FUC · alpha-L-fucopyranose · in 1 record
- GD · Gadolinium atom · in 1 record
- HC4 · 4'-hydroxycinnamic acid · in 1 record
- NO3 · Nitrate ion · in 1 record
- PO4 · Phosphate ion · in 1 record
- SCN · Thiocyanate ion · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 7RZF chain b against the predicted model P01308: TM-score 0.70, RMSD 0.21 Å
- 8IPZ chain D against the predicted model P01308: TM-score 0.52, RMSD 0.81 Å
- 1EV3 chain B against the predicted model P01308: TM-score 0.52, RMSD 1.17 Å
- 1EV6 chain B against the predicted model P01308: TM-score 0.51, RMSD 1.15 Å
- 8HGZ chain N against the predicted model P01308: TM-score 0.51, RMSD 1.15 Å
- 5UQA chain J against the predicted model P01308: TM-score 0.51, RMSD 0.88 Å
- 8IPZ chain F against the predicted model P01308: TM-score 0.51, RMSD 1.16 Å
- 8IPZ chain H against the predicted model P01308: TM-score 0.51, RMSD 1.13 Å
- 5UQA chain H against the predicted model P01308: TM-score 0.50, RMSD 0.89 Å
- 5UQA chain D against the predicted model P01308: TM-score 0.50, RMSD 0.89 Å
Elsewhere
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