MolNFT v1 · #187580 · protein
Full-length insulin receptor bound with site 2 binding deficient mutant insulin (a-L13R) -- asymmetric conformation
7SL2: “Full-length insulin receptor bound with site 2 binding deficient mutant insulin (a-L13R) -- asymmetric…”. Electron microscopy, 20 pockets (best druggability 0.76). MolNFT v1 #187580 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7SL2
- Type
- protein
- Length
- 1,796 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin receptor; Insulin B chain; Insulin a chain
- EC
- 2.7.10.1
- UniProt
- P15208, P01308
- Pockets
- 20 · best druggability 0.76
Structure
electron microscopy · 7 distinct chains · 13% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin receptor (EC 2.7.10.1) | protein | 806 | 10% helix, 30% strand | P15208 |
| B | Insulin receptor (EC 2.7.10.1) | protein | 798 | 10% helix, 32% strand | P15208 |
| C | Insulin B chain | protein | 27 | 37% helix, 4% strand | P01308 |
| D | Insulin B chain | protein | 25 | 36% helix, 4% strand | P01308 |
| E | Insulin B chain | protein | 27 | 41% helix, 11% strand | P01308 |
| F | Insulin B chain | protein | 29 | 52% helix, 10% strand | P01308 |
| G, H, I, J | Insulin a chain | protein | 21 | 62% helix, 5% strand | P01308 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 397 | 0.76 | 0.86 | 32 | empty |
| 2 | 176 | 0.65 | 0.85 | 34 | empty |
| 3 | 175 | 0.63 | 0.84 | 30 | empty |
| 4 | 410 | 0.62 | 0.77 | 37 | empty |
| 5 | 476 | 0.62 | 0.76 | 47 | empty |
Interfaces
25 interfaces between chains.
- A–B · 2173 Ų buried · 11 hydrogen bonds · protein-protein
- F–J · 796 Ų buried · 8 hydrogen bonds · protein-protein
- C–G · 743 Ų buried · 9 hydrogen bonds · protein-protein
- B–H · 719 Ų buried · 10 hydrogen bonds · protein-protein
- E–I · 692 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 45 disulfide (disulfide).
Compared structures
- 7SL2 · Full-length insulin receptor bound with site 2 binding deficient mutant insulin (A-L13R)… · the same entry in another collection · chain J against J, TM-score 1.00
- P15208 · AlphaFold monomer V2.0 prediction for insulin receptor (P15208) · a predicted model of the same protein · chain A against A, TM-score 0.66
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15208
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 7SL2 · PDBe 7SL2 · UniProt P15208 · UniProt P01308
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.