MolNFT v1 · #187585 · protein
Full-length insulin receptor bound with both site 1 binding deficient mutant insulin (a-V3E) and site 2 binding deficient mutant insulin (a-L13R)
7SL7: “Full-length insulin receptor bound with both site 1 binding deficient mutant insulin (a-V3E) and site 2…”. Electron microscopy, 18 pockets (best druggability 0.77). MolNFT v1 #187585 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7SL7
- Type
- protein
- Length
- 1,826 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin receptor; Insulin B chain; Insulin a chain (L13R); Insulin a chain (V3E)
- EC
- 2.7.10.1
- UniProt
- P15208, P01308
- Pockets
- 18 · best druggability 0.77
Structure
electron microscopy · 5 distinct chains · 16% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Insulin receptor (EC 2.7.10.1) | protein | 819 | 13% helix, 31% strand | P15208 |
| G, H | Insulin B chain | protein | 27 | 37% helix, 4% strand | P01308 |
| I, J | Insulin B chain | protein | 25 | 40% helix, 0% strand | P01308 |
| C, D | Insulin a chain (L13R) | protein | 21 | 57% helix, 5% strand | P01308 |
| E, F | Insulin a chain (V3E) | protein | 21 | 43% helix, 0% strand | P01308 |
Pockets
18 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1198 | 0.77 | 0.79 | 101 | empty |
| 2 | 1179 | 0.77 | 0.79 | 95 | empty |
| 3 | 405 | 0.66 | 0.79 | 42 | empty |
| 4 | 523 | 0.65 | 0.77 | 40 | empty |
| 5 | 247 | 0.56 | 0.78 | 27 | empty |
Interfaces
19 interfaces between chains.
- A–B · 2840 Ų buried · 27 hydrogen bonds · protein-protein
- H–D · 664 Ų buried · 9 hydrogen bonds · protein-protein
- G–C · 660 Ų buried · 9 hydrogen bonds · protein-protein
- I–E · 606 Ų buried · 6 hydrogen bonds · protein-protein
- J–F · 604 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 46 disulfide (disulfide).
Compared structures
- 7SL7 · Full-length insulin receptor bound with both site 1 binding deficient mutant insulin… · the same entry in another collection · chain F against F, TM-score 1.00
- P15208 · AlphaFold monomer V2.0 prediction for insulin receptor (P15208) · a predicted model of the same protein · chain A against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15208
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 7SL7 · PDBe 7SL7 · UniProt P15208 · UniProt P01308
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