MolNFT v1 · #187582 · protein
Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R) -- asymmetric conformation
7SL4: “Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R) -- asymmetric…”. Electron microscopy, 19 pockets (best druggability 0.84). MolNFT v1 #187582 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7SL4
- Type
- protein
- Length
- 1,673 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin receptor; Insulin B chain; Insulin a chain
- EC
- 2.7.10.1
- UniProt
- P15208, P01308
- Pockets
- 19 · best druggability 0.84
Structure
electron microscopy · 5 distinct chains · 12% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin receptor (EC 2.7.10.1) | protein | 786 | 10% helix, 32% strand | P15208 |
| B | Insulin receptor (EC 2.7.10.1) | protein | 797 | 11% helix, 28% strand | P15208 |
| C | Insulin B chain | protein | 27 | 37% helix, 4% strand | P01308 |
| D | Insulin B chain | protein | 21 | 43% helix, 0% strand | P01308 |
| E, F | Insulin a chain | protein | 21 | 57% helix, 5% strand | P01308 |
Pockets
19 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 259 | 0.84 | 0.95 | 48 | empty |
| 2 | 266 | 0.81 | 0.91 | 37 | empty |
| 3 | 129 | 0.79 | 0.96 | 27 | empty |
| 4 | 880 | 0.78 | 0.81 | 109 | empty |
| 5 | 487 | 0.74 | 0.82 | 38 | empty |
Interfaces
11 interfaces between chains.
- A–B · 1932 Ų buried · 13 hydrogen bonds · protein-protein
- C–E · 639 Ų buried · 11 hydrogen bonds · protein-protein
- B–F · 534 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 508 Ų buried · 3 hydrogen bonds · protein-protein
- D–F · 476 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 38 disulfide (disulfide).
Compared structures
- 7SL4 · Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R)… · the same entry in another collection · chain F against F, TM-score 1.00
- P15208 · AlphaFold monomer V2.0 prediction for insulin receptor (P15208) · a predicted model of the same protein · chain A against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15208
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 7SL4 · PDBe 7SL4 · UniProt P15208 · UniProt P01308
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