MolNFT v1 · #187579 · protein
Full-length insulin receptor bound with site 1 binding deficient mutant insulin (a-V3E)
7SL1: “Full-length insulin receptor bound with site 1 binding deficient mutant insulin (a-V3E)”. Electron microscopy, 20 pockets (best druggability 0.73). MolNFT v1 #187579 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7SL1
- Type
- protein
- Length
- 1,714 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin receptor; Insulin B chain; Insulin a chain
- EC
- 2.7.10.1
- UniProt
- P15208, P01308
- Pockets
- 20 · best druggability 0.73
Structure
electron microscopy · 3 distinct chains · 11% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Insulin receptor (EC 2.7.10.1) | protein | 813 | 10% helix, 32% strand | P15208 |
| C, D | Insulin B chain | protein | 23 | 43% helix, 0% strand | P01308 |
| E, F | Insulin a chain | protein | 21 | 43% helix, 0% strand | P01308 |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 776 | 0.73 | 0.78 | 58 | empty |
| 2 | 819 | 0.72 | 0.78 | 99 | empty |
| 3 | 768 | 0.72 | 0.78 | 63 | empty |
| 4 | 737 | 0.72 | 0.78 | 90 | empty |
| 5 | 336 | 0.68 | 0.82 | 32 | empty |
Interfaces
11 interfaces between chains.
- A–B · 4458 Ų buried · 61 hydrogen bonds · protein-protein
- D–F · 650 Ų buried · 9 hydrogen bonds · protein-protein
- C–E · 649 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 530 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 530 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 42 disulfide (disulfide).
Compared structures
- 7SL1 · Full-length insulin receptor bound with site 1 binding deficient mutant insulin (A-V3E) · the same entry in another collection · chain C against C, TM-score 1.00
- P15208 · AlphaFold monomer V2.0 prediction for insulin receptor (P15208) · a predicted model of the same protein · chain A against A, TM-score 0.61
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15208
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 7SL1 · PDBe 7SL1 · UniProt P15208 · UniProt P01308
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