UniProt P0A8V2
DNA-directed RNA polymerase subunit beta (P0A8V2)
DNA-directed RNA polymerase subunit beta (UniProt P0A8V2), EC 2.7.7.6: 142 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 456 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P0A8V2
- Protein
- DNA-directed RNA polymerase subunit beta
- EC
- 2.7.7.6
- Experimental structures
- 142
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 456 · 32 records with a druggable one
Structures
143 records of P0A8V2 in the MolNFT archive: 142 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3IYD | Three-dimensional EM structure of an intact activator-dependent transcription initiation complex | electron microscopy | C | — | — |
| 3IYD | Three-dimensional EM structure of an intact activator-dependent transcription initiation complex | electron microscopy | C | — | — |
| 3LTI | Crystal structure of the Escherichia coli RNA polymerase beta subunit beta2-betai4 domains | x-ray diffraction | A | — | — |
| 3LTI | Crystal structure of the escherichia COLI RNA polymerase beta subunit BETA2-BETAI4 domains | x-ray diffraction | A | — | — |
| 3LU0 | Molecular model of Escherichia coli core RNA polymerase | electron microscopy | C | — | — |
| 3LU0 | Molecular model of escherichia COLI core RNA polymerase | electron microscopy | C | — | — |
| 3TBI | Crystal structure of T4 gp33 bound to E. coli RNAP beta-flap domain | x-ray diffraction | B | — | — |
| 3TBI | Crystal structure of T4 GP33 bound to E. COLI rnap beta-flap domain | x-ray diffraction | B | — | — |
| 4JK1 | X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with Guanosine… | x-ray diffraction | C, H | — | — |
| 4JK1 | X-ray crystal structure of escherichia COLI SIGMA70 holoenzyme in complex with guanosine… | x-ray diffraction | C, H | — | — |
| 4JK2 | X-ray crystal structure of Escherichia coli sigma70 holoenzyme in complex with guanosine… | x-ray diffraction | C, H | — | — |
| 4JK2 | X-ray crystal structure of escherichia COLI SIGMA70 holoenzyme in complex with guanosine… | x-ray diffraction | C, H | — | — |
| 4KMU | X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Rifampin | x-ray diffraction | C, H | — | — |
| 4KMU | X-ray crystal structure of the escherichia COLI RNA polymerase in complex with rifampin | x-ray diffraction | C, H | — | — |
| 4KN4 | X-ray crystal structure of the Escherichia coli RNA polymerase in complex with… | x-ray diffraction | C, H | — | — |
| 4KN4 | X-ray crystal structure of the escherichia COLI RNA polymerase in complex with… | x-ray diffraction | C, H | — | — |
| 4KN7 | X-ray crystal structure of the Escherichia coli RNA polymerase in complex with… | x-ray diffraction | C, H | — | — |
| 4KN7 | X-ray crystal structure of the escherichia COLI RNA polymerase in complex with… | x-ray diffraction | C, H | — | — |
| 4MEX | Crystal structure of Escherichia coli RNA polymerase in complex with salinamide A | x-ray diffraction | C, I | — | — |
| 4MEX | Crystal structure of escherichia COLI RNA polymerase in complex with salinamide a | x-ray diffraction | C, I | — | — |
| 4MEY | Crystal structure of Escherichia coli RNA polymerase holoenzyme | x-ray diffraction | C, I | — | — |
| 4MEY | Crystal structure of escherichia COLI RNA polymerase holoenzyme | x-ray diffraction | C, I | — | — |
| 4ZH2 | Crystal structure of escherichia COLI RNA polymerase in complex with CBR703 | x-ray diffraction | C, I | — | — |
| 4ZH3 | Crystal structure of Escherichia coli RNA polymerase in complex with CBRH16-Br | x-ray diffraction | C, I | 4OD | 17 (best 0.84) |
| 4ZH3 | Crystal structure of escherichia COLI RNA polymerase in complex with CBRH16-br | x-ray diffraction | C, I | — | — |
| 4ZH4 | Crystal structure of Escherichia coli RNA polymerase in complex with CBRP18 | x-ray diffraction | C, I | 4OE | 18 (best 0.84) |
| 4ZH4 | Crystal structure of escherichia COLI RNA polymerase in complex with CBRP18 | x-ray diffraction | C, I | — | — |
| 5BYH | Crystal structure of escherichia COLI RNA polymerase - SIGMA54 holoenzyme complex | x-ray diffraction | C | — | — |
| 5IPL | SigmaS-transcription initiation complex with 4-nt nascent RNA | x-ray diffraction | C | DPO, MG | — |
| 5IPL | Sigmas-transcription initiation complex with 4-nt nascent RNA | x-ray diffraction | C | — | — |
| 5IPM | SigmaS-transcription initiation complex with 4-nt nascent RNA | x-ray diffraction | C | — | — |
| 5IPM | Sigmas-transcription initiation complex with 4-nt nascent RNA | x-ray diffraction | C | — | — |
| 5IPN | Sigmas-transcription initiation complex with 4-nt nascent RNA | x-ray diffraction | C | — | — |
| 5MS0 | pseudo-atomic model of the RNA polymerase lambda-based antitermination complex solved by cryo-EM | electron microscopy | C | — | — |
| 5MS0 | Pseudo-atomic model of the RNA polymerase lambda-based antitermination complex solved by cryo-EM | electron microscopy | C | — | — |
| 5NSR | Cryo-EM structure of RNA polymerase-SIGMA54 holo enzyme with promoter DNA closed complex | electron microscopy | C | — | — |
| 5NSS | Cryo-EM structure of RNA polymerase-SIGMA54 holoenzyme with promoter DNA and transcription… | electron microscopy | C | — | — |
| 5NWT | Crystal Structure of Escherichia coli RNA polymerase - Sigma54 Holoenzyme complex | x-ray diffraction | C | — | 15 (best 0.88) |
| 5NWT | Crystal structure of escherichia COLI RNA polymerase - SIGMA54 holoenzyme complex | x-ray diffraction | C | — | — |
| 5UAC | Escherichia coli RNA polymerase and Rifampin complex, wild-type | x-ray diffraction | C, I | RFP | — |
| 5UAC | Escherichia COLI RNA polymerase and rifampin complex, wild-type | x-ray diffraction | C, I | RFP | — |
| 5UAG | Escherichia coli RNA polymerase mutant - RpoB D516V | x-ray diffraction | C, I | MG | — |
| 5UAG | Escherichia COLI RNA polymerase mutant - rpob D516V | x-ray diffraction | C, I | MG | — |
| 5UAH | Escherichia coli RNA polymerase and Rifampin complex, RpoB D516V mutant | x-ray diffraction | C, I | RFP, MG | — |
| 5UAH | Escherichia COLI RNA polymerase and rifampin complex, rpob D516V mutant | x-ray diffraction | C, I | RFP, MG | — |
| 5UAJ | Escherichia COLI RNA polymerase rpob S531L mutant | x-ray diffraction | C, I | — | — |
| 5UAL | Escherichia COLI RNA polymerase and rifampin complex, rpob S531L mutant | x-ray diffraction | C, I | RFP | — |
| 5UAQ | Escherichia COLI RNA polymerase rpob H526Y mutant | x-ray diffraction | C, I | — | — |
| 5VSW | X-ray crystal structure of escherichia COLI RNA polymerase and DKSA/PPGPP complex | x-ray diffraction | C, I | — | — |
| 5VT0 | Escherichia COLI 6S RNA derivative in complex with escherichia COLI RNA polymerase… | electron microscopy | I | — | — |
| 5W1S | X-ray crystal structure of escherichia COLI RNA polymerase and trar complex | x-ray diffraction | C, I | — | — |
| 5W1T | X-ray crystal structure of escherichia COLI RNA polymerase and dksa complex | x-ray diffraction | C, I | — | — |
| 6ALF | Cryoem structure of crosslinked E.COLI RNA polymerase elongation complex | electron microscopy | I | — | — |
| 6ALG | CryoEM structure of HK022 Nun - E.coli RNA polymerase elongation complex | electron microscopy | I | — | — |
| 6ALG | Cryoem structure of HK022 nun - E.COLI RNA polymerase elongation complex | electron microscopy | I | — | — |
| 6ALH | Cryoem structure of E.COLI RNA polymerase elongation complex | electron microscopy | I | — | — |
| 6ASX | Cryoem structure of E.COLI his pause elongation complex | electron microscopy | I | — | — |
| 6BJS | CryoEM structure of E.coli his pause elongation complex without pause hairpin | electron microscopy | I | — | — |
| 6BJS | Cryoem structure of E.COLI his pause elongation complex without pause hairpin | electron microscopy | I | — | — |
| 6BYU | X-ray crystal structure of escherichia COLI RNA polymerase (rpob- H526Y) and ppapp complex | x-ray diffraction | C, I | ECJ | — |
83 records more on the page itself.
Ligands
- 1N7 · Chapso · in 7 records
- RFP · Rifampicin · in 7 records
- MG · Magnesium ion · in 6 records
- DPO · Diphosphate · in 2 records
- KNG · Kanglemycin A · in 2 records
- 4OD · N'-(3-bromophenyl)-4-fluoro-N-hydroxy-3-(trifluoromethyl)benzenecarboximidamide · in 1 record
- 4OE · 5-(4-fluorophenyl)-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-pyrazole · in 1 record
- CTP · Cytidine-5'-triphosphate · in 1 record
- D9X · (2s,7r,7ar,13ap,16z,18e,20s,21s,22r,23r,24r,25s,26r, 27S,28E)-5,21,23-trihydroxy-27-methoxy-2,4,16,20,22, 24,26-heptamethyl-10-[4-(2-methylpropyl)piperazin-1-yl]-12-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1, 6,15-trioxo-1,2,7,7A-tetrahydro-6H-2,7-(epoxypentadeca[1,11,13]trienoimino)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate · in 1 record
- ECJ · (5R)-5-(6-amino-9H-purin-9-yl)-2-({[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}methyl)-4-oxo-4,5-dihydrofuran-3-yl trihydrogen diphosphate · in 1 record
- POP · Pyrophosphate 2- · in 1 record
Experiment against prediction
- 8FVR chain F against the predicted model P0A8V2: TM-score 0.99, RMSD 1.06 Å
- 6ALF chain I against the predicted model P0A8V2: TM-score 0.99, RMSD 1.06 Å
- 6ALG chain I against the predicted model P0A8V2: TM-score 0.99, RMSD 1.08 Å
- 6ALG chain I against the predicted model P0A8V2: TM-score 0.99, RMSD 1.08 Å
- 8FVW chain F against the predicted model P0A8V2: TM-score 0.99, RMSD 1.09 Å
- 6ALH chain I against the predicted model P0A8V2: TM-score 0.99, RMSD 1.13 Å
- 6C6T chain I against the predicted model P0A8V2: TM-score 0.99, RMSD 1.15 Å
- 6RI7 chain C against the predicted model P0A8V2: TM-score 0.99, RMSD 1.18 Å
- 6C6U chain I against the predicted model P0A8V2: TM-score 0.99, RMSD 1.18 Å
- 8UR0 chain AA against the predicted model P0A8V2: TM-score 0.99, RMSD 1.18 Å
Elsewhere
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