UniProt P09038
Fibroblast growth factor 2 (P09038)
Fibroblast growth factor 2 (UniProt P09038): 45 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P09038
- Protein
- Fibroblast growth factor 2
- Experimental structures
- 45
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 3 · 1 record with a druggable one
Structures
46 records of P09038 in the MolNFT archive: 45 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BAS | Three-dimensional structures of acidic and basic fibroblast growth factors | x-ray diffraction | A | — | — |
| 1BAS | Three-dimensional structures of acidic and basic fibroblast growth factors | x-ray diffraction | A | — | — |
| 1BFB | Basic fibroblast growth factor complexed with heparin tetramer fragment | x-ray diffraction | A | — | — |
| 1BFB | Basic fibroblast growth factor complexed with heparin tetramer fragment | x-ray diffraction | A | — | — |
| 1BFC | Basic fibroblast growth factor complexed with heparin hexamer fragment | x-ray diffraction | A | — | — |
| 1BFC | Basic fibroblast growth factor complexed with heparin hexamer fragment | x-ray diffraction | A | — | — |
| 1BFF | The 154 amino acid form of human basic fibroblast growth factor | x-ray diffraction | A | — | — |
| 1BFF | The 154 amino acid form of human basic fibroblast growth factor | x-ray diffraction | A | — | — |
| 1BFG | Crystal structure of basic fibroblast growth factor at 1.6 ångströms resolution | x-ray diffraction | A | — | — |
| 1BFG | Crystal structure of basic fibroblast growth factor at 1.6 ångströms resolution | x-ray diffraction | A | — | — |
| 1BLA | Basic fibroblast growth factor (FGF-2) mutant with cys 78 replaced by ser and cys 96 replaced by… | solution nmr | A | — | — |
| 1BLA | Basic fibroblast growth factor (FGF-2) mutant with cys 78 replaced by ser and cys 96 replaced by… | solution nmr | A | — | — |
| 1BLD | Basic fibroblast growth factor (FGF-2) mutant with cys 78 replaced by ser and cys 96 replaced by… | solution nmr | A | — | — |
| 1BLD | Basic fibroblast growth factor (FGF-2) mutant with cys 78 replaced by ser and cys 96 replaced by… | solution nmr | A | — | — |
| 1CVS | Crystal structure of a dimeric FGF2-FGFR1 complex | x-ray diffraction | A, B | — | — |
| 1CVS | Crystal structure of a dimeric FGF2-FGFR1 complex | x-ray diffraction | A, B | — | — |
| 1EV2 | Crystal structure of FGF2 in complex with the extracellular ligand binding domain of FGF receptor 2… | x-ray diffraction | A, B, C, D | — | — |
| 1EV2 | Crystal structure of FGF2 in complex with the extracellular ligand binding domain of FGF receptor 2… | x-ray diffraction | A, B, C, D | — | — |
| 1FGA | Refinement of the structure of human basic fibroblast growth factor at 1.6 ångströms resolution and… | x-ray diffraction | A | — | — |
| 1FGA | Refinement of the structure of human basic fibroblast growth factor at 1.6 ångströms resolution and… | x-ray diffraction | A | — | — |
| 1FQ9 | Crystal structure of a ternary FGF2-FGFR1-heparin complex | x-ray diffraction | A, B | — | — |
| 1FQ9 | Crystal structure of a ternary FGF2-FGFR1-heparin complex | x-ray diffraction | A, B | — | — |
| 1II4 | Crystal structure of SER252TRP apert mutant FGF receptor 2 (FGFR2) in complex with FGF2 | x-ray diffraction | A, B, C, D | — | — |
| 1II4 | Crystal structure of SER252TRP apert mutant FGF receptor 2 (FGFR2) in complex with FGF2 | x-ray diffraction | A, B, C, D | — | — |
| 1IIL | Crystal structure of PRO253ARG apert mutant FGF receptor 2 (FGFR2) in complex with FGF2 | x-ray diffraction | A, B, C, D | — | — |
| 1IIL | Crystal structure of PRO253ARG apert mutant FGF receptor 2 (FGFR2) in complex with FGF2 | x-ray diffraction | A, B, C, D | — | — |
| 2BFH | Crystal structure of basic fibroblast growth factor at 1.6 ångströms resolution | x-ray diffraction | A | — | — |
| 2BFH | Crystal structure of basic fibroblast growth factor at 1.6 ångströms resolution | x-ray diffraction | A | — | — |
| 2FGF | Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of… | x-ray diffraction | A | — | — |
| 2FGF | Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of… | x-ray diffraction | A | — | — |
| 2M49 | Structural Insights into Human S100B and Basic Fibroblast Growth Factor (FGF2) Interaction | solution nmr | A, C | — | — |
| 2M49 | Structural insights into human S100B and basic fibroblast growth factor (FGF2) interaction | solution nmr | A, C | — | — |
| 4FGF | Refinement of the structure of human basic fibroblast growth factor at 1.6 ångströms resolution and… | x-ray diffraction | A | — | — |
| 4FGF | Refinement of the structure of human basic fibroblast growth factor at 1.6 ångströms resolution and… | x-ray diffraction | A | — | — |
| 4OEE | Crystal Structure Analysis of FGF2-Disaccharide (S3I2) complex | x-ray diffraction | A | — | — |
| 4OEE | Crystal structure analysis of FGF2-disaccharide (S3I2) complex | x-ray diffraction | A | — | — |
| 4OEF | Crystal Structure Analysis of FGF2-Disaccharide (S6I2) complex | x-ray diffraction | A | — | — |
| 4OEF | Crystal structure analysis of FGF2-disaccharide (S6I2) complex | x-ray diffraction | A | — | — |
| 4OEG | Crystal Structure Analysis of FGF2-Disaccharide (S9I2) complex | x-ray diffraction | A | — | — |
| 4OEG | Crystal structure analysis of FGF2-disaccharide (S9I2) complex | x-ray diffraction | A | — | — |
| 5X1O | PI(4,5)P2 lipid binding induced a reorientation of FGF2 molecules near membrane surface to… | x-ray diffraction | A, B | I3P | — |
| 6L4O | Crystal structure of API5-FGF2 complex | x-ray diffraction | B | — | — |
| 8HU7 | Crystal structure of FGF2-M1 mutant - D28E/C78L/C96I/S137P | x-ray diffraction | A | — | — |
| 8HUE | Crystal structure of FGF2-M2 mutant - D28E/C78I/C96I/S137P | x-ray diffraction | A, B, C | GU4, YYJ | 3 (best 0.59) |
| 8OM6 | Crystal structure of FGF2-STAB, a stable variant of human fibroblast growth factor 2 | x-ray diffraction | A | — | — |
| P09038 | AlphaFold monomer V2.0 prediction for fibroblast growth factor 2 (P09038) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1BFG chain A against the predicted model P09038: TM-score 0.99, RMSD 0.30 Å
- 1BFG chain A against the predicted model P09038: TM-score 0.99, RMSD 0.30 Å
- 1BAS chain A against the predicted model P09038: TM-score 0.99, RMSD 0.32 Å
- 1BAS chain A against the predicted model P09038: TM-score 0.99, RMSD 0.32 Å
- 4OEF chain A against the predicted model P09038: TM-score 0.99, RMSD 0.35 Å
- 4OEF chain A against the predicted model P09038: TM-score 0.99, RMSD 0.35 Å
- 4OEG chain A against the predicted model P09038: TM-score 0.99, RMSD 0.37 Å
- 4OEG chain A against the predicted model P09038: TM-score 0.99, RMSD 0.37 Å
- 4FGF chain A against the predicted model P09038: TM-score 0.99, RMSD 0.37 Å
- 4FGF chain A against the predicted model P09038: TM-score 0.99, RMSD 0.37 Å
Elsewhere
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