Ligand · IDU

IDU · 2-O-sulfo-beta-L-altropyranuronic acid

IDU, 2-O-sulfo-beta-L-altropyranuronic acid (C6 H10 O10 S, 274.2 g/mol), in the MolNFT structures on GenesisL1: bound in 10 records (7 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…

Component: IDU
Formula: C6 H10 O10 S
Class: sugar
Structures: 10
PDB entries: 7

Binding sites

IDU in 10 structures; the first of them:

1FQ9 · Crystal structure of a ternary FGF2-FGFR1-heparin complex · IDU E2 · binds LYS129
2BRS · EMBP Heparin complex · IDU C2 · binds ARG103, ARG109
2WNU · Complex between c1q globular heads and heparan sulfate · IDU G2 · binds LEU109, LYS129, GLY158, TRP190
8XUR · BA.2.86 Spike Trimer in complex with heparan sulfate · IDU C1313 · binds THR167, PHE168
8XUS · JN.1 Spike Trimer in complex with heparan sulfate · IDU B1317 · binds ARG355, THR356, ARG357, THR167, PHE168, GLU169
8XUT · XBB.1.5 Spike Trimer in complex with heparan sulfate · IDU A1317 · binds ARG355, ARG466, GLN115, ILE231, GLY232
8XUU · BA.2.86-T356K Spike Trimer in complex with heparan sulfate (Local refinement) · IDU A1306 · binds PHE168, TYR170, ARG355, LYS356, ARG357, SER359, TYR396
1FQ9 · Crystal structure of a ternary FGF2-FGFR1-heparin complex · IDU E2 · binds LYS129
2BRS · Embp heparin complex · IDU C2 · binds ARG103, ARG109
2WNU · Complex between C1Q globular heads and heparan sulfate · IDU G2 · binds LEU109, LYS129, GLY158, TRP190

Residues it binds most

ARG 5, LYS 5, GLY 3, PHE 3, THR 2, LEU 2, TRP 2, TYR 1, GLN 1, GLU 1 (residue and the binding sites it lines).

Found with

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
SGN · 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose
BMA · beta-D-mannopyranose
IDS · 2-O-sulfo-alpha-L-idopyranuronic acid
UAP · 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid
SO4 · Sulfate ion

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