UniProt P07814
Bifunctional glutamate/proline--tRNA ligase (P07814)
Bifunctional glutamate/proline--tRNA ligase (UniProt P07814), EC 6.1.1.15, 6.1.1.17: 51 experimental structures and 1 predicted model on GenesisL1, 26 ligands bound, 167 pockets. Binding sites, druggability and experiment against…
- UniProt
- P07814
- Protein
- Bifunctional glutamate/proline--tRNA ligase
- EC
- 6.1.1.15, 6.1.1.17
- Experimental structures
- 51
- Predicted models
- 1
- Ligands
- 26
- Pockets
- 167 · 19 records with a druggable one
Structures
52 records of P07814 in the MolNFT archive: 51 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FYJ | Solution structure of multi-functional peptide motif-1 present in human glutamyl-prolyl tRNA… | solution nmr | A | — | — |
| 1FYJ | Solution structure of multi-functional peptide motif-1 present in human glutamyl-prolyl tRNA… | solution nmr | A | — | — |
| 4HVC | Crystal structure of human prolyl-tRNA synthetase in complex with halofugi and ATP analogue | x-ray diffraction | A, B | — | — |
| 4HVC | Crystal structure of human prolyl-tRNA synthetase in complex with halofuginone and ATP analogue | x-ray diffraction | A, B | — | — |
| 4K86 | Crystal structure of human prolyl-tRNA synthetase (apo form) | x-ray diffraction | A | — | — |
| 4K86 | Crystal structure of human prolyl-tRNA synthetase (apo form) | x-ray diffraction | A | — | — |
| 4K87 | Crystal structure of human prolyl-tRNA synthetase (substrate bound form) | x-ray diffraction | A | — | — |
| 4K87 | Crystal structure of human prolyl-tRNA synthetase (substrate bound form) | x-ray diffraction | A | — | — |
| 4K88 | Crystal structure of human prolyl-tRNA synthetase (halofugi bound form) | x-ray diffraction | A | — | — |
| 4K88 | Crystal structure of human prolyl-tRNA synthetase (halofuginone bound form) | x-ray diffraction | A | — | — |
| 5A1N | The crystal structure of the GST-like domains complex of EPRS-AIMP2 mutant S156D | x-ray diffraction | A | — | — |
| 5A1N | The crystal structure of the GST-like domains complex of eprs-AIMP2 mutant S156D | x-ray diffraction | A | — | — |
| 5A34 | The crystal structure of the GST-like domains complex of eprs-AIMP2 | x-ray diffraction | A, C, E, G | — | — |
| 5A5H | The crystal structure of the GST-like domains complex of EPRS C92SC105SC123S mutant-AIMP2 | x-ray diffraction | A, C, E, G | — | — |
| 5A5H | The crystal structure of the GST-like domains complex of eprs C92SC105SC123S mutant-AIMP2 | x-ray diffraction | A, C, E, G | — | — |
| 5BMU | The crystal structure of the GST-like domains complex of AIMP3-EPRS mutant C92SC105SC123S | x-ray diffraction | B, D, F, H | — | — |
| 5BMU | The crystal structure of the GST-like domains complex of AIMP3-eprs mutant C92SC105SC123S | x-ray diffraction | B, D, F, H | — | — |
| 5V58 | Crystal structure of human prolyl-tRNA synthetase in complex with Aze-SA | x-ray diffraction | A | 8X1, ZN | 3 (best 0.70) |
| 5V58 | Crystal structure of human prolyl-tRNA synthetase in complex with aze- sa | x-ray diffraction | A | ZN | — |
| 5VAD | Crystal structure of human Prolyl-tRNA synthetase (PRS) in complex with inhibitor | x-ray diffraction | A, B | 91Y, PRO, ZN | 9 (best 0.77) |
| 5VAD | Crystal structure of human prolyl-tRNA synthetase (prs) in complex with inhibitor | x-ray diffraction | A, B | 91Y, ZN | — |
| 5Y6L | A subcomplex crystal structure of human cytosolic aspartyl-tRNA synthetase and heterotetrameric… | x-ray diffraction | C | PO4 | — |
| 5Y6L | A subcomplex crystal structure of human cytosolic aspartyl-tRNA synthetase and heterotetrameric… | x-ray diffraction | C | PO4 | — |
| 6IY6 | Crystal structure of human cytosolic aspartyl-tRNA synthetase (DRS) in complex with glutathion-S… | x-ray diffraction | E, F, K, L | — | — |
| 6IY6 | Crystal structure of human cytosolic aspartyl-tRNA synthetase (drs) in complex with glutathion-S… | x-ray diffraction | E, F, K, L | — | — |
| 7BBU | Crystal Structure of human Prolyl-tRNA synthetase in complex with NCP26 and L-Proline | x-ray diffraction | A | PRO, MU5, NO3, ZN, CL | 4 (best 0.72) |
| 7BBU | Crystal structure of human prolyl-tRNA synthetase in complex with NCP26 and L-proline | x-ray diffraction | A | MU5, NO3, ZN | — |
| 7F98 | Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L95 | x-ray diffraction | A, B | JE6, ZN, CA, PRO, CL | 10 (best 0.75) |
| 7F99 | Homo sapiens prolyl-tRNA synthetase (hsprs) in complex with L-proline and compound L96 | x-ray diffraction | A, B | 1UI, ZN, CA, CL | — |
| 7F9A | Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L97 | x-ray diffraction | A, B | 1XK, ZN, CA, CL, PRO | 8 (best 0.75) |
| 7F9C | Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L96 | x-ray diffraction | A, B | 1UI, ZN, CA, CL, PRO | 12 (best 0.76) |
| 7F9C | Homo sapiens prolyl-tRNA synthetase (hsprs) in complex with L-proline and compound L96 | x-ray diffraction | A, B | 1UI, ZN, CA, CL | — |
| 7F9D | Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L96 | x-ray diffraction | A, B | 1UI, ZN, CA, CL, PRO | 9 (best 0.74) |
| 7OSY | Human Prolyl-tRNA Synthetase in Complex with L-proline | x-ray diffraction | A, B | PRO, ZN, SR | 10 (best 0.74) |
| 7OSY | Human prolyl-tRNA synthetase in complex with L-proline | x-ray diffraction | A, B | ZN, SR | — |
| 7OSZ | Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 4d | x-ray diffraction | A, B | PRO, 0X7, ZN, SR | 11 (best 0.76) |
| 7OSZ | Human prolyl-tRNA synthetase in complex with L-proline and compound 4D | x-ray diffraction | A, B | 0X7, ZN, SR | — |
| 7OT0 | Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 4h | x-ray diffraction | A, B | PRO, 0YI, ZN, SR | 11 (best 0.76) |
| 7OT0 | Human prolyl-tRNA synthetase in complex with L-proline and compound 4H | x-ray diffraction | A, B | 0YI, ZN, SR | — |
| 7OT1 | Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 3c | x-ray diffraction | A, B | PRO, 1AI, ZN, SR | 7 (best 0.74) |
| 7OT1 | Human prolyl-tRNA synthetase in complex with L-proline and compound 3C | x-ray diffraction | A, B | 1AI, ZN, SR | — |
| 7OT2 | Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 4j | x-ray diffraction | A, B | PRO, 1FI, ZN, SR | 7 (best 0.75) |
| 7OT2 | Human prolyl-tRNA synthetase in complex with L-proline and compound 4J | x-ray diffraction | A, B | 1FI, ZN, SR | — |
| 7OT3 | Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 3b | x-ray diffraction | A, B | PRO, 0W4, ZN, SR | 9 (best 0.74) |
| 7OT3 | Human prolyl-tRNA synthetase in complex with L-proline and compound 3B | x-ray diffraction | A, B | 0W4, ZN, SR | — |
| 7X09 | Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with inhibitors L95 and Halofugi | x-ray diffraction | A, B | HFG, JE6, ZN, BR, CA, CL | 9 (best 0.76) |
| 7X1O | Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with double inhibitors HF and L95 | x-ray diffraction | A, B | HFG, JE6, ZN, BR, CA | 7 (best 0.77) |
| 7Y1H | Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1 | x-ray diffraction | A, B | F99, ATP, ZN, MG | 9 (best 0.79) |
| 7Y1W | Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1 | x-ray diffraction | A, B | ZN, F9O, ATP, MG | — |
| 7Y28 | Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1 | x-ray diffraction | A, B | F96, ATP, ZN, MG | 13 (best 0.80) |
| 7Y3S | Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1 | x-ray diffraction | A, B | F9C, ATP, MG, ZN | 9 (best 0.79) |
| P07814 | AlphaFold monomer V2.0 prediction for bifunctional GLUTAMATE/PROLINE --tRNA ligase (P07814) | predicted | A | — | 10 (best 0.76) |
Ligands
- ZN · Zinc ion · in 30 records
- PRO · Proline · in 12 records
- SR · Strontium ion · in 12 records
- CA · Calcium ion · in 8 records
- CL · Chloride ion · in 8 records
- 1UI · 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide · in 4 records
- ATP · Adenosine-5'-triphosphate · in 4 records
- MG · Magnesium ion · in 4 records
- JE6 · ~{N}-[4-[(3~{S})-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-6-methyl-pyridin-2-yl]-2-phenyl-ethanamide · in 3 records
- 0W4 · ~{N}-[(2-chlorophenyl)methyl]-3-[(2-chlorophenyl) methylamino]pyrazine-2-carboxamide · in 2 records
- 0X7 · 3-[(2-methylphenyl)methylamino]pyrazine-2-carboxamide · in 2 records
- 0YI · 3-[(2-chlorophenyl)methylamino]pyrazine-2-carboxamide · in 2 records
- 1AI · ~{N}-[(2-methylphenyl)methyl]-3-[(2-methylphenyl) methylamino]pyrazine-2-carboxamide · in 2 records
- 1FI · 3-[[2-(trifluoromethyl)phenyl]methylamino]pyrazine-2-carboxamide · in 2 records
- 91Y · 3-[(cyclohexanecarbonyl)amino]-N-(2,3-dihydro-1H-inden-2-yl)pyrazine-2-carboxamide · in 2 records
- BR · Bromide ion · in 2 records
- HFG · 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one · in 2 records
- MU5 · ~{N}-(2,3-dihydro-1~{H}-inden-2-yl)-3-(piperidin-1-ylcarbonylamino)pyrazine-2-carboxamide · in 2 records
- NO3 · Nitrate ion · in 2 records
- PO4 · Phosphate ion · in 2 records
- 1XK · 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide · in 1 record
- 8X1 · 5'-O-{[(2S)-azetidine-2-carbonyl]sulfamoyl}adenosine · in 1 record
- F96 · 1-[6-(3-fluorophenyl)benzimidazol-1-yl]-3-[(2R,3S)-3-oxidanylpiperidin-2-yl]propan-2-one · in 1 record
- F99 · 1-(5-chloranyl-4-methyl-benzimidazol-1-yl)-3-[(2R,3S)-3-oxidanylpiperidin-2-yl]propan-2-one · in 1 record
- F9C · 1-(6-bromanyl-7-methyl-imidazo[4,5-b]pyridin-3-yl)-3-[(2R,3S)-3-oxidanylpiperidin-2-yl]propan-2-one · in 1 record
- F9O · (2R,3S)-2-[3-[4,5-bis(chloranyl)benzimidazol-1-yl]propyl]piperidin-3-ol · in 1 record
Experiment against prediction
- 7X1O chain A against the predicted model P07814: TM-score 0.99, RMSD 0.72 Å
- 7X09 chain A against the predicted model P07814: TM-score 0.99, RMSD 0.79 Å
- 5V58 chain A against the predicted model P07814: TM-score 0.99, RMSD 0.92 Å
- 7F9C chain A against the predicted model P07814: TM-score 0.99, RMSD 0.97 Å
- 7BBU chain A against the predicted model P07814: TM-score 0.99, RMSD 0.97 Å
- 7F99 chain A against the predicted model P07814: TM-score 0.99, RMSD 0.96 Å
- 5V58 chain A against the predicted model P07814: TM-score 0.99, RMSD 0.92 Å
- 7F9C chain A against the predicted model P07814: TM-score 0.99, RMSD 0.97 Å
- 4HVC chain B against the predicted model P07814: TM-score 0.99, RMSD 1.06 Å
- 4HVC chain B against the predicted model P07814: TM-score 0.99, RMSD 1.06 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.