MolNFT v1 · #445447 · protein
AlphaFold monomer V2.0 prediction for bifunctional GLUTAMATE/PROLINE --tRNA ligase (P07814)
P07814 · Bifunctional GLUTAMATE/PROLINE--tRNA ligase: “AlphaFold monomer V2.0 prediction for bifunctional GLUTAMATE/PROLINE --tRNA ligase (P07814)”. 10 pockets (best druggability 0.76). MolNFT v1 #445447 on GenesisL1: 3D structure, binding…
- Accession
- P07814
- Type
- protein
- Length
- 1,512 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x848A4641291fcA75a40377EE7D18AD327aA697A7
- Molecule
- Bifunctional GLUTAMATE/PROLINE--tRNA ligase
- UniProt
- P07814
- Pockets
- 10 · best druggability 0.76
Structure
1 distinct chain · 37% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bifunctional GLUTAMATE/PROLINE--tRNA ligase | protein | 1512 | 37% helix, 20% strand | P07814 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 658 | 0.76 | 0.82 | 52 | empty |
| 2 | 505 | 0.71 | 0.80 | 49 | empty |
| 3 | 614 | 0.65 | 0.76 | 60 | empty |
| 4 | 83 | 0.65 | 0.91 | 23 | empty |
| 5 | 291 | 0.58 | 0.77 | 33 | empty |
Compared structures
- 7F9A · Homo sapiens Prolyl-tRNA Synthetase (HsPRS) in Complex with L-proline and compound L97 · an experimental structure of the same protein · chain A against A, TM-score 0.33
- 7OT2 · Human prolyl-tRNA synthetase in complex with L-proline and compound 4J · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 7OT0 · Human prolyl-tRNA synthetase in complex with L-proline and compound 4H · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 7OT0 · Human Prolyl-tRNA Synthetase in Complex with L-proline and Compound 4h · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 7OT3 · Human prolyl-tRNA synthetase in complex with L-proline and compound 3B · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 4K88 · Crystal structure of human prolyl-tRNA synthetase (halofugi bound form) · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 4K88 · Crystal structure of human prolyl-tRNA synthetase (halofuginone bound form) · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 4K87 · Crystal structure of human prolyl-tRNA synthetase (substrate bound form) · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 4K87 · Crystal structure of human prolyl-tRNA synthetase (substrate bound form) · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 7F9C · Homo sapiens prolyl-tRNA synthetase (hsprs) in complex with L-proline and compound L96 · an experimental structure of the same protein · chain A against A, TM-score 0.32
- 7F99 · Homo sapiens prolyl-tRNA synthetase (hsprs) in complex with L-proline and compound L96 · an experimental structure of the same protein · chain A against B, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07814
- Elsewhere: UniProt P07814 · AlphaFold DB P07814
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