MolNFT v1 · #113108 · protein
The crystal structure of the GST-like domains complex of eprs C92SC105SC123S mutant-AIMP2
5A5H · Bifunctional GLUTAMATE/PROLINE--tRNA ligase: “The crystal structure of the GST-like domains complex of eprs C92SC105SC123S mutant-AIMP2”. X-ray diffraction, 20 pockets (best druggability 0.72). MolNFT v1 #113108 on GenesisL1: 3D…
- PDB
- 5A5H
- Type
- protein
- Length
- 1,480 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bifunctional GLUTAMATE/PROLINE--tRNA ligase; Aminoacyl tRNA synthase complex-interacting…
- EC
- 6.1.1.15, 6.1.1.17
- UniProt
- P07814, Q13155
- Pockets
- 20 · best druggability 0.72
Structure
x-ray diffraction · 6 distinct chains · 48% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E | Bifunctional GLUTAMATE/PROLINE--tRNA ligase (EC 6.1.1.15, 6.1.1.17) | protein | 168 | 54% helix, 13% strand | P07814 |
| B | Aminoacyl tRNA synthase complex-interacting multifunctiona L protein 2 | protein | 210 | 42% helix, 13% strand | Q13155 |
| D | Aminoacyl tRNA synthase complex-interacting multifunctiona L protein 2 | protein | 213 | 48% helix, 13% strand | Q13155 |
| F | Aminoacyl tRNA synthase complex-interacting multifunctiona L protein 2 | protein | 195 | 45% helix, 14% strand | Q13155 |
| G | Bifunctional GLUTAMATE/PROLINE--tRNA ligase (EC 6.1.1.15, 6.1.1.17) | protein | 169 | 54% helix, 12% strand | P07814 |
| H | Aminoacyl tRNA synthase complex-interacting multifunctiona L protein 2 | protein | 189 | 49% helix, 14% strand | Q13155 |
Pockets
20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 829 | 0.72 | 0.77 | 96 | empty |
| 2 | 315 | 0.61 | 0.78 | 32 | empty |
| 3 | 251 | 0.60 | 0.80 | 35 | empty |
| 4 | 174 | 0.58 | 0.81 | 26 | empty |
| 5 | 164 | 0.58 | 0.82 | 26 | empty |
Interfaces
11 interfaces between chains.
- A–B · 1133 Ų buried · 14 hydrogen bonds · protein-protein
- G–H · 1075 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 1069 Ų buried · 9 hydrogen bonds · protein-protein
- E–F · 1017 Ų buried · 8 hydrogen bonds · protein-protein
- A–G · 557 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 5A5H · The crystal structure of the GST-like domains complex of EPRS C92SC105SC123S mutant-AIMP2 · the same entry in another collection · chain H against H, TM-score 1.00
- P07814 · AlphaFold monomer V2.0 prediction for bifunctional GLUTAMATE/PROLINE --tRNA ligase… · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q13155 · AlphaFold monomer V2.0 prediction for aminoacyl tRNA synthase complex-interacting… · a predicted model of the same protein · chain F against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07814
- Every structure of UniProt Q13155
- Elsewhere: RCSB PDB 5A5H · PDBe 5A5H · UniProt P07814 · UniProt Q13155
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.