UniProt P05024
Sodium/potassium-transporting ATPase subunit alpha-1 (P05024)
Sodium/potassium-transporting ATPase subunit alpha-1 (UniProt P05024), EC 7.2.2.13: 38 experimental structures and 1 predicted model on GenesisL1, 15 ligands bound, 220 pockets. Binding sites, druggability and experiment against…
- UniProt
- P05024
- Protein
- Sodium/potassium-transporting ATPase subunit alpha-1
- EC
- 7.2.2.13
- Experimental structures
- 38
- Predicted models
- 1
- Ligands
- 15
- Pockets
- 220 · 13 records with a druggable one
Structures
39 records of P05024 in the MolNFT archive: 38 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3B8E | Crystal structure of the sodium-potassium pump | x-ray diffraction | A, C | — | — |
| 3B8E | Crystal structure of the sodium-potassium pump | x-ray diffraction | A, C | — | — |
| 3KDP | Crystal structure of the sodium-potassium pump | x-ray diffraction | A, C | — | — |
| 3KDP | Crystal structure of the sodium-potassium pump | x-ray diffraction | A, C | — | — |
| 3N23 | Crystal structure of the high affinity complex between ouabain and the E2P form of the… | x-ray diffraction | A, C | — | — |
| 3N23 | Crystal structure of the high affinity complex between ouabain and the E2P form of the… | x-ray diffraction | A, C | — | — |
| 4HQJ | Crystal structure of Na+,K+-ATPase in the Na+-bound state | x-ray diffraction | A, C | — | — |
| 4HQJ | Crystal structure of NA+,K+-ATPase in the na+-bound state | x-ray diffraction | A, C | — | — |
| 4HYT | Na,K-ATPase in the E2P state with bound ouabain and Mg2+ in the cation-binding site | x-ray diffraction | A, C | — | — |
| 4HYT | NA,K-ATPase in the E2P state with bound ouabain and MG2+ in the cation-binding site | x-ray diffraction | A, C | — | — |
| 4RES | Crystal structure of the Na,K-ATPase E2P-bufalin complex with bound potassium | x-ray diffraction | A, C | — | — |
| 4RES | Crystal structure of the NA,K-ATPase E2P-bufalin complex with bound potassium | x-ray diffraction | A, C | — | — |
| 4RET | Crystal structure of the Na,K-ATPase E2P-digoxin complex with bound magnesium | x-ray diffraction | A, C | — | — |
| 4RET | Crystal structure of the NA,K-ATPase E2P-digoxin complex with bound magnesium | x-ray diffraction | A, C | — | — |
| 7D91 | Crystal Structure of the Na+,K+-ATPase in the E2P state with bound Mg2+ (P4(3)2(1)2 symmetry) | x-ray diffraction | A | MG, CLR, PCW | 15 (best 0.78) |
| 7D91 | Crystal structure of the NA+,K+-ATPase in the E2P state with bound MG2+ (P4(3)2(1)2 symmetry) | x-ray diffraction | A | MG, CLR, PCW | — |
| 7D92 | Crystal Structure of the Na+,K+-ATPase in the E2P state with bound Mg2+ and anthroylouabain… | x-ray diffraction | A | MG, CLR, PCW, H0C | 18 (best 0.78) |
| 7D92 | Crystal structure of the NA+,K+-ATPase in the E2P state with bound MG2+ and anthroylouabain… | x-ray diffraction | A | MG, CLR, PCW, H0C | — |
| 7D93 | Crystal Structure of the Na+,K+-ATPase in the E2P state with bound Mg2+ and anthroylouabain… | x-ray diffraction | A, C | MG, NA, CLR, PCW, H0C | 19 (best 0.79) |
| 7D93 | Crystal structure of the NA+,K+-ATPase in the E2P state with bound MG2+ and anthroylouabain… | x-ray diffraction | A, C | MG, NA, CLR, PCW, H0C | — |
| 7D94 | Crystal Structure of the Na+,K+-ATPase in the E2P state with bound one Mg2+ and one Rb+ in the… | x-ray diffraction | A, C | MG, NA, RB, CLR, PCW, BUF | 17 (best 0.79) |
| 7D94 | Crystal structure of the NA+,K+-ATPase in the E2P state with bound one MG2+ and one rb+ in the… | x-ray diffraction | A, C | MG, NA, RB, CLR, PCW, BUF | — |
| 7DDF | Crystal structures of NA+,K+-ATPase in complex with beryllium fluoride | x-ray diffraction | A, C | MG, NA, CLR, PCW | — |
| 7DDH | Crystal structures of Na+,K+-ATPase in complex with digoxin | x-ray diffraction | A, C | MG, NA, CLR, PCW, DGX | 16 (best 0.78) |
| 7DDH | Crystal structures of NA+,K+-ATPase in complex with digoxin | x-ray diffraction | A, C | MG, NA, CLR, PCW, DGX | — |
| 7DDI | Crystal structures of Na+,K+-ATPase in complex with digitoxin | x-ray diffraction | A, C | MG, NA, PCW, F9R, CLR | 16 (best 0.78) |
| 7DDI | Crystal structures of NA+,K+-ATPase in complex with digitoxin | x-ray diffraction | A, C | MG, NA, PCW, F9R, CLR | — |
| 7DDK | Crystal structures of Na+,K+-ATPase in complex with rostafuroxin | x-ray diffraction | A, C | MG, NA, PCW, E4R, CLR | 17 (best 0.79) |
| 7DDK | Crystal structures of NA+,K+-ATPase in complex with rostafuroxin | x-ray diffraction | A, C | MG, NA, PCW, E4R, CLR | — |
| 7DDL | Crystal structures of Na+,K+-ATPase in complex with bufalin | x-ray diffraction | A, C | MG, NA, PCW, BUF, CLR | 17 (best 0.79) |
| 7DDL | Crystal structures of NA+,K+-ATPase in complex with bufalin | x-ray diffraction | A, C | MG, NA, PCW, BUF, CLR | — |
| 7QTV | Beryllium fluoride form of the Na+,K+-ATPase (E2-BeFx) | x-ray diffraction | A, C | BEF, 1AT, CLR, 1DS, MG | 17 (best 0.78) |
| 7WYS | Crystal structures of Na+,K+-ATPase in complex with istaroxime | x-ray diffraction | A, C | MG, NA, PCW, 7Q2, CLR | 16 (best 0.82) |
| 7WYS | Crystal structures of NA+,K+-ATPase in complex with istaroxime | x-ray diffraction | A, C | MG, NA, PCW, 7Q2, CLR | — |
| 7WYT | Crystal structures of Na+,K+-ATPase in complex with ouabain | x-ray diffraction | A, C | MG, NA, CLR, PCW, OBN | 17 (best 0.78) |
| 7WYT | Crystal structures of NA+,K+-ATPase in complex with ouabain | x-ray diffraction | A, C | MG, NA, CLR, PCW, OBN | — |
| 7YZR | 50 mM Rb+ soak of beryllium fluoride inhibited Na+,K+-ATPase, E2-BeFx (rigid body model) | x-ray diffraction | A, C | MG, BEF | 18 (best 0.82) |
| 7Z04 | 10 mM Rb+ soak of beryllium fluoride inhibited Na+,K+-ATPase, E2-BeFx (rigid body model) | x-ray diffraction | A, C | BEF, MG | 17 (best 0.80) |
| P05024 | AlphaFold monomer V2.0 prediction for SODIUM/POTASSIUM-transporting ATPase subunit alpha-1 (P05024) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 24 records
- CLR · Cholesterol · in 22 records
- PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · in 21 records
- NA · Sodium ion · in 17 records
- BUF · bufalin · in 4 records
- H0C · [(2~{R},3~{R},4~{R},5~{S},6~{S})-2-[[(1~{R},3~{S}, 5~{S},8~{R},9~{S},10~{R},11~{R},13~{R},14~{S},17~{R})-10-(hydroxymethyl)-13-methyl-1,5,11,14-tetrakis(oxidanyl)-17-(5-oxidanylidene-2~{H}-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1~{H}-cyclopenta[a]phenanthren-3-yl]oxy]-6-methyl-3,5-bis(oxidanyl)oxan-4-yl] anthracene-9-carboxylate · in 4 records
- BEF · Beryllium trifluoride ion · in 3 records
- 7Q2 · (3E,5S,8R,9S,10R,13S,14S)-3-(2-azanylethoxyimino)-10, 13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione · in 2 records
- DGX · Digoxin · in 2 records
- E4R · (3S,5R,8R,9S,10S,13S,14S,17S)-17-(furan-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol · in 2 records
- F9R · Digitoxin · in 2 records
- OBN · Ouabain · in 2 records
- RB · Rubidium ion · in 2 records
- 1AT · beta-D-fructofuranosyl 6-O-decanoyl-alpha-D-glucopyranoside · in 1 record
- 1DS · 1-O-decanoyl-beta-D-tagatofuranosyl beta-D-allopyranoside · in 1 record
Experiment against prediction
- 7DDF chain A against the predicted model P05024: TM-score 0.98, RMSD 1.57 Å
- 7DDK chain A against the predicted model P05024: TM-score 0.98, RMSD 1.58 Å
- 7DDK chain A against the predicted model P05024: TM-score 0.98, RMSD 1.58 Å
- 7WYT chain A against the predicted model P05024: TM-score 0.98, RMSD 1.61 Å
- 7WYT chain A against the predicted model P05024: TM-score 0.98, RMSD 1.61 Å
- 7WYS chain A against the predicted model P05024: TM-score 0.98, RMSD 1.62 Å
- 7WYS chain A against the predicted model P05024: TM-score 0.98, RMSD 1.62 Å
- 7DDI chain A against the predicted model P05024: TM-score 0.98, RMSD 1.63 Å
- 7DDI chain A against the predicted model P05024: TM-score 0.98, RMSD 1.63 Å
- 7DDH chain A against the predicted model P05024: TM-score 0.98, RMSD 1.63 Å
Elsewhere
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