7Q2 · (3E,5S,8R,9S,10R,13S,14S)-3-(2-azanylethoxyimino)-10, 13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione

Binding sites

7Q2 in 6 structures; the first of them:

• 7WYS · Crystal structures of Na+,K+-ATPase in complex with istaroxime · 7Q2 A1109 · binds GLN111, GLU115, GLU116, GLU117, PRO118, GLN119, ASP121, ASN122 and 7 more
• 7WYX · Cryo-EM structure of Na+,K+-ATPase in the E2P state formed by ATP with istaroxime · 7Q2 A1104 · binds GLN118, ASN129, LEU132, GLY326, VAL329, ALA330, VAL332, GLU334 and 6 more
• 7WYY · Cryo-EM structure of Na+,K+-ATPase in the E2P state formed by inorganic phosphate with… · 7Q2 A1104 · binds GLN118, ASN129, LEU132, GLY326, VAL329, ALA330, VAL332, GLU334 and 5 more
• 7WYS · Crystal structures of NA+,K+-ATPase in complex with istaroxime · 7Q2 A1109 · binds GLN111, GLU115, GLU116, GLU117, PRO118, GLN119, ASP121, ASN122 and 5 more
• 7WYX · Cryo-EM structure of NA+,K+-ATPase in the E2P state formed by ATP with istaroxime · 7Q2 A1104 · binds GLN118, ASN129, LEU132, GLY326, VAL329, ALA330, VAL332, GLU334 and 4 more
• 7WYY · Cryo-EM structure of NA+,K+-ATPase in the E2P state formed by inorganic phosphate with… · 7Q2 A1104 · binds GLN118, ASN129, LEU132, GLY326, VAL329, ALA330, VAL332, GLU334 and 3 more

Residues it binds most

LEU 12, GLU 12, GLN 12, VAL 8, ALA 12, ASN 12, GLY 12, ILE 12, PHE 11, THR 10 (residue and the binding sites it lines).

Found with

• CLR · Cholesterol
• PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine
• MG · Magnesium ion
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
• NA · Sodium ion
• BMA · beta-D-mannopyranose
• FUC · alpha-L-fucopyranose
• MAN · alpha-D-mannopyranose
• ATP · Adenosine-5'-triphosphate