MolNFT v1 · #176165 · protein
Crystal structures of NA+,K+-ATPase in complex with rostafuroxin
7DDK: “Crystal structures of NA+,K+-ATPase in complex with rostafuroxin”. X-ray diffraction, 6 ligands (PCW, CLR, E4R). MolNFT v1 #176165 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7DDK
- Type
- protein
- Length
- 2,632 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P05024, P05027, Q58K79
- Ligands
- PCW, CLR, E4R, NAG, MG, NA
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | — | protein | 996 | — | P05024 |
| B | — | protein | 291 | — | P05027 |
| G, E | — | protein | 32 | — | Q58K79 |
| D | — | protein | 285 | — | P05027 |
Ligands and binding sites
- PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · ligand · 13 copies · chains A, B, D, C, E, G
- CLR · Cholesterol · ligand · 6 copies · chains A, B, C, G, D, E
- E4R · (3S,5R,8R,9S,10S,13S,14S,17S)-17-(furan-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol · ligand · 2 copies · chains A, C
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 10 copies · chains B, D
- MG · Magnesium ion · metal · 4 copies · chains A, C
- NA · Sodium ion · metal · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7DDK · Crystal structures of Na+,K+-ATPase in complex with rostafuroxin · the same entry in another collection · chain G against G, TM-score 1.00
- P05024 · AlphaFold monomer V2.0 prediction for SODIUM/POTASSIUM-transporting ATPase subunit… · a predicted model of the same protein · chain A against A, TM-score 0.98
- P05027 · AlphaFold monomer V2.0 prediction for SODIUM/POTASSIUM-transporting ATPase subunit beta-1… · a predicted model of the same protein · chain D against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05024
- Every structure of UniProt P05027
- Every structure of UniProt Q58K79
- Elsewhere: RCSB PDB 7DDK · PDBe 7DDK · UniProt P05024 · UniProt P05027 · UniProt Q58K79
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