UniProt P05027

Sodium/potassium-transporting ATPase subunit beta-1 (P05027)

Sodium/potassium-transporting ATPase subunit beta-1 (UniProt P05027): 40 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 94 pockets. Binding sites, druggability and experiment against prediction…

UniProt: P05027
Protein: Sodium/potassium-transporting ATPase subunit beta-1
Experimental structures: 40
Predicted models: 1
Ligands: 6
Pockets: 94 · 11 records with a druggable one

Structures

41 records of P05027 in the MolNFT archive: 40 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
3B8E	Crystal structure of the sodium-potassium pump	x-ray diffraction	B, D	—	—
3B8E	Crystal structure of the sodium-potassium pump	x-ray diffraction	B, D	—	—
3KDP	Crystal structure of the sodium-potassium pump	x-ray diffraction	B, D	—	—
3KDP	Crystal structure of the sodium-potassium pump	x-ray diffraction	B, D	—	—
3N23	Crystal structure of the high affinity complex between ouabain and the E2P form of the…	x-ray diffraction	B, D	—	—
3N23	Crystal structure of the high affinity complex between ouabain and the E2P form of the…	x-ray diffraction	B, D	—	—
3WGU	Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state without oligomycin	x-ray diffraction	B, D	—	—
3WGU	Crystal structure of a na+-bound NA+,K+-ATPase preceding the E1P state without oligomycin	x-ray diffraction	B, D	—	—
3WGV	Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state with oligomycin	x-ray diffraction	B, D	—	—
3WGV	Crystal structure of a na+-bound NA+,K+-ATPase preceding the E1P state with oligomycin	x-ray diffraction	B, D	—	—
4HQJ	Crystal structure of Na+,K+-ATPase in the Na+-bound state	x-ray diffraction	B, D	—	—
4HQJ	Crystal structure of NA+,K+-ATPase in the na+-bound state	x-ray diffraction	B, D	—	—
4HYT	Na,K-ATPase in the E2P state with bound ouabain and Mg2+ in the cation-binding site	x-ray diffraction	B, D	—	—
4HYT	NA,K-ATPase in the E2P state with bound ouabain and MG2+ in the cation-binding site	x-ray diffraction	B, D	—	—
4RES	Crystal structure of the Na,K-ATPase E2P-bufalin complex with bound potassium	x-ray diffraction	B, D	—	—
4RES	Crystal structure of the NA,K-ATPase E2P-bufalin complex with bound potassium	x-ray diffraction	B, D	—	—
4RET	Crystal structure of the Na,K-ATPase E2P-digoxin complex with bound magnesium	x-ray diffraction	B, D	—	—
4RET	Crystal structure of the NA,K-ATPase E2P-digoxin complex with bound magnesium	x-ray diffraction	B, D	—	—
7D91	Crystal Structure of the Na+,K+-ATPase in the E2P state with bound Mg2+ (P4(3)2(1)2 symmetry)	x-ray diffraction	B	NAG, CLR, PCW	5 (best 0.78)
7D91	Crystal structure of the NA+,K+-ATPase in the E2P state with bound MG2+ (P4(3)2(1)2 symmetry)	x-ray diffraction	B	NAG, CLR, PCW	—
7D92	Crystal Structure of the Na+,K+-ATPase in the E2P state with bound Mg2+ and anthroylouabain…	x-ray diffraction	B	NAG, CLR, PCW	7 (best 0.78)
7D92	Crystal structure of the NA+,K+-ATPase in the E2P state with bound MG2+ and anthroylouabain…	x-ray diffraction	B	NAG, CLR, PCW	—
7D93	Crystal Structure of the Na+,K+-ATPase in the E2P state with bound Mg2+ and anthroylouabain…	x-ray diffraction	B, D	NAG, CLR, PCW	8 (best 0.79)
7D93	Crystal structure of the NA+,K+-ATPase in the E2P state with bound MG2+ and anthroylouabain…	x-ray diffraction	B, D	NAG, CLR, PCW	—
7D94	Crystal Structure of the Na+,K+-ATPase in the E2P state with bound one Mg2+ and one Rb+ in the…	x-ray diffraction	B, D	NAG, CLR, PCW	9 (best 0.79)
7D94	Crystal structure of the NA+,K+-ATPase in the E2P state with bound one MG2+ and one rb+ in the…	x-ray diffraction	B, D	NAG, CLR, PCW	—
7DDF	Crystal structures of NA+,K+-ATPase in complex with beryllium fluoride	x-ray diffraction	B, D	NAG, CLR, PCW	—
7DDH	Crystal structures of Na+,K+-ATPase in complex with digoxin	x-ray diffraction	B, D	NAG, CLR, PCW, DGX	11 (best 0.78)
7DDH	Crystal structures of NA+,K+-ATPase in complex with digoxin	x-ray diffraction	B, D	NAG, CLR, PCW, DGX	—
7DDI	Crystal structures of Na+,K+-ATPase in complex with digitoxin	x-ray diffraction	B, D	NAG, PCW, F9R, CLR	10 (best 0.78)
7DDI	Crystal structures of NA+,K+-ATPase in complex with digitoxin	x-ray diffraction	B, D	NAG, PCW, F9R, CLR	—
7DDK	Crystal structures of NA+,K+-ATPase in complex with rostafuroxin	x-ray diffraction	B, D	NAG, PCW, CLR	—
7DDL	Crystal structures of Na+,K+-ATPase in complex with bufalin	x-ray diffraction	B, D	NAG, PCW, CLR	9 (best 0.79)
7DDL	Crystal structures of NA+,K+-ATPase in complex with bufalin	x-ray diffraction	B, D	NAG, PCW, CLR	—
7WYS	Crystal structures of Na+,K+-ATPase in complex with istaroxime	x-ray diffraction	B, D	NAG, PCW, CLR	10 (best 0.82)
7WYS	Crystal structures of NA+,K+-ATPase in complex with istaroxime	x-ray diffraction	B, D	NAG, PCW, CLR	—
7WYT	Crystal structures of NA+,K+-ATPase in complex with ouabain	x-ray diffraction	B, D	NAG, CLR, PCW	—
7YZR	50 mM Rb+ soak of beryllium fluoride inhibited Na+,K+-ATPase, E2-BeFx (rigid body model)	x-ray diffraction	B, D	—	9 (best 0.81)
7Z04	10 mM Rb+ soak of beryllium fluoride inhibited Na+,K+-ATPase, E2-BeFx (rigid body model)	x-ray diffraction	B, D	—	8 (best 0.80)
8JBK	Crystal structure of Na+,K+-ATPase in the E1.3Na+ state	x-ray diffraction	B, D	NAG, CLR, PC1, PCW	8 (best 0.77)
P05027	AlphaFold monomer V2.0 prediction for SODIUM/POTASSIUM-transporting ATPase subunit beta-1 (P05027)	predicted	A	—	—

Ligands

CLR · Cholesterol · in 20 records
NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 20 records
PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · in 20 records
DGX · Digoxin · in 2 records
F9R · Digitoxin · in 2 records
PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 1 record

Experiment against prediction

8JBK chain B against the predicted model P05027: TM-score 0.98, RMSD 0.87 Å
8JBK chain D against the predicted model P05027: TM-score 0.98, RMSD 0.94 Å
7WYT chain D against the predicted model P05027: TM-score 0.98, RMSD 0.86 Å
7DDI chain D against the predicted model P05027: TM-score 0.98, RMSD 0.88 Å
7DDI chain D against the predicted model P05027: TM-score 0.98, RMSD 0.88 Å
7DDL chain D against the predicted model P05027: TM-score 0.98, RMSD 0.89 Å
7DDL chain D against the predicted model P05027: TM-score 0.98, RMSD 0.89 Å
7WYS chain D against the predicted model P05027: TM-score 0.98, RMSD 0.89 Å
7WYS chain D against the predicted model P05027: TM-score 0.98, RMSD 0.89 Å
7DDF chain D against the predicted model P05027: TM-score 0.98, RMSD 0.90 Å

Elsewhere

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