UniProt P04825
Aminopeptidase N (P04825)
Aminopeptidase N (UniProt P04825), EC 3.4.11.2: 81 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 60 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P04825
- Protein
- Aminopeptidase N
- EC
- 3.4.11.2
- Experimental structures
- 81
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 60 · 6 records with a druggable one
Structures
82 records of P04825 in the MolNFT archive: 81 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2DQ6 | Crystal Structure of Aminopeptidase N from Escherichia coli | x-ray diffraction | A | — | — |
| 2DQ6 | Crystal structure of aminopeptidase N from escherichia COLI | x-ray diffraction | A | — | — |
| 2DQM | Crystal Structure of Aminopeptidase N complexed with bestatin | x-ray diffraction | A | — | — |
| 2DQM | Crystal structure of aminopeptidase N complexed with bestatin | x-ray diffraction | A | — | — |
| 2HPO | Structure of Aminopeptidase N from E. coli Suggests a Compartmentalized, Gated Active Site | x-ray diffraction | A | — | — |
| 2HPO | Structure of aminopeptidase N from E. COLI suggests a compartmentalized, gated active site | x-ray diffraction | A | — | — |
| 2HPT | Crystal Structure of E. coli PepN (Aminopeptidase N)in complex with Bestatin | x-ray diffraction | A | — | — |
| 2HPT | Crystal structure of E. COLI pepn (aminopeptidase N)IN complex with bestatin | x-ray diffraction | A | — | — |
| 2ZXG | Aminopeptidase N complexed with the aminophosphinic inhibitor of PL250, a transition state analogue | x-ray diffraction | A | — | — |
| 2ZXG | Aminopeptidase N complexed with the aminophosphinic inhibitor of PL250, a transition state analogue | x-ray diffraction | A | — | — |
| 3B2P | Crystal structure of E. coli Aminopeptidase N in complex with arginine | x-ray diffraction | A | — | — |
| 3B2P | Crystal structure of E. COLI aminopeptidase N in complex with arginine | x-ray diffraction | A | — | — |
| 3B2X | Crystal Structure of E. coli Aminopeptidase N in complex with Lysine | x-ray diffraction | A | — | — |
| 3B2X | Crystal structure of E. COLI aminopeptidase N in complex with lysine | x-ray diffraction | A | — | — |
| 3B34 | Crystal structure of E. coli Aminopeptidase N in complex with Phenylalanine | x-ray diffraction | A | — | — |
| 3B34 | Crystal structure of E. COLI aminopeptidase N in complex with phenylalanine | x-ray diffraction | A | — | — |
| 3B37 | Crystal structure of E. coli Aminopeptidase N in complex with Tyrosine | x-ray diffraction | A | — | — |
| 3B37 | Crystal structure of E. COLI aminopeptidase N in complex with tyrosine | x-ray diffraction | A | — | — |
| 3B3B | Crystal structure of E. coli Aminopeptidase N in complex with tryptophan | x-ray diffraction | A | — | — |
| 3B3B | Crystal structure of E. COLI aminopeptidase N in complex with tryptophan | x-ray diffraction | A | — | — |
| 3KED | Crystal structure of Aminopeptidase N in complex with 2,4-diaminobutyric acid | x-ray diffraction | A | — | — |
| 3KED | Crystal structure of aminopeptidase N in complex with 2,4- diaminobutyric acid | x-ray diffraction | A | — | — |
| 3PUU | Crystal Structure of Glu121Gln mutant of E. coli Aminopeptidase N | x-ray diffraction | A | — | — |
| 3PUU | Crystal structure of GLU121GLN mutant of E. COLI aminopeptidase N | x-ray diffraction | A | — | — |
| 3QJX | Crystal Structure of E. coli Aminopeptidase N in complex with L-Serine | x-ray diffraction | A | — | — |
| 3QJX | Crystal structure of E. COLI aminopeptidase N in complex with L-serine | x-ray diffraction | A | — | — |
| 4Q4E | Crystal structure of E.coli aminopeptidase N in complex with actinonin | x-ray diffraction | A | — | — |
| 4Q4E | Crystal structure of E.COLI aminopeptidase N in complex with actinonin | x-ray diffraction | A | — | — |
| 4Q4I | Crystal structure of E.coli aminopeptidase N in complex with amastatin | x-ray diffraction | A | — | — |
| 4Q4I | Crystal structure of E.COLI aminopeptidase N in complex with amastatin | x-ray diffraction | A | — | — |
| 4XMT | Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with… | x-ray diffraction | A | — | — |
| 4XMT | Crystal structure of MET260ALA mutant of E. COLI aminopeptidase N in complex with… | x-ray diffraction | A | — | — |
| 4XMU | Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-Alanine | x-ray diffraction | A | — | — |
| 4XMU | Crystal structure of MET260ALA mutant of E. COLI aminopeptidase N in complex with L-alanine | x-ray diffraction | A | — | — |
| 4XMV | Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-Arginine | x-ray diffraction | A | — | — |
| 4XMV | Crystal structure of MET260ALA mutant of E. COLI aminopeptidase N in complex with L-arginine | x-ray diffraction | A | — | — |
| 4XMW | Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-aspartic acid | x-ray diffraction | A | ZN, ASP, NA | 8 (best 0.82) |
| 4XMW | Crystal structure of MET260ALA mutant of E. COLI aminopeptidase N in complex with L-aspartic acid | x-ray diffraction | A | — | — |
| 4XMX | Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with Bestatin | x-ray diffraction | A | — | — |
| 4XMX | Crystal structure of MET260ALA mutant of E. COLI aminopeptidase N in complex with bestatin | x-ray diffraction | A | — | — |
| 4XMZ | Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with… | x-ray diffraction | A | — | — |
| 4XMZ | Crystal structure of MET260ALA mutant of E. COLI aminopeptidase N in complex with… | x-ray diffraction | A | — | — |
| 4XN1 | Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-Glutamate | x-ray diffraction | A | — | — |
| 4XN1 | Crystal structure of MET260ALA mutant of E. COLI aminopeptidase N in complex with L-glutamate | x-ray diffraction | A | — | — |
| 4XN2 | Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-Leucine | x-ray diffraction | A | — | — |
| 4XN2 | Crystal structure of MET260ALA mutant of E. COLI aminopeptidase N in complex with L-leucine | x-ray diffraction | A | — | — |
| 4XN4 | Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-Methionine | x-ray diffraction | A | — | — |
| 4XN4 | Crystal structure of MET260ALA mutant of E. COLI aminopeptidase N in complex with L-methionine | x-ray diffraction | A | — | — |
| 4XN5 | Crystal Structure of Met260Ala mutant of E. coli Aminopeptidase N in complex with L-Phenylalanine | x-ray diffraction | A | ZN, PHE, NA | 13 (best 0.81) |
| 4XN5 | Crystal structure of MET260ALA mutant of E. COLI aminopeptidase N in complex with L-phenylalanine | x-ray diffraction | A | — | — |
| 4XN7 | Crystal Structure of E. coli Aminopeptidase N in complex with L-2,3-Diaminopropionic acid | x-ray diffraction | A | ZN, DPP, NA | 9 (best 0.84) |
| 4XN7 | Crystal structure of E. COLI aminopeptidase N in complex with L-2,3- diaminopropionic acid | x-ray diffraction | A | — | — |
| 4XN8 | Crystal Structure of E. coli Aminopeptidase N in complex with L-Alanine | x-ray diffraction | A | — | — |
| 4XN8 | Crystal structure of E. COLI aminopeptidase N in complex with L- alanine | x-ray diffraction | A | — | — |
| 4XN9 | Crystal Structure of E. coli Aminopeptidase N in complex with Beta Alanine | x-ray diffraction | A | — | — |
| 4XN9 | Crystal structure of E. COLI aminopeptidase N in complex with beta alanine | x-ray diffraction | A | — | — |
| 4XNA | Crystal Structure of E. coli Aminopeptidase N in complex with L-Beta Homolysine | x-ray diffraction | A | — | — |
| 4XNA | Crystal structure of E. COLI aminopeptidase N in complex with L-beta homolysine | x-ray diffraction | A | — | — |
| 4XNB | Crystal Structure of E. coli Aminopeptidase N in complex with L-Beta Homophenylalanine | x-ray diffraction | A | — | — |
| 4XNB | Crystal structure of E. COLI aminopeptidase N in complex with L-beta homophenylalanine | x-ray diffraction | A | — | — |
22 records more on the page itself.
Ligands
- ZN · Zinc ion · in 16 records
- NA · Sodium ion · in 12 records
- CL · Chloride ion · in 6 records
- 7MF · [(7~{S})-1-bromanyl-6,6-bis(oxidanyl)-4-phenyl-5,7,8,9-tetrahydrobenzo[7]annulen-7-yl]azanium · in 4 records
- 7MK · [(7~{S})-6,6-bis(oxidanyl)-5,7,8,9-tetrahydrobenzo[7]annulen-7-yl]azanium · in 2 records
- 7ML · [(7~{S})-6,6-bis(oxidanyl)-4-phenyl-5,7,8,9-tetrahydrobenzo[7]annulen-7-yl]azanium · in 2 records
- GMC · (2R,3R,4S,5S)-4-amino-2-[6-(dimethylamino)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydro-3-furanol · in 2 records
- ASP · Aspartic acid · in 1 record
- DPP · Diaminopropanoic acid · in 1 record
- PHE · Phenylalanine · in 1 record
Experiment against prediction
- 2HPT chain A against the predicted model P04825: TM-score 1.00, RMSD 0.56 Å
- 2HPT chain A against the predicted model P04825: TM-score 1.00, RMSD 0.56 Å
- 4XN5 chain A against the predicted model P04825: TM-score 1.00, RMSD 0.56 Å
- 5MFS chain A against the predicted model P04825: TM-score 1.00, RMSD 0.56 Å
- 5MFS chain A against the predicted model P04825: TM-score 1.00, RMSD 0.56 Å
- 5MFR chain A against the predicted model P04825: TM-score 1.00, RMSD 0.57 Å
- 5MFR chain A against the predicted model P04825: TM-score 1.00, RMSD 0.57 Å
- 4XMX chain A against the predicted model P04825: TM-score 1.00, RMSD 0.57 Å
- 4XMX chain A against the predicted model P04825: TM-score 1.00, RMSD 0.57 Å
- 2ZXG chain A against the predicted model P04825: TM-score 1.00, RMSD 0.57 Å
Elsewhere
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