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Ligand · PUY

PUY · Puromycin

PUY, Puromycin (C22 H29 N7 O5, 471.5 g/mol), in the MolNFT structures on GenesisL1: bound in 12 records (6 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
PUY
Formula
C22 H29 N7 O5
Class
ligand
Structures
12
PDB entries
6

Binding sites

PUY in 12 structures; the first of them:

  • 1Q7Y · Crystal Structure of CCdAP-Puromycin bound at the Peptidyl transferase center of the 50S… · PUY 578 · binds G2102, A2486, C2487, G2540, U2541, C2542, G2588, G2618 and 4 more
  • 2DPT · Leucyl/phenylalanyl-tRNA-protein transferase complexed with puromycin · PUY A501 · binds ASN24, PHE47, TRP49, TRP59, GLU108, MET144, TYR145, PHE153 and 11 more
  • 3Q3D · Crystal structure of BmrR bound to puromycin · PUY A6409 · binds PRO144, VAL147, LEU148, ASN149, TYR152, TYR170, GLY171, ALA172 and 8 more
  • 4TVA · Universal Pathway for Post-Transfer Editing Reactions: Insight from Crystal structure of… · PUY B801 · binds ARG240, ILE242, VAL246, THR249, ASN250, MET253, PRO259, MET260 and 11 more
  • 5NC5 · Crystal structure of AcrBZ in complex with antibiotic puromycin · PUY B1120 · binds SER134, PHE136, VAL139, PHE178, TYR327, MET573, PHE615, PHE617 and 6 more
  • 5YO1 · Structure of ePepN E298A mutant in complex with Puromycin · PUY A902 · binds MET260, GLY261, ARG293, VAL294, HIS297, VAL324, ASP327, TYR376 and 10 more
  • 1Q7Y · Crystal structure of ccdap-puromycin bound at the peptidyl transferase center of the 50S… · PUY 578 · binds G2102, A2486, C2487, G2540, U2541, C2542, G2588, G2618 and 4 more
  • 2DPT · LEUCYL/PHENYLALANYL-tRNA-protein transferase complexed with puromycin · PUY A501 · binds ASN24, PHE47, TRP49, TRP59, GLU108, MET144, TYR145, PHE153 and 11 more
  • 3Q3D · Crystal structure of bmrr bound to puromycin · PUY A6409 · binds PRO144, VAL147, LEU148, ASN149, TYR152, TYR170, GLY171, ALA172 and 8 more
  • 4TVA · Universal pathway for post-transfer editing reactions: insight from crystal structure of… · PUY B801 · binds ARG240, ILE242, VAL246, THR249, ASN250, MET253, PRO259, MET260 and 11 more
  • 5NC5 · Crystal structure of acrbz in complex with antibiotic puromycin · PUY B1120 · binds SER134, PHE136, VAL139, PHE178, TYR327, MET573, PHE615, PHE617 and 6 more
  • 5YO1 · Structure of epepn E298A mutant in complex with puromycin · PUY A902 · binds MET260, GLY261, ARG293, VAL294, HIS297, VAL324, ASP327, TYR376 and 10 more

Residues it binds most

PHE 10, TYR 12, GLU 12, LEU 14, VAL 14, MET 10, GLY 10, ARG 6, PRO 10, ASN 8 (residue and the binding sites it lines).

Found with

  • NA · Sodium ion
  • D10 · Decane
  • D12 · Dodecane
  • PHE · Phenylalanine
  • CD · Cadmium ion
  • K · Potassium ion
  • MG · Magnesium ion
  • ZN · Zinc ion
  • CL · Chloride ion
  • PO4 · Phosphate ion
  • DD9 · nonane
  • GOL · Glycerol

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