UniProt P02545
Prelamin-A/C (P02545)
Prelamin-A/C (UniProt P02545): 40 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 45 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P02545
- Protein
- Prelamin-A/C
- Experimental structures
- 40
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 45 · 8 records with a druggable one
Structures
41 records of P02545 in the MolNFT archive: 40 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1IFR | Structure of Lamin A/C Globular Domain | x-ray diffraction | A | — | — |
| 1IFR | Structure of lamin A/C globular domain | x-ray diffraction | A | — | — |
| 1IVT | NMR structures of the C-terminal globular domain of human lamin A/C | solution nmr | A | — | — |
| 1IVT | NMR structures of the C-terminal globular domain of human lamin A/C | solution nmr | A | — | — |
| 1X8Y | Human lamin coil 2B | x-ray diffraction | A | — | — |
| 1X8Y | Human lamin coil 2B | x-ray diffraction | A | — | — |
| 2XV5 | Human lamin A coil 2B fragment | x-ray diffraction | A, B | — | — |
| 2XV5 | Human lamin a coil 2B fragment | x-ray diffraction | A, B | — | — |
| 2YPT | Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 mutant (E336A) in… | x-ray diffraction | F, G, H, I | — | — |
| 2YPT | Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 mutant (E336A) in… | x-ray diffraction | F, G, H, I | — | — |
| 3GEF | Crystal structure of the R482W mutant of lamin A/C | x-ray diffraction | A, B, C, D | — | — |
| 3GEF | Crystal structure of the R482W mutant of lamin A/C | x-ray diffraction | A, B, C, D | — | — |
| 3V4Q | Structure of R335W mutant of human Lamin | x-ray diffraction | A | — | — |
| 3V4Q | Structure of R335W mutant of human lamin | x-ray diffraction | A | — | — |
| 3V4W | Structure of E347K mutant of Lamin | x-ray diffraction | A | — | — |
| 3V4W | Structure of E347K mutant of lamin | x-ray diffraction | A | — | — |
| 3V5B | Structure of Coil 2b of human lamin | x-ray diffraction | A | — | — |
| 3V5B | Structure of coil 2B of human lamin | x-ray diffraction | A | — | — |
| 6GHD | Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an… | x-ray diffraction | B, F | — | 8 (best 0.39) |
| 6GHD | Structural analysis of the ternary complex between lamin A/C, baf and emerin identifies an… | x-ray diffraction | B, F | — | — |
| 6JLB | Crystal structure of lamin A/C fragment and assembly mechanisms of intermediate filaments | x-ray diffraction | A, B, C, D | — | 9 (best 0.75) |
| 6JLB | Crystal structure of lamin A/C fragment and assembly mechanisms of intermediate filaments | x-ray diffraction | A, B, C, D | — | — |
| 6RPR | LEM domain of Emerin mutant T43I in complex with BAF dimer and the Igfold of the lamin A/C | x-ray diffraction | B | — | 1 (best 0.37) |
| 6RPR | Lem domain of emerin mutant T43I in complex with baf dimer and the igfold of the lamin A/C | x-ray diffraction | B | — | — |
| 6SNZ | Crystal structure of lamin A coil1b tetramer | x-ray diffraction | A, B, C, D | — | 6 (best 0.51) |
| 6SNZ | Crystal structure of lamin a COIL1B tetramer | x-ray diffraction | A, B, C, D | — | — |
| 6YF5 | Lamin A 17-70 coil1A dimer stabilized by C-terminal capping | x-ray diffraction | A, B, C, D | — | 2 (best 0.72) |
| 6YF5 | Lamin a 17-70 COIL1A dimer stabilized by C-terminal capping | x-ray diffraction | A, B, C, D | — | — |
| 6YJD | Lamin A coil2 dimer stabilized by N-terminal capping | x-ray diffraction | A | NI, CL | — |
| 6YJD | Lamin a COIL2 dimer stabilized by N-terminal capping | x-ray diffraction | A | NI, CL | — |
| 6YSH | Lamin A 1-70 coil1A dimer stabilized by C-terminal capping | x-ray diffraction | A, B | — | 1 (best 0.30) |
| 6YSH | Lamin a 1-70 COIL1A dimer stabilized by C-terminal capping | x-ray diffraction | A, B | — | — |
| 7CRG | Beta-strand-mediated dimeric formation of the extended Ig-like domains of human lamin A/C | x-ray diffraction | A, B, C | — | 3 (best 0.52) |
| 7CRG | Beta-strand-mediated dimeric formation of the extended ig-like domains of human lamin A/C | x-ray diffraction | A, B, C | — | 3 (best 0.52) |
| 7D9N | Crystal structure of a non-canonic progeria mutation S143F at lamin A/C and its structural… | x-ray diffraction | A, B | — | — |
| 7D9N | Crystal structure of a non-canonic progeria mutation S143F at lamin A/C and its structural… | x-ray diffraction | A, B | — | — |
| 7X5D | Crystal Structure of the K316C mutant of Human Lamin A/C Coil 2 (residues 244-340) | x-ray diffraction | A, B | — | — |
| 7YVD | The crystal structure of the progerin C-terminal peptide and the Ig-like domain of lamin A/C | x-ray diffraction | A, B, C | SEC | 2 (best 0.52) |
| 7Z21 | BAF A12T bound to the lamin A/C Ig-fold domain | x-ray diffraction | E, F | — | 5 (best 0.76) |
| 7Z21 | Baf A12T bound to the lamin A/C ig-fold domain | x-ray diffraction | E, F | — | 5 (best 0.76) |
| P02545 | AlphaFold monomer V2.0 prediction for prelamin-A/C (P02545) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6GHD chain F against the predicted model P02545: TM-score 0.99, RMSD 0.45 Å
- 6GHD chain F against the predicted model P02545: TM-score 0.99, RMSD 0.45 Å
- 6RPR chain B against the predicted model P02545: TM-score 0.99, RMSD 0.44 Å
- 6RPR chain B against the predicted model P02545: TM-score 0.99, RMSD 0.44 Å
- 1IFR chain A against the predicted model P02545: TM-score 0.98, RMSD 0.52 Å
- 1IFR chain A against the predicted model P02545: TM-score 0.98, RMSD 0.52 Å
- 6GHD chain B against the predicted model P02545: TM-score 0.98, RMSD 0.66 Å
- 6GHD chain B against the predicted model P02545: TM-score 0.98, RMSD 0.66 Å
- 7Z21 chain F against the predicted model P02545: TM-score 0.98, RMSD 0.61 Å
- 7Z21 chain E against the predicted model P02545: TM-score 0.98, RMSD 0.62 Å
Elsewhere
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