MolNFT v1 · #153662 · protein
Crystal structure of lamin A/C fragment and assembly mechanisms of intermediate filaments
6JLB: “Crystal structure of lamin A/C fragment and assembly mechanisms of intermediate filaments”. X-ray diffraction, 9 pockets (best druggability 0.75). MolNFT v1 #153662 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6JLB
- Type
- protein
- Length
- 886 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lamin A/C
- UniProt
- P02545
- Pockets
- 9 · best druggability 0.75
Structure
x-ray diffraction · 4 distinct chains · 97% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lamin A/C | protein | 202 | 98% helix, 0% strand | P02545 |
| B | Lamin A/C | protein | 207 | 97% helix, 0% strand | P02545 |
| C | Lamin A/C | protein | 256 | 98% helix, 0% strand | P02545 |
| D | Lamin A/C | protein | 221 | 96% helix, 0% strand | P02545 |
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 876 | 0.75 | 0.79 | 61 | empty |
| 2 | 358 | 0.64 | 0.79 | 40 | empty |
| 3 | 190 | 0.49 | 0.76 | 22 | empty |
| 4 | 84 | 0.40 | 0.78 | 20 | empty |
| 5 | 140 | 0.39 | 0.73 | 24 | empty |
Interfaces
6 interfaces between chains.
- C–D · 5960 Ų buried · 25 hydrogen bonds · protein-protein
- A–B · 5368 Ų buried · 23 hydrogen bonds · protein-protein
- A–C · 1374 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 567 Ų buried · 4 hydrogen bonds · protein-protein
- B–D · 453 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 6JLB · Crystal structure of lamin A/C fragment and assembly mechanisms of intermediate filaments · the same entry in another collection · chain D against D, TM-score 1.00
- P02545 · AlphaFold monomer V2.0 prediction for prelamin-A/C (P02545) · a predicted model of the same protein · chain B against A, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02545
- Elsewhere: RCSB PDB 6JLB · PDBe 6JLB · UniProt P02545
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