MolNFT v1 · #170678 · protein

Lamin a 17-70 COIL1A dimer stabilized by C-terminal capping

6YF5 · Prelamin-A/C,MICROTUBULE-associated protein RP/EB family…: “Lamin a 17-70 COIL1A dimer stabilized by C-terminal capping”. X-ray diffraction, 2 pockets (best druggability 0.72). MolNFT v1 #170678 on GenesisL1: 3D structure, binding…

PDB: 6YF5
Type: protein
Length: 341 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Prelamin-A/C,MICROTUBULE-associated protein RP/EB family member 1
UniProt: P02545, Q15691
Pockets: 2 · best druggability 0.72

Structure

x-ray diffraction · 4 distinct chains · 84% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Prelamin-A/C,MICROTUBULE-associated protein RP/EB family member 1	protein	89	81% helix, 3% strand	P02545, Q15691
B	Prelamin-A/C,MICROTUBULE-associated protein RP/EB family member 1	protein	83	88% helix, 4% strand	P02545, Q15691
C	Prelamin-A/C,MICROTUBULE-associated protein RP/EB family member 1	protein	87	79% helix, 1% strand	P02545, Q15691
D	Prelamin-A/C,MICROTUBULE-associated protein RP/EB family member 1	protein	82	89% helix, 1% strand	P02545, Q15691

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	693	0.72	0.78	64	empty
2	77	0.44	0.81	16	empty

Interfaces

6 interfaces between chains.

C–D · 2486 Å² buried · 32 hydrogen bonds · protein-protein
A–B · 2462 Å² buried · 21 hydrogen bonds · protein-protein
A–C · 313 Å² buried · 8 hydrogen bonds · protein-protein
A–D · 292 Å² buried · 6 hydrogen bonds · protein-protein
B–C · 219 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

6YF5 · Lamin A 17-70 coil1A dimer stabilized by C-terminal capping · the same entry in another collection · chain D against D, TM-score 1.00
P02545 · AlphaFold monomer V2.0 prediction for prelamin-A/C (P02545) · a predicted model of the same protein · chain B against A, TM-score 0.73

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02545
Every structure of UniProt Q15691
Elsewhere: RCSB PDB 6YF5 · PDBe 6YF5 · UniProt P02545 · UniProt Q15691

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