UniProt P00918
carbonic anhydrase 2 (P00918)
carbonic anhydrase 2 (UniProt P00918), EC 4.2.1.1, 4.2.1.69: 1,764 experimental structures and 1 predicted model on GenesisL1, 358 ligands bound, 147 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P00918
- Protein
- carbonic anhydrase 2
- EC
- 4.2.1.1, 4.2.1.69
- Experimental structures
- 1,764
- Predicted models
- 1
- Ligands
- 358
- Pockets
- 147 · 117 records with a druggable one
Structures
1,765 records of P00918 in the MolNFT archive: 1764 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 12CA | Altering the mouth of a hydrophobic pocket. structure and kinetics of human carbonic anhydrase II… | x-ray diffraction | A | — | — |
| 12CA | Altering the mouth of a hydrophobic pocket. structure and kinetics of human carbonic anhydrase II… | x-ray diffraction | A | — | — |
| 1A42 | Human carbonic anhydrase II complexed with brinzolamide | x-ray diffraction | A | — | — |
| 1A42 | Human carbonic anhydrase II complexed with brinzolamide | x-ray diffraction | A | — | — |
| 1AM6 | Carbonic anhydrase II inhibitor: acetohydroxamate | x-ray diffraction | A | — | — |
| 1AM6 | Carbonic anhydrase II inhibitor: acetohydroxamate | x-ray diffraction | A | — | — |
| 1AVN | Human carbonic anhydrase II complexed with the histamine activator | x-ray diffraction | A | — | — |
| 1AVN | Human carbonic anhydrase II complexed with the histamine activator | x-ray diffraction | A | — | — |
| 1BCD | X-ray crystallographic structure of a complex between human carbonic anhydrase II and a new topical… | x-ray diffraction | A | — | — |
| 1BCD | X-ray crystallographic structure of a complex between human carbonic anhydrase II and a new topical… | x-ray diffraction | A | — | — |
| 1BIC | Crystallographic analysis of thr-200-> his human carbonic anhydrase II and its complex with the… | x-ray diffraction | A | — | — |
| 1BIC | Crystallographic analysis of thr-200-> his human carbonic anhydrase II and its complex with the… | x-ray diffraction | A | — | — |
| 1BN1 | Carbonic anhydrase II inhibitor | x-ray diffraction | A | — | — |
| 1BN1 | Carbonic anhydrase II inhibitor | x-ray diffraction | A | — | — |
| 1BN3 | Carbonic anhydrase II inhibitor | x-ray diffraction | A | — | — |
| 1BN3 | Carbonic anhydrase II inhibitor | x-ray diffraction | A | — | — |
| 1BN4 | Carbonic anhydrase II inhibitor | x-ray diffraction | A | — | — |
| 1BN4 | Carbonic anhydrase II inhibitor | x-ray diffraction | A | — | — |
| 1BNM | Carbonic anhydrase II inhibitor | x-ray diffraction | A | — | — |
| 1BNM | Carbonic anhydrase II inhibitor | x-ray diffraction | A | — | — |
| 1BNN | Carbonic anhydrase II inhibitor | x-ray diffraction | A | — | — |
| 1BNN | Carbonic anhydrase II inhibitor | x-ray diffraction | A | — | — |
| 1BNQ | Carbonic anhydrase II inhibitor | x-ray diffraction | A | — | — |
| 1BNQ | Carbonic anhydrase II inhibitor | x-ray diffraction | A | — | — |
| 1BNT | Carbonic anhydrase II inhibitor | x-ray diffraction | A | — | — |
| 1BNT | Carbonic anhydrase II inhibitor | x-ray diffraction | A | — | — |
| 1BNU | Carbonic anhydrase II inhibitor | x-ray diffraction | A | — | — |
| 1BNU | Carbonic anhydrase II inhibitor | x-ray diffraction | A | — | — |
| 1BNV | Carbonic anhydrase II inhibitor | x-ray diffraction | A | — | — |
| 1BNV | Carbonic anhydrase II inhibitor | x-ray diffraction | A | — | — |
| 1BNW | Carbonic anhydrase II inhibitor | x-ray diffraction | A | — | — |
| 1BNW | Carbonic anhydrase II inhibitor | x-ray diffraction | A | — | — |
| 1BV3 | Human carbonic anhydrase II complexed with urea | x-ray diffraction | A | — | — |
| 1BV3 | Human carbonic anhydrase II complexed with urea | x-ray diffraction | A | — | — |
| 1CA2 | Refined structure of human carbonic anhydrase II at 2.0 ångströms resolution | x-ray diffraction | A | — | — |
| 1CA2 | Refined structure of human carbonic anhydrase II at 2.0 ångströms resolution | x-ray diffraction | A | — | — |
| 1CA3 | Unexpected pH-dependent conformation of his-64, the proton shuttle of carbonic anhydrase II. | x-ray diffraction | A | — | — |
| 1CA3 | Unexpected pH-dependent conformation of his-64, the proton shuttle of carbonic anhydrase II. | x-ray diffraction | A | — | — |
| 1CAH | Structure of cobalt carbonic anhydrase complexed with bicarbonate | x-ray diffraction | A | — | — |
| 1CAH | Structure of cobalt carbonic anhydrase complexed with bicarbonate | x-ray diffraction | A | — | — |
| 1CAI | Structural analysis of the zinc hydroxide-thr 199-glu 106 hydrogen bonding network in human… | x-ray diffraction | A | — | — |
| 1CAI | Structural analysis of the zinc hydroxide-thr 199-glu 106 hydrogen bonding network in human… | x-ray diffraction | A | — | — |
| 1CAJ | Structural analysis of the zinc hydroxide-thr 199-glu 106 hydrogen bonding network in human… | x-ray diffraction | A | — | — |
| 1CAJ | Structural analysis of the zinc hydroxide-thr 199-glu 106 hydrogen bonding network in human… | x-ray diffraction | A | — | — |
| 1CAK | Structural analysis of the zinc hydroxide-thr 199-glu 106 hydrogen bonding network in human… | x-ray diffraction | A | — | — |
| 1CAK | Structural analysis of the zinc hydroxide-thr 199-glu 106 hydrogen bonding network in human… | x-ray diffraction | A | — | — |
| 1CAL | Structural analysis of the zinc hydroxide-thr 199-glu 106 hydrogen bonding network in human… | x-ray diffraction | A | — | — |
| 1CAL | Structural analysis of the zinc hydroxide-thr 199-glu 106 hydrogen bonding network in human… | x-ray diffraction | A | — | — |
| 1CAM | Structural analysis of the zinc hydroxide-thr 199-glu 106 hydrogen bonding network in human… | x-ray diffraction | A | — | — |
| 1CAM | Structural analysis of the zinc hydroxide-thr 199-glu 106 hydrogen bonding network in human… | x-ray diffraction | A | — | — |
| 1CAN | Crystallographic studies of the binding of protonated and unprotonated inhibitors to carbonic… | x-ray diffraction | A | — | — |
| 1CAN | Crystallographic studies of the binding of protonated and unprotonated inhibitors to carbonic… | x-ray diffraction | A | — | — |
| 1CAO | Crystallographic studies of the binding of protonated and unprotonated inhibitors to carbonic… | x-ray diffraction | A | — | — |
| 1CAO | Crystallographic studies of the binding of protonated and unprotonated inhibitors to carbonic… | x-ray diffraction | A | — | — |
| 1CAY | Wild-type and E106Q mutant carbonic anhydrase complexed with acetate | x-ray diffraction | A | — | — |
| 1CAY | Wild-type and E106Q mutant carbonic anhydrase complexed with acetate | x-ray diffraction | A | — | — |
| 1CAZ | Wild-type and E106Q mutant carbonic anhydrase complexed with acetate | x-ray diffraction | A | — | — |
| 1CAZ | Wild-type and E106Q mutant carbonic anhydrase complexed with acetate | x-ray diffraction | A | — | — |
| 1CCS | Structure-assisted redesign of a protein-zinc binding site with femtomolar affinity | x-ray diffraction | A | — | — |
| 1CCS | Structure-assisted redesign of a protein-zinc binding site with femtomolar affinity | x-ray diffraction | A | — | — |
1,705 records more on the page itself.
Ligands
- ZN · Zinc ion · in 575 records
- HG · Mercury (II) ion · in 66 records
- BE7 · (4-carboxyphenyl)(chloro)mercury · in 51 records
- NA · Sodium ion · in 46 records
- BGC · beta-D-glucopyranose · in 39 records
- GLC · alpha-D-glucopyranose · in 28 records
- BCN · Bicine · in 27 records
- CO2 · Carbon dioxide · in 26 records
- MBO · Mercuribenzoic acid · in 21 records
- SO4 · Sulfate ion · in 18 records
- BCT · Bicarbonate ion · in 10 records
- NI · Nickel (II) ion · in 9 records
- 6H0 · ~{N}-[[3-(4-formamidobutoxy)phenyl]methyl]-4-sulfamoyl-benzamide · in 8 records
- EVF · 1,3-benzothiazole-2-sulfonamide · in 8 records
- QVE · 8-azanyl-4-(2-hydroxy-2-oxoethyloxy)quinoline-2-carboxylic acid · in 8 records
- BEZ · Benzoic acid · in 6 records
- QUK · 8-azanyl-4-(3-azanylpropoxy)quinoline-2-carboxylic acid · in 6 records
- QVS · 8-azanyl-4-oxidanyl-quinoline-2-carboxylic acid · in 6 records
- CU · Copper (II) ion · in 5 records
- HGB · 4-(hydroxymercury)benzoic acid · in 5 records
- PX7 · 4-methyl-1lambda~6~,2,4-benzothiadiazine-1,1,3(2H,4H)-trione · in 5 records
- 7Q1 · (5R)-5-phenyl-1,3-oxazolidine-2,4-dione · in 4 records
- 8JS · 4-{[(4-fluorophenyl)carbamothioyl]amino}benzene-1-sulfonamide · in 4 records
- CL · Chloride ion · in 4 records
- CO · Cobalt (II) ion · in 4 records
- FB2 · benzenesulfonamide · in 4 records
- J3V · 4-hydroxy-3-nitro-5-({[4-(trifluoromethyl) phenyl]carbamoyl}amino)benzene-1-sulfonamide · in 4 records
- N84 · 4-hydroxy-3-({[(pyridin-4-yl)methyl]carbamoyl}amino) benzene-1-sulfonamide · in 4 records
- N8A · 4-hydroxy-3-({[2-(pyridin-2-yl)ethyl]carbamoyl}amino) benzene-1-sulfonamide · in 4 records
- Q71 · 7-fluoro-1lambda~6~,2,4-benzothiadiazine-1,1,3(2H,4H)-trione · in 4 records
Experiment against prediction
- 6EEH chain A against the predicted model P00918: TM-score 1.00, RMSD 0.31 Å
- 6OUI chain A against the predicted model P00918: TM-score 1.00, RMSD 0.31 Å
- 6OUI chain A against the predicted model P00918: TM-score 1.00, RMSD 0.31 Å
- 6EEO chain A against the predicted model P00918: TM-score 1.00, RMSD 0.31 Å
- 4M2U chain A against the predicted model P00918: TM-score 1.00, RMSD 0.31 Å
- 4M2U chain A against the predicted model P00918: TM-score 1.00, RMSD 0.31 Å
- 6BC9 chain A against the predicted model P00918: TM-score 1.00, RMSD 0.32 Å
- 6OTK chain A against the predicted model P00918: TM-score 1.00, RMSD 0.32 Å
- 6EEA chain A against the predicted model P00918: TM-score 1.00, RMSD 0.32 Å
- 6E8P chain A against the predicted model P00918: TM-score 1.00, RMSD 0.32 Å
Elsewhere
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