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Ligand · HSM

HSM · Histamine

HSM, Histamine (C5 H9 N3, 111.2 g/mol), in the MolNFT structures on GenesisL1: bound in 26 records (20 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
HSM
Formula
C5 H9 N3
Class
ligand
Structures
26
PDB entries
20

Binding sites

HSM in 26 structures; the first of them:

  • 4XMF · Crystal structure of nitrophorin 7 from Rhodnius prolixus at pH 7.8 complexed with… · HSM A202 · binds ASP32, HIS60, LEU125, GLY133, ASP134, LEU135
  • 5RUS · PanDDA analysis group deposition -- Crystal structure of SARS-CoV-2 NSP3 macrodomain in… · HSM A201 · binds ASP22, GLY48, VAL49, ALA52, PHE156
  • 6DYN · C-terminal condensation domain of Ebony in complex with Histamine · HSM A901 · binds PHE689, LEU695, GLU696, VAL760, LEU764, SER786, PHE787, THR825 and 2 more
  • 6QFA · CryoEM structure of a beta3K279T GABA(A)R homomer in complex with histamine and megabody… · HSM B502 · binds TYR97, GLU155, SER156, TYR157, PHE200, THR202, TYR205, ASP43 and 2 more
  • 7PC0 · GABA-A receptor bound by a-Cobratoxin · HSM B601 · binds ASP43, TYR62, GLN64, TYR97, TYR157, PHE200, ALA201, THR202 and 1 more
  • 7QN7 · Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex… · HSM C503 · binds ASP43, TYR62, GLN64, TYR97, GLU155, SER156, TYR157, PHE200 and 2 more
  • 7QN8 · Cryo-EM structure of human full-length beta3delta GABA(A)R in complex with histamine and… · HSM B501 · binds ASP43, TYR62, GLN64, TYR97, GLU155, SER156, TYR157, PHE200 and 3 more
  • 7QN9 · Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex… · HSM B501 · binds PHE98, ARG100, LEU151, THR163, TYR97, GLU155, SER156, TYR157 and 3 more
  • 7YFC · Cryo-EM structure of the histamine-bound histamine H4 receptor and Gq complex · HSM R601 · binds ASP94, TYR95, CYS98, GLU182, TRP316, TYR319, PHE344, GLN347 and 1 more
  • 8HN8 · Cryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complex · HSM R401 · binds ASP94, TYR95, CYS98, GLU182, TRP316, PHE344, GLN347, TRP348
  • 8JT5 · VMAT2 complex with histamine · HSM A501 · binds LEU228, ASN305, ILE308, TYR341, ILE395, ASP399, PHE429, TYR433
  • 8JXT · Histamine-bound H4R/Gi complex · HSM R401 · binds ASP94, TYR95, CYS98, TYR319, PHE344, GLN347, TRP348
  • 8UCN · Komagataella pastoris Cytochrome c oxidase in complex with human VMAT2 and Histamine · HSM A601 · binds ALA229, ILE308, GLU312, PHE334, SER338, TYR341, TYR433
  • 8YN4 · Cryo-EM structure of histamine H2 receptor in complex with histamine and miniGq · HSM R701 · binds ASP98, VAL99, CYS102, THR103, ASP186, TRP247, TYR250, PHE251 and 3 more
  • 8YUU · Cryo-EM structure of the histamine-bound H3R-Gi complex · HSM R501 · binds ASP114, TYR115, CYS118, GLU206, TYR374, PHE398, LEU401, TRP402
  • 5RUS · Pandda analysis group deposition -- crystal structure of SARS-cov-2 NSP3 macrodomain in… · HSM A201 · binds ASP22, GLY48, VAL49, ALA52, PHE156
  • 6DYN · C-terminal condensation domain of ebony in complex with histamine · HSM A901 · binds PHE689, GLU696, VAL760, LEU764, PHE787, THR826, THR828
  • 6FU4 · Ligand binding domain (lbd) of the P. aeruginosa histamine receptor tlpq · HSM A401 · binds TYR126, TYR158, GLU170, MSE172, GLU176, TYR189, TRP192, TYR208 and 3 more
  • 6QFA · Cryoem structure of a BETA3K279T GABA(A)R homomer in complex with histamine and megabody… · HSM B502 · binds TYR97, GLU155, SER156, TYR157, PHE200, THR202, TYR205, ASP43 and 1 more
  • 7A5V · Cryoem structure of a human gamma-aminobutyric acid receptor, the GABA(A)R-BETA3… · HSM A5408 · binds TYR97, GLU155, SER156, TYR157, PHE200, TYR205
  • 7DFL · Cryo-EM structure of histamine H1 receptor gq complex · HSM R900 · binds ASP107, TYR108, SER111, THR112, ASN198, TYR431, PHE432, ILE454 and 1 more
  • 7QN7 · Cryo-EM structure of human full-length extrasynaptic ALPHA4BETA3DELTA GABA(A)R in complex… · HSM C503 · binds ASP43, TYR62, GLN64, TYR97, GLU155, SER156, TYR157, PHE200 and 2 more
  • 7QN8 · Cryo-EM structure of human full-length BETA3DELTA GABA(A)R in complex with histamine and… · HSM B501 · binds ASP43, TYR62, GLN64, TYR97, GLU155, SER156, TYR157, PHE200 and 2 more

Residues it binds most

TYR 45, ASP 44, PHE 45, GLU 41, THR 36, SER 35, GLN 26, TRP 9, LEU 8, MSE 4 (residue and the binding sites it lines).

Found with

  • BMA · beta-D-mannopyranose
  • MAN · alpha-D-mannopyranose
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • D10 · Decane
  • R16 · Hexadecane
  • CLR · Cholesterol
  • ABU · Gamma-amino-butanoic acid
  • EI7 · 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-3-one
  • PX6 · 1,2-dipalmitoyl-sn-glycero-3-phosphate
  • CA · Calcium ion
  • ZN · Zinc ion
  • PO4 · Phosphate ion

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