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Ligand · EZL

EZL · 6-ethoxy-1,3-benzothiazole-2-sulfonamide

EZL, 6-ethoxy-1,3-benzothiazole-2-sulfonamide (C9 H10 N2 O3 S2, 258.3 g/mol), in the MolNFT structures on GenesisL1: bound in 9 records (5 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…

Component
EZL
Formula
C9 H10 N2 O3 S2
Class
ligand
Structures
9
PDB entries
5

Binding sites

EZL in 9 structures; the first of them:

  • 5JN9 · Crystal structure for the complex of human carbonic anhydrase IV and ethoxyzolamide · EZL A302 · binds GLN92, HIS94, HIS96, GLU106, HIS119, VAL121, VAL143, SER197 and 5 more
  • 5TT3 · Crystal structure of the complex of Helicobacter pylori alpha-carbonic anhydrase with… · EZL A303 · binds HIS110, HIS112, GLU116, HIS129, VAL131, VAL141, LEU190, THR191 and 4 more
  • 6BCC · Joint X-ray/neutron structure of human carbonic anhydrase II in complex with ethoxzolamide · EZL A302 · binds GLN92, HIS94, HIS96, GLU106, HIS119, VAL121, PHE131, VAL135 and 8 more
  • 6MWI · Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF)… · EZL B202 · binds ASP10, HIS12, HIS44, ILE59, PHE63, SER64, ASP65, PHE70 and 1 more
  • 6QL2 · Crystal structure of chimeric carbonic anhydrase VI with ethoxzolamide. · EZL A306 · binds GLN92, HIS94, HIS96, GLU106, HIS119, VAL121, TYR131, GLN135 and 8 more
  • 5TT3 · Crystal structure of the complex of helicobacter pylori alpha-carbonic anhydrase with… · EZL A303 · binds HIS110, HIS112, HIS129, VAL131, VAL141, LEU190, THR191, ALA192 and 3 more
  • 6BCC · Joint X-RAY/NEUTRON structure of human carbonic anhydrase II in complex with ethoxzolamide · EZL A302 · binds HIS94, HIS96, HIS119, VAL121, PHE131, VAL143, SER197, LEU198 and 5 more
  • 6MWI · Crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispf)… · EZL B202 · binds ASP10, HIS12, HIS44, ILE59, PHE63, SER64, ASP65, PHE70 and 1 more
  • 6QL2 · Crystal structure of chimeric carbonic anhydrase VI with ethoxzolamide. · EZL A306 · binds HIS94, HIS96, HIS119, VAL121, TYR131, GLN135, VAL143, LEU198 and 5 more

Residues it binds most

HIS 24, VAL 22, PRO 22, THR 22, LEU 22, TRP 22, ALA 14, SER 13, GLU 11, GLN 7 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • DMS · Dimethyl sulfoxide
  • ACT · Acetate ion
  • GOL · Glycerol
  • BCN · Bicine
  • CL · Chloride ion
  • EDO · 1,2-ethanediol
  • MES · 2-(N-morpholino)-ethanesulfonic acid
  • PEG · Di(hydroxyethyl)ether
  • SO4 · Sulfate ion

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