UniProt O59010
Glutamate transporter homolog (O59010)
Glutamate transporter homolog (UniProt O59010): 61 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 218 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O59010
- Protein
- Glutamate transporter homolog
- Experimental structures
- 61
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 218 · 19 records with a druggable one
Structures
62 records of O59010 in the MolNFT archive: 61 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1XFH | Structure of glutamate transporter homolog from Pyrococcus horikoshii | x-ray diffraction | A, B, C | — | — |
| 1XFH | Structure of glutamate transporter homolog from pyrococcus horikoshii | x-ray diffraction | A, B, C | — | — |
| 2NWL | Crystal structure of GltPh in complex with L-Asp | x-ray diffraction | A, B, C | — | — |
| 2NWL | Crystal structure of gltph in complex with L-asp | x-ray diffraction | A, B, C | — | — |
| 2NWW | Crystal structure of GltPh in complex with TBOA | x-ray diffraction | A, B, C | — | — |
| 2NWW | Crystal structure of gltph in complex with tboa | x-ray diffraction | A, B, C | — | — |
| 2NWX | Crystal structure of GltPh in complex with L-aspartate and sodium ions | x-ray diffraction | A, B, C | — | — |
| 2NWX | Crystal structure of gltph in complex with L-aspartate and sodium ions | x-ray diffraction | A, B, C | — | — |
| 3KBC | Crystal structure of GltPh K55C-A364C mutant crosslinked with divalent mercury | x-ray diffraction | A, B, C | — | — |
| 3KBC | Crystal structure of gltph K55C-A364C mutant crosslinked with divalent mercury | x-ray diffraction | A, B, C | — | — |
| 3V8F | Crystal structure of crosslinked GltPh V216C-M385C mutant | x-ray diffraction | A, B, C | — | — |
| 3V8F | Crystal structure of crosslinked gltph V216C-M385C mutant | x-ray diffraction | A, B, C | — | — |
| 3V8G | Crystal structure of an asymmetric trimer of a glutamate transporter homologue (GltPh) | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3V8G | Crystal structure of an asymmetric trimer of a glutamate transporter homologue (gltph) | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4IZM | Crystal structure of GltPh L66C-S300C mutant crosslinked with divalent mercury | x-ray diffraction | A, B, C | — | — |
| 4IZM | Crystal structure of gltph L66C-S300C mutant crosslinked with divalent mercury | x-ray diffraction | A, B, C | — | — |
| 4OYE | Crystal structure of GltPh R397A in apo | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4OYE | Crystal structure of gltph R397A in apo | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L | — | — |
| 4P19 | Closed, apo inward-facing state of the glutamate transporter homologue GltPh | x-ray diffraction | A, B, C | — | — |
| 4P19 | Closed, apo inward-facing state of the glutamate transporter homologue gltph | x-ray diffraction | A, B, C | — | — |
| 4P1A | Thallium-bound inward-facing state of the glutamate transporter homologue GltPh | x-ray diffraction | A, B, C | — | — |
| 4P1A | Thallium-bound inward-facing state of the glutamate transporter homologue gltph | x-ray diffraction | A, B, C | — | — |
| 4P3J | Apo inward-facing state of the glutamate transporter homologue GltPh in alkali-free conditions | x-ray diffraction | A, B, C | — | — |
| 4P3J | Apo inward-facing state of the glutamate transporter homologue gltph in alkali-free conditions | x-ray diffraction | A, B, C | — | — |
| 4P6H | Tl+-bound inward-facing state (bound conformation) of the glutamate transporter homologue GltPh | x-ray diffraction | A, B, C | — | — |
| 4P6H | Tl+-bound inward-facing state (bound conformation) of the glutamate transporter homologue gltph | x-ray diffraction | A, B, C | — | — |
| 4X2S | Crystal structure of 276S/M395R-gltph in inward-facing conformation | x-ray diffraction | A, B, C | — | — |
| 5CFY | Crystal structure of gltph R397A in complex with na+ and L-asp | x-ray diffraction | A, B, C, D, E, F | — | — |
| 6BAT | Crystal Structure of Wild-Type GltPh in complex with L-aspartate | x-ray diffraction | A, B, C | NA, ASP | 19 (best 0.88) |
| 6BAT | Crystal structure of wild-type gltph in complex with L-aspartate | x-ray diffraction | A, B, C | NA | — |
| 6BAU | Crystal Structure of GltPh R397C in complex with L-Cysteine | x-ray diffraction | A, B, C | NA, CYS | 20 (best 0.88) |
| 6BAU | Crystal structure of gltph R397C in complex with L-cysteine | x-ray diffraction | A, B, C | NA | — |
| 6BAV | Crystal Structure of GltPh R397C in complex with S-Benzyl-L-Cysteine | x-ray diffraction | A, B, C | NA, BCS | 17 (best 0.88) |
| 6BAV | Crystal structure of gltph R397C in complex with S-benzyl-L-cysteine | x-ray diffraction | A, B, C | NA | — |
| 6BMI | Crystal Structure of GltPh R397C in complex with L-Serine | x-ray diffraction | A, B, C | NA | — |
| 6BMI | Crystal structure of gltph R397C in complex with L-serine | x-ray diffraction | A, B, C | NA | — |
| 6CTF | Crystal structure of GltPh fast mutant - R276S/M395R | x-ray diffraction | A, B, C | ASP, NA | 18 (best 0.87) |
| 6CTF | Crystal structure of gltph fast mutant - R276S/M395R | x-ray diffraction | A, B, C | NA | — |
| 6V8G | GltPh mutant - Y204L A345V V366A | x-ray diffraction | A, B, C | NA, ASP | 16 (best 0.88) |
| 6V8G | Gltph mutant - Y204L A345V V366A | x-ray diffraction | A, B, C | NA | — |
| 6WYJ | Cryo-EM structure of the GltPh L152C-G321C mutant in the intermediate state | electron microscopy | A | ASP | 7 (best 0.68) |
| 6WYJ | Cryo-EM structure of the gltph L152C-G321C mutant in the intermediate state | electron microscopy | A | — | — |
| 6WYK | Cryo-EM structure of the GltPh L152C-G321C mutant in the intermediate chloride conducting state. | electron microscopy | A | ASP | 7 (best 0.71) |
| 6WYK | Cryo-EM structure of the gltph L152C-G321C mutant in the intermediate chloride conducting state. | electron microscopy | A | — | — |
| 6WYL | Cryo-EM structure of GltPh L152C-G351C mutant in the intermediate outward-facing state. | electron microscopy | A, B, C | ASP | 20 (best 0.86) |
| 6WYL | Cryo-EM structure of gltph L152C-G351C mutant in the intermediate outward-facing state. | electron microscopy | A, B, C | — | — |
| 6WZB | Crystal structure of the GltPh V216C-G388C mutant cross-linked with divalent mercury | x-ray diffraction | A, B, C | ASP, NA, HG | 20 (best 0.88) |
| 6WZB | Crystal structure of the gltph V216C-G388C mutant cross-linked with divalent mercury | x-ray diffraction | A, B, C | NA, HG | — |
| 6X01 | Crystal structure of the GltPh V216C-A391C mutant cross-linked in outward-facing state | x-ray diffraction | A, B, C | ASP, NA | 15 (best 0.89) |
| 6X01 | Crystal structure of the gltph V216C-A391C mutant cross-linked in outward-facing state | x-ray diffraction | A, B, C | NA | — |
| 7AHK | Crystal structure of the outward-facing state of the substrate-free Na+-only bound glutamate… | x-ray diffraction | A | NA, PO4, LFA | 3 (best 0.60) |
| 7AHK | Crystal structure of the outward-facing state of the substrate-free na+-only bound glutamate… | x-ray diffraction | A | NA, PO4, LFA | — |
| 7RCP | GltPh mutant (S279E/D405N) in complex with aspartate and sodium ions | electron microscopy | A, B, C | ASP, NA | 14 (best 0.88) |
| 7RCP | Gltph mutant (S279E/D405N) in complex with aspartate and sodium ions | electron microscopy | A, B, C | NA | — |
| 7UG0 | TBOA-bound GltPh RSMR mutant in IFS state | electron microscopy | A | TB1, NA | 7 (best 0.73) |
| 7UGD | Asp-bound GltPh RSMR mutant in IFS-A1 state | electron microscopy | A | ASP, NA | 5 (best 0.54) |
| 7UGJ | TBOA-bound GltPh RSMR mutant in OFS state | electron microscopy | A | TB1, NA | 5 (best 0.59) |
| 7UGV | Asp-bound GltPh RSMR mutant in IFS-A2 state | electron microscopy | A | ASP, NA | 9 (best 0.55) |
| 7UGX | Asp-bound GltPh RSMR mutant in IFS-B1 state | electron microscopy | A | ASP, NA | 4 (best 0.76) |
| 7UH3 | Asp-bound GltPh RSMR mutant in iOFS state | electron microscopy | A | ASP, NA | 8 (best 0.59) |
2 records more on the page itself.
Ligands
Experiment against prediction
- 6V8G chain B against the predicted model O59010: TM-score 0.98, RMSD 0.90 Å
- 6V8G chain C against the predicted model O59010: TM-score 0.98, RMSD 0.90 Å
- 6V8G chain A against the predicted model O59010: TM-score 0.98, RMSD 0.90 Å
- 6V8G chain B against the predicted model O59010: TM-score 0.98, RMSD 0.90 Å
- 6V8G chain C against the predicted model O59010: TM-score 0.98, RMSD 0.90 Å
- 6V8G chain A against the predicted model O59010: TM-score 0.98, RMSD 0.90 Å
- 5CFY chain A against the predicted model O59010: TM-score 0.97, RMSD 1.17 Å
- 2NWX chain B against the predicted model O59010: TM-score 0.97, RMSD 1.47 Å
- 2NWX chain B against the predicted model O59010: TM-score 0.97, RMSD 1.47 Å
- 2NWL chain B against the predicted model O59010: TM-score 0.97, RMSD 1.35 Å
Elsewhere
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