MolNFT v1 · #169058 · protein
Crystal structure of the gltph V216C-G388C mutant cross-linked with divalent mercury
6WZB · Glutamate transporter homolog: “Crystal structure of the gltph V216C-G388C mutant cross-linked with divalent mercury”. X-ray diffraction, 3 ligands (ASP, NA, HG), 20 pockets (best druggability 0.88). MolNFT v1 #169058 on GenesisL1…
- PDB
- 6WZB
- Type
- protein
- Length
- 1,233 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate transporter homolog
- UniProt
- O59010
- Ligands
- ASP, NA, HG
- Pockets
- 20 · best druggability 0.88
Structure
x-ray diffraction · 1 distinct chain · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Glutamate transporter homolog | protein | 411 | 77% helix, 0% strand | O59010 |
Ligands and binding sites
- ASP · Aspartic acid · ligand · 3 copies · chains A, B, C
- NA · Sodium ion · metal · 6 copies · chains A, B, C
- HG · Mercury (II) ion · metal · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 581 | 0.88 | 0.93 | 54 | empty |
| 2 | 486 | 0.68 | 0.79 | 67 | empty |
| 3 | 565 | 0.67 | 0.77 | 54 | empty |
| 4 | 496 | 0.66 | 0.78 | 42 | empty |
| 5 | 220 | 0.66 | 0.84 | 33 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1137 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 1125 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 1116 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 6WZB · Crystal structure of the GltPh V216C-G388C mutant cross-linked with divalent mercury · the same entry in another collection · chain A against A, TM-score 1.00
- O59010 · AlphaFold monomer V2.0 prediction for glutamate transporter homolog (O59010) · a predicted model of the same protein · chain C against A, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O59010
- Elsewhere: RCSB PDB 6WZB · PDBe 6WZB · UniProt O59010
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.