MolNFT v1 · #169032 · protein
Cryo-EM structure of gltph L152C-G351C mutant in the intermediate outward-facing state.
6WYL · Glutamate transporter homolog: “Cryo-EM structure of gltph L152C-G351C mutant in the intermediate outward-facing state.”. Electron microscopy, 1 ligand (ASP), 20 pockets (best druggability 0.86). MolNFT v1 #169032 on GenesisL1: 3D…
- PDB
- 6WYL
- Type
- protein
- Length
- 1,191 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate transporter homolog
- UniProt
- O59010
- Ligands
- ASP
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 1 distinct chain · 83% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Glutamate transporter homolog | protein | 397 | 83% helix, 0% strand | O59010 |
Ligands and binding sites
- ASP · Aspartic acid · ligand · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 882 | 0.86 | 0.87 | 64 | empty |
| 2 | 586 | 0.66 | 0.76 | 64 | empty |
| 3 | 51 | 0.65 | 0.95 | 17 | empty |
| 4 | 51 | 0.64 | 0.95 | 18 | empty |
| 5 | 463 | 0.63 | 0.76 | 49 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1083 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 1075 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 1069 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6WYL · Cryo-EM structure of GltPh L152C-G351C mutant in the intermediate outward-facing state. · the same entry in another collection · chain A against A, TM-score 1.00
- O59010 · AlphaFold monomer V2.0 prediction for glutamate transporter homolog (O59010) · a predicted model of the same protein · chain C against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O59010
- Elsewhere: RCSB PDB 6WYL · PDBe 6WYL · UniProt O59010
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.