MolNFT v1 · #167024 · protein

Gltph mutant - Y204L A345V V366A

6V8G · Glutamate transporter homolog: “Gltph mutant - Y204L A345V V366A”. X-ray diffraction, 2 ligands (ASP, NA), 16 pockets (best druggability 0.88). MolNFT v1 #167024 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6V8G
Type: protein
Length: 1,179 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutamate transporter homolog
UniProt: O59010
Ligands: ASP, NA
Pockets: 16 · best druggability 0.88

Structure

x-ray diffraction · 1 distinct chain · 81% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Glutamate transporter homolog	protein	393	81% helix, 0% strand	O59010

Ligands and binding sites

ASP · Aspartic acid · ligand · 3 copies · chains A, B, C
NA · Sodium ion · metal · 9 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

16 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	553	0.88	0.93	38	empty
2	247	0.51	0.74	32	empty
3	262	0.51	0.73	34	empty
4	277	0.50	0.73	45	empty
5	157	0.42	0.74	27	empty

Interfaces

3 interfaces between chains.

B–C · 1094 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 1092 Å² buried · 12 hydrogen bonds · protein-protein
A–C · 1083 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

6V8G · GltPh mutant - Y204L A345V V366A · the same entry in another collection · chain A against A, TM-score 1.00
O59010 · AlphaFold monomer V2.0 prediction for glutamate transporter homolog (O59010) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O59010
Elsewhere: RCSB PDB 6V8G · PDBe 6V8G · UniProt O59010

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