MolNFT v1 · #102845 · protein
Crystal structure of gltph R397A in apo
4OYE · 425AA long hypothetical proton glutamate symport protein: “Crystal structure of gltph R397A in apo”. X-ray diffraction, 20 pockets (best druggability 0.88). MolNFT v1 #102845 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 4OYE
- Type
- protein
- Length
- 4,845 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 425AA long hypothetical proton glutamate symport protein
- UniProt
- O59010
- Pockets
- 20 · best druggability 0.88
Structure
x-ray diffraction · 3 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 425AA long hypothetical proton glutamate symport protein | protein | 402 | 71% helix, 0% strand | O59010 |
| B, C, D, E, F, G, H, J, K, L | 425AA long hypothetical proton glutamate symport protein | protein | 404 | 72% helix, 0% strand | O59010 |
| I | 425AA long hypothetical proton glutamate symport protein | protein | 403 | 71% helix, 0% strand | O59010 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 639 | 0.88 | 0.92 | 40 | empty |
| 2 | 648 | 0.88 | 0.92 | 41 | empty |
| 3 | 626 | 0.88 | 0.92 | 41 | empty |
| 4 | 645 | 0.88 | 0.92 | 39 | empty |
| 5 | 52 | 0.69 | 0.98 | 21 | empty |
Interfaces
21 interfaces between chains.
- A–B · 1146 Ų buried · 6 hydrogen bonds · protein-protein
- H–I · 1145 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 1144 Ų buried · 8 hydrogen bonds · protein-protein
- D–E · 1142 Ų buried · 7 hydrogen bonds · protein-protein
- J–L · 1141 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 4OYE · Crystal structure of GltPh R397A in apo · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O59010
- Elsewhere: RCSB PDB 4OYE · PDBe 4OYE · UniProt O59010
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