UniProt O43175
D-3-phosphoglycerate dehydrogenase (O43175)
D-3-phosphoglycerate dehydrogenase (UniProt O43175), EC 1.1.1.37, 1.1.1.399: 33 experimental structures on GenesisL1, 24 ligands bound, 16 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O43175
- Protein
- D-3-phosphoglycerate dehydrogenase
- EC
- 1.1.1.37, 1.1.1.399, 1.1.1.95
- Experimental structures
- 33
- Predicted models
- 0
- Ligands
- 24
- Pockets
- 16 · 1 record with a druggable one
Structures
33 records of O43175 in the MolNFT archive: 33 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2G76 | Crystal structure of human 3-phosphoglycerate dehydrogenase | x-ray diffraction | A, B | — | — |
| 2G76 | Crystal structure of human 3-phosphoglycerate dehydrogenase | x-ray diffraction | A, B | — | — |
| 5N53 | Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with… | x-ray diffraction | B, A | 8NB | 4 (best 0.43) |
| 5N53 | Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with… | x-ray diffraction | B, A | 8NB | — |
| 5N6C | Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with NAD and L-Tartrate | x-ray diffraction | A, B | NAD | 4 (best 0.66) |
| 5N6C | Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with NAD and L-tartrate | x-ray diffraction | A, B | NAD | — |
| 5NZO | Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with… | x-ray diffraction | B, A | 9EZ | — |
| 5NZP | Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-Hydroxybenzisoxazole | x-ray diffraction | B, A | 9EW | 4 (best 0.42) |
| 5NZP | Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-hydroxybenzisoxazole | x-ray diffraction | B, A | 9EW | — |
| 5NZQ | Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with… | x-ray diffraction | B, A | 5AO | — |
| 5OFM | Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with… | x-ray diffraction | B, A | 9TT | — |
| 5OFV | Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with… | x-ray diffraction | B, A | 9TZ | 4 (best 0.44) |
| 5OFV | Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with… | x-ray diffraction | B, A | 9TZ | — |
| 5OFW | Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with… | x-ray diffraction | B, A | 9TW | — |
| 5OFW | Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with… | x-ray diffraction | B, A | 9TW | — |
| 6CWA | Crystal structure phgdh in complex with NADH and 3-phosphoglycerate at 1.77 a resolution | x-ray diffraction | A, B | 3PG, NAI | — |
| 6CWA | Crystal structure phgdh in complex with NADH and 3-phosphoglycerate at 1.77 a resolution | x-ray diffraction | A, B | 3PG, NAI | — |
| 6PLF | Crystal structure of human phgdh complexed with compound 1 | x-ray diffraction | A, B | ONV | — |
| 6PLG | Crystal structure of human PHGDH complexed with Compound 15 | x-ray diffraction | A, B, C, D, E, F, G, H | ONS, MLT | — |
| 6PLG | Crystal structure of human phgdh complexed with compound 15 | x-ray diffraction | A, B, C, D, E, F, G, H | ONS, MLT | — |
| 6RIH | Crystal structure of phgdh in complex with compound 9 | x-ray diffraction | A, B | K4T, SO4 | — |
| 6RJ2 | Crystal structure of PHGDH in complex with compound 40 | x-ray diffraction | A, B | SO4, K52 | — |
| 6RJ2 | Crystal structure of phgdh in complex with compound 40 | x-ray diffraction | A, B | SO4, K52 | — |
| 6RJ3 | Crystal structure of phgdh in complex with compound 15 | x-ray diffraction | A, B | SO4, K58 | — |
| 6RJ5 | Crystal structure of phgdh in complex with compound 39 | x-ray diffraction | A, B | SO4, K5N | — |
| 6RJ6 | Crystal structure of PHGDH in complex with BI-4924 | x-ray diffraction | A, B | K5K | — |
| 6RJ6 | Crystal structure of phgdh in complex with bi-4924 | x-ray diffraction | A, B | K5K | — |
| 7CVP | The crystal structure of human phgdh from biortus. | x-ray diffraction | A, B | NAD | — |
| 7DKM | PHGDH covalently linked to oridonin | x-ray diffraction | A, B | ODN, NAD, CL, NA | — |
| 7DKM | Phgdh covalently linked to oridonin | x-ray diffraction | A, B | ODN, NAD, CL, NA | — |
| 7EWH | Crystal structure of human PHGDH in complex with Homoharringtonine | x-ray diffraction | A, B | HMT | — |
| 7VA1 | Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with GDD-04-35 | x-ray diffraction | B, A, C, D | 5YP | — |
| O43175 | AlphaFold monomer V2.0 prediction for D-3-phosphoglycerate dehydrogenase (O43175) | — | — | — |
Ligands
- NAD · Nicotinamide-adenine-dinucleotide · in 5 records
- SO4 · Sulfate ion · in 5 records
- 3PG · 3-phosphoglyceric acid · in 2 records
- 8NB · ~{N}-(3-chloranyl-4-methoxy-phenyl)ethanamide · in 2 records
- 9EW · 1,2-benzoxazol-3-ol · in 2 records
- 9TW · 3-chloranyl-4-fluoranyl-benzamide · in 2 records
- 9TZ · 5-fluoranyl-2-methyl-benzoic acid · in 2 records
- CL · Chloride ion · in 2 records
- K52 · ~{N}-[(1~{R})-1-[4-(ethanoylsulfamoyl)phenyl]ethyl]-2-methyl-5-phenyl-pyrazole-3-carboxamide · in 2 records
- K5K · 2-[4-[(1~{S})-1-[[4,5-bis(chloranyl)-1,6-dimethyl-indol-2-yl]carbonylamino]-2-oxidanyl-ethyl]phenyl]sulfonylethanoic acid · in 2 records
- MLT · D-malate · in 2 records
- NA · Sodium ion · in 2 records
- NAI · 1,4-dihydronicotinamide adenine dinucleotide · in 2 records
- ODN · (1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14r, 16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one · in 2 records
- ONS · (2S)-(4-{3-[(4,5-dichloro-1-methyl-1H-indole-2-carbonyl)amino]oxetan-3-yl}phenyl)(pyridin-3-yl)acetic acid · in 2 records
- 5AO · 3-(1,3-oxazol-5-yl)aniline · in 1 record
- 5YP · 4-[(3-ethanoylphenyl)sulfamoyl]-~{N}-[4-(3-fluorophenyl)-1,3-thiazol-2-yl]benzamide · in 1 record
- 9EZ · 2-methyl-5-phenyl-pyrazol-3-amine · in 1 record
- 9TT · 1-methylindol-5-amine · in 1 record
- HMT · (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine · in 1 record
- K4T · ~{N}-cyclopropyl-2-methyl-5-phenyl-pyrazole-3-carboxamide · in 1 record
- K58 · 4-[(1~{R})-1-[(2-methyl-5-phenyl-pyrazol-3-yl) carbonylamino]ethyl]benzoic acid · in 1 record
- K5N · 2-methyl-~{N}-[(1~{R})-1-[4-(methylsulfonylcarbamoyl) phenyl]ethyl]-5-phenyl-pyrazole-3-carboxamide · in 1 record
- ONV · 4-{(1S)-1-[(5-chloro-6-{[(5S)-2-oxo-1,3-oxazolidin-5-yl]methoxy}-1H-indole-2-carbonyl)amino]-2-hydroxyethyl}benzoic acid · in 1 record
Elsewhere
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