MolNFT v2 · #161630 · protein
Crystal structure of human PHGDH complexed with Compound 15
6PLG: “Crystal structure of human PHGDH complexed with Compound 15”. X-ray diffraction at 2.93, 2 ligands (ONS, MLT). MolNFT v2 #161630 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6PLG
- Type
- protein
- Length
- 2,418 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.93
- Source
- Homo sapiens
- UniProt
- O43175
- Ligands
- ONS, MLT
Structure
x-ray diffraction · resolution 2.93 · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, H | — | protein | 303 | — | O43175 |
| E | — | protein | 302 | — | O43175 |
| F | — | protein | 299 | — | O43175 |
| G | — | protein | 302 | — | O43175 |
Ligands and binding sites
- ONS · (2S)-(4-{3-[(4,5-dichloro-1-methyl-1H-indole-2-carbonyl)amino]oxetan-3-yl}phenyl)(pyridin-3-yl)acetic acid · ligand · 8 copies · chains A, B, D, C, E, F, G, H
- MLT · D-malate · ligand · 4 copies · chains A, E, F, C, G, D, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6PLG · Crystal structure of human phgdh complexed with compound 15 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43175
- Elsewhere: RCSB PDB 6PLG · PDBe 6PLG · UniProt O43175
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