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Ligand · ONS

ONS · (2S)-(4-{3-[(4,5-dichloro-1-methyl-1H-indole-2-carbonyl)amino]oxetan-3-yl}phenyl)(pyridin-3-yl)acetic acid

ONS, (2S)-(4-{3-[(4,5-dichloro-1-methyl-1H-indole-2-carbonyl)amino]oxetan-3-yl}phenyl)(pyridin-3-yl)acetic acid (C26 H21 Cl2 N3 O4, 510.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site…

Component
ONS
Formula
C26 H21 Cl2 N3 O4
Class
ligand
Structures
2
PDB entries
1

Binding sites

ONS in 2 structures; the first of them:

  • 6PLG · Crystal structure of human PHGDH complexed with Compound 15 · ONS A401 · binds LEU153, GLY154, ARG155, ILE156, TYR174, ASP175, PRO176, ILE177 and 8 more
  • 6PLG · Crystal structure of human phgdh complexed with compound 15 · ONS A401 · binds LEU153, GLY154, ARG155, ILE156, TYR174, ASP175, PRO176, ILE177 and 8 more

Residues it binds most

ILE 16, LEU 16, THR 16, PRO 16, ARG 16, GLY 16, ALA 16, ASP 16, HIS 16, TYR 16 (residue and the binding sites it lines).

Found with

  • MLT · D-malate

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