HMT · (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine

Binding sites

HMT in 4 structures; the first of them:

• 6QZP · High-resolution cryo-EM structure of the human 80S ribosome · HMT L55374 · binds G3904, A3905, G3907, OMC3909, G4393, A4397, C4398, U4446 and 4 more
• 7EWH · Crystal structure of human PHGDH in complex with Homoharringtonine · HMT A400 · binds ILE149, LEU150, GLY151, LEU152, GLY153, ARG154, ILE155, GLY156 and 8 more
• 8A3D · Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound · HMT A5455 · binds G3904, A3905, G3907, G4393, A4397, C4398, U4446, A4449 and 3 more
• 8UKB · In situ HHT and CHX treated human hibernating state without E-tRNA 80S ribosome · HMT L55313 · binds G3904, A3905, G3907, G4393, A4397, C4398, U4446, A4449 and 4 more

Residues it binds most

G 3, A 3, U 3, GLY 2, ILE 2, LEU 2, PRO 2, C 3, THR 2, ARG 2 (residue and the binding sites it lines).

Found with

• MG · Magnesium ion
• ZN · Zinc ion
• HYG · Hygromycin B
• SPM · Spermine
• WV3 · 4-{(2R)-2-[(1R,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione
• K · Potassium ion
• NA · Sodium ion
• EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid