MolNFT v2 · #163999 · protein

Crystal structure of PHGDH in complex with BI-4924

6RJ6: “Crystal structure of PHGDH in complex with BI-4924”. X-ray diffraction at 1.984, 1 ligand (K5K). MolNFT v2 #163999 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6RJ6
Type: protein
Length: 414 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.984
Source: Homo sapiens
UniProt: O43175
Ligands: K5K

Structure

x-ray diffraction · resolution 1.984 · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	204	—	O43175
B	—	protein	210	—	O43175

Ligands and binding sites

K5K · 2-[4-[(1~{S})-1-[[4,5-bis(chloranyl)-1,6-dimethyl-indol-2-yl]carbonylamino]-2-oxidanyl-ethyl]phenyl]sulfonylethanoic acid · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6RJ6 · Crystal structure of phgdh in complex with bi-4924 · the same entry in another collection · chain A against A, TM-score 1.00
O43175 · AlphaFold monomer V2.0 prediction for D-3-phosphoglycerate dehydrogenase (O43175) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O43175
Elsewhere: RCSB PDB 6RJ6 · PDBe 6RJ6 · UniProt O43175

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