UniProt O14745
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (O14745)
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (UniProt O14745), EC 5.6.1.6: 40 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 48 pockets. Binding sites, druggability and experiment against…
- UniProt
- O14745
- Protein
- Na(+)/H(+) exchange regulatory cofactor NHE-RF1
- EC
- 5.6.1.6
- Experimental structures
- 40
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 48 · 5 records with a druggable one
Structures
41 records of O14745 in the MolNFT archive: 40 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1G9O | First PDZ domain of the human NA+/H+ exchanger regulatory factor | x-ray diffraction | A | — | 1 (best 0.38) |
| 1G9O | First PDZ domain of the human NA+/H+ exchanger regulatory factor | x-ray diffraction | A | — | 1 (best 0.38) |
| 1GQ4 | Structural determinants of the nherf interaction with BETA2AR and pdgfr | x-ray diffraction | A | CL | 1 (best 0.34) |
| 1GQ4 | Structural determinants of the nherf interaction with BETA2AR and pdgfr | x-ray diffraction | A | CL | 1 (best 0.34) |
| 1GQ5 | Structural Determinants of the NHERF Interaction with beta2-AR and PDGFR | x-ray diffraction | A | CL | 1 (best 0.35) |
| 1GQ5 | Structural determinants of the nherf interaction with BETA2-ar and pdgfr | x-ray diffraction | A | CL | 1 (best 0.35) |
| 1I92 | Structural basis of the nherf PDZ1-cftr interaction | x-ray diffraction | A | CL | 1 (best 0.32) |
| 1I92 | Structural basis of the nherf PDZ1-cftr interaction | x-ray diffraction | A | — | — |
| 1SGH | Moesin FERM domain bound to EBP50 C-terminal peptide | x-ray diffraction | B | — | 3 (best 0.57) |
| 1SGH | Moesin ferm domain bound to EBP50 C-terminal peptide | x-ray diffraction | B | — | 3 (best 0.57) |
| 2D10 | Crystal structure of the Radixin FERM domain complexed with the NHERF-1 C-terminal tail peptide | x-ray diffraction | E, F, G, H | — | — |
| 2D10 | Crystal structure of the radixin ferm domain complexed with the nherf-1 C-terminal tail peptide | x-ray diffraction | E, F, G, H | — | 5 (best 0.63) |
| 2JXO | Structure of the second PDZ domain of NHERF-1 | solution nmr | A | — | — |
| 2JXO | Structure of the second PDZ domain of nherf-1 | solution nmr | A | — | — |
| 2KJD | Solution structure of extended PDZ2 domain from NHERF1 (150-270) | solution nmr | A | — | — |
| 2KJD | Solution structure of extended PDZ2 domain from NHERF1 (150-270) | solution nmr | A | — | — |
| 2KRG | Solution Structure of human sodium/ hydrogen exchange regulatory factor 1(150-358) | solution nmr | A | — | 2 (best 0.52) |
| 2KRG | Solution structure of human sodium/ hydrogen exchange regulatory factor 1(150-358) | solution nmr | A | — | 2 (best 0.52) |
| 2M0T | Structural characterization of the extended PDZ1 domain from NHERF1 | solution nmr | A | — | — |
| 2M0T | Structural characterization of the extended PDZ1 domain from NHERF1 | solution nmr | A | — | — |
| 2M0U | Complex structure of C-terminal CFTR peptide and extended PDZ1 domain from NHERF1 | solution nmr | A | — | 1 (best 0.44) |
| 2M0U | Complex structure of C-terminal cftr peptide and extended PDZ1 domain from NHERF1 | solution nmr | A | — | 1 (best 0.44) |
| 2M0V | Complex structure of C-terminal CFTR peptide and extended PDZ2 domain from NHERF1 | solution nmr | A | — | 1 (best 0.41) |
| 2M0V | Complex structure of C-terminal cftr peptide and extended PDZ2 domain from NHERF1 | solution nmr | A | — | 1 (best 0.41) |
| 2OZF | The crystal structure of the 2nd PDZ domain of the human NHERF-1 (SLC9A3R1) | x-ray diffraction | A | — | 1 (best 0.31) |
| 2OZF | The crystal structure of the 2ND PDZ domain of the human nherf-1 (SLC9A3R1) | x-ray diffraction | A | — | 1 (best 0.31) |
| 4JL7 | Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1 | x-ray diffraction | A | CL | 1 (best 0.29) |
| 4JL7 | Crystal structure of the chemokine receptor CXCR2 in complex with the first PDZ domain of NHERF1 | x-ray diffraction | A | CL | 1 (best 0.29) |
| 4LMM | Crystal structure of NHERF1 PDZ1 domain complexed with the CXCR2 C-terminal tail in P21 space group | x-ray diffraction | A | CL | 1 (best 0.33) |
| 4LMM | Crystal structure of NHERF1 PDZ1 domain complexed with the CXCR2 C- terminal tail in P21 space group | x-ray diffraction | A | CL | 1 (best 0.33) |
| 4MPA | Crystal structure of NHERF1-CXCR2 signaling complex in P21 space group | x-ray diffraction | A | CL | 1 (best 0.34) |
| 4MPA | Crystal structure of NHERF1-CXCR2 signaling complex in P21 space group | x-ray diffraction | A | CL | 1 (best 0.34) |
| 4N6X | Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1 | x-ray diffraction | A | CL | 1 (best 0.29) |
| 4N6X | Crystal structure of the chemokine receptor CXCR2 in complex with the first PDZ domain of NHERF1 | x-ray diffraction | A | CL | 1 (best 0.29) |
| 4PQW | Crystal Structure of Phospholipase C beta 3 in Complex with PDZ1 of NHERF1 | x-ray diffraction | A | CL, NI | 1 (best 0.32) |
| 4PQW | Crystal structure of phospholipase C beta 3 in complex with PDZ1 of NHERF1 | x-ray diffraction | A | CL, NI | 1 (best 0.32) |
| 4Q3H | The crystal structure of NHERF1 PDZ2 CXCR2 complex revealed by the NHERF1 CXCR2 chimeric protein | x-ray diffraction | A, B | — | 2 (best 0.32) |
| 4Q3H | The crystal structure of NHERF1 PDZ2 CXCR2 complex revealed by the NHERF1 CXCR2 chimeric protein | x-ray diffraction | A, B | — | 2 (best 0.32) |
| 6RQR | Extended NHERF1 PDZ2 domain in complex with the PDZ-binding motif of CFTR | x-ray diffraction | A, B | — | 2 (best 0.34) |
| 6RQR | Extended NHERF1 PDZ2 domain in complex with the PDZ-binding motif of cftr | x-ray diffraction | A, B | — | 2 (best 0.34) |
| O14745 | AlphaFold monomer V2.0 prediction for NA(+)/H(+) exchange regulatory cofactor nhe-RF1 (O14745) | predicted | A | — | 2 (best 0.29) |
Ligands
Experiment against prediction
- 1GQ5 chain A against the predicted model O14745: TM-score 0.93, RMSD 1.24 Å
- 1GQ5 chain A against the predicted model O14745: TM-score 0.93, RMSD 1.24 Å
- 1I92 chain A against the predicted model O14745: TM-score 0.93, RMSD 1.22 Å
- 1I92 chain A against the predicted model O14745: TM-score 0.93, RMSD 1.22 Å
- 4PQW chain A against the predicted model O14745: TM-score 0.92, RMSD 1.23 Å
- 4PQW chain A against the predicted model O14745: TM-score 0.92, RMSD 1.23 Å
- 4JL7 chain A against the predicted model O14745: TM-score 0.92, RMSD 1.24 Å
- 4JL7 chain A against the predicted model O14745: TM-score 0.92, RMSD 1.24 Å
- 2OZF chain A against the predicted model O14745: TM-score 0.92, RMSD 1.23 Å
- 2OZF chain A against the predicted model O14745: TM-score 0.92, RMSD 1.23 Å
Elsewhere
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