MolNFT v1 · #100160 · protein
Crystal structure of NHERF1-CXCR2 signaling complex in P21 space group
4MPA · NA(+)/H(+) exchange regulatory cofactor nhe-RF1, C-X-C…: “Crystal structure of NHERF1-CXCR2 signaling complex in P21 space group”. X-ray diffraction, 1 ligand (CL), 1 pocket (best druggability 0.34). MolNFT v1 #100160 on GenesisL1…
- PDB
- 4MPA
- Type
- protein
- Length
- 91 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NA(+)/H(+) exchange regulatory cofactor nhe-RF1, C-X-C chemokine receptor type 2 chimera
- UniProt
- O14745, P25025
- Ligands
- CL
- Pockets
- 1 · best druggability 0.34
Structure
x-ray diffraction · 1 distinct chain · 15% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NA(+)/H(+) exchange regulatory cofactor nhe-RF1, C-X-C chemokine receptor type 2 chimera | protein | 91 | 15% helix, 31% strand | O14745, P25025 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 70 | 0.34 | 0.76 | 13 | empty |
Compared structures
- 4MPA · Crystal structure of NHERF1-CXCR2 signaling complex in P21 space group · the same entry in another collection · chain A against A, TM-score 1.00
- O14745 · AlphaFold monomer V2.0 prediction for NA(+)/H(+) exchange regulatory cofactor nhe-RF1… · a predicted model of the same protein · chain A against A, TM-score 0.89
- P25025 · AlphaFold monomer V2.0 prediction for C-X-C chemokine receptor type 2 (P25025) · a predicted model of the same protein · chain A against A, TM-score 0.34
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14745
- Every structure of UniProt P25025
- Elsewhere: RCSB PDB 4MPA · PDBe 4MPA · UniProt O14745 · UniProt P25025
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